Investigation of time course of changes in the concentrations of angiogenic factors on the length of physiological pregnancy


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Objective. To determine the serum concentrations of vascular endothelial growth factor (VEGF), placental growth factor (PlGF), and soluble VEGF receptor 1 (sVEGF-R1) in pregnant women with physiological pregnancy. Subjects and methods. A prospective cohort study was conducted in 114 women with physiological pregnancy. The factors were controlled at 11-13, 22-24, and 32-34 weeks’ gestation. The levels of VEGF was determined by an enzyme immunoassay and those of sVEGF-R1 by an electrochemiluminiscence immunoassay. Results. There was a rise in the concentration of PlGF with longer gestation. The level of PlGF was 51.9±7.2 and 481.3±27.3 pg/ml at 11-13 and 32-34 weeks’ gestation, respectively. That of VEGF increased from the first to the second trimester of pregnancy and decreased by 32-34 weeks’ gestation. The concentration of sVEGF-R1 remained relatively stable in the first and the second trimester of pregnancy (1991.6±30.7and 1980.7±27.7 pg/ml, respectively). At 32-34 weeks’ gestation, there was an increase in the indicator up to 2266.5±51.3pg/ml. Conclusion. The findings demonstrate the process of physiological angiogenesis and the investigation used in our descriptive study should be regarded as a diagnostic procedure in the examination of women at risk for vascular events.

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作者简介

N. Yakovleva

V.A. Almazov North-West Federal Medical Research Center, Ministry of Health of Russia

Email: Natalis.1986@mail.ru
MD, researcher of scientific research laboratory of physiology and pathology of pregnancy and delivery

E. Vasilyeva

V.A. Almazov North-West Federal Medical Research Center, Ministry of Health of Russia

Email: elena-almazlab@yandex.ru
MD, head of central diagnostic laboratory

E. Shelepova

V.A. Almazov North-West Federal Medical Research Center, Ministry of Health of Russia

Email: garbunchik@mail.ru
MD, researcher of scientific research laboratory of reproduction and women health

N. Ryabokon

V.A. Almazov North-West Federal Medical Research Center, Ministry of Health of Russia

Email: n-i-k-o-n@mail.ru
MD, Teaching Assistant, chair of Obstetrics and Gynecology

E. Khazova

V.A. Almazov North-West Federal Medical Research Center, Ministry of Health of Russia

Email: kamishi77@mail.ru
MD, researcher of scientific research laboratory of reproduction and women health

K. Buravleva

Obstetrics and Gynecology

Email: k_senia9l@mail.ru
resident of chair

L. Kuznetsova

V.A. Almazov North-West Federal Medical Research Center

Email: krivo73@mail.ru
MD, PhD, assistant professor of chair of Obstetrics and Gynecology

I. Zazerskaya

V.A. Almazov North-West Federal Medical Research Center

Email: zazera@mail.ru
MD, PhD, head of chair of Obstetrics and Gynecology

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