Pregnancy and childbirth in a patient with myelodysplastic syndrome


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Background. As of now, progress in therapy has frequently made it possible to plan pregnancy and safe childbirth in women with different hematological diseases. Myelodysplastic syndrome (MDS) is a group of severe clonal hematopoietic diseases that are most common in the old age group. Pregnancy in patients with MDS is extremely rare and associated with an increased risk of both maternal and fetal complications. Case report. The paper describes a case of successful pregnancy and childbirth in a 30-year-old patient with partial remission of refractory anemia with excess of blasts. Conclusion. Adequate initial therapy for the underlying disease, planning, and careful interdisciplinary follow-up throughout the gestation has promoted a favorable pregnancy outcome.

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作者简介

Roman Shmakov

Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: r_shmakov@oparina4.ru
M.D., Head Physician

Maria Vinogradova

Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: m_vinogradova@oparina4.ru
Ph.D, Head of reproductive hematology and hemostasia department

Evgenia Polushkina

Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: epolushkina@mail.ru
Ph.D, Researcher, Obstetrical Physiologic Department

Elena Kozyrko

Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: lenochka525@gmail.com
Researcher, Obstetrical Physiologic Department

参考

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  2. Кохно А.В., Паровичникова Е.Н., Савченко В.Г. Миелодиспластический синдром. Клиническая геронтология. 2009; 15(3): 33-46. [Kohno A.V., Parovichnikova E.N., Savchenko V.G. Myelodysplastic syndrome. Klinicheskaya gerontologiya. 2009; 15 (3): 33-46. (in Russian)]
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  4. Al-Ameri A., Cherry M., Garcia-Manero G., Quintás-Cardama A. Standard therapy for patients with myelodysplastic syndromes. Clin. Lymphoma Myeloma Leuk. 2011; 11(4): 303-13. doi: 10.1016/j.clml.2011.06.008.
  5. NCCN Clinical Practice Guidelines in Oncology. Myelodysplastic syndromes v 1.2012. Available at: http://www.nccn.org/professionals/ physician_gls/pdf/ mds.pdf Accessed March 9, 2012.
  6. Yang Z., Mei-Ying L., Shan-Mi W., Xiao-Hui Z. Pregnancy and myelodys-plastic syndrome: an analysis of the clinical characteristics, maternal and fetal outcomes. J. Matern. Fetal Neonatal Med. 2015; 28(18): 2155-9. doi: 10.3109/14767058.2014.980229.

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