QUANTIFICATION OF PLASMA MICRORNA EXPRESSION IN PREGNANT WOMEN WITH PREECLAMPSIA


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Objective. To study the expression of plasma microRNAs (has-mir-29b-3P, has-mir-34a-5p, has-mir-141-3p, and miR-376c) in preeclampsia (PE). Material and methods. 36 pregnant women were examined, by analyzing their clinical characteristics and investigating the expression of plasma microRNA. Results. There was a significant increase in the expression of three microRNAs: has-mir-29b-3p, has-mir-34a-5p, and has-mir-141-3p in the plasma of pregnant women with PE as compared to the control group. There were differences in the expression of miR-376c, but there was a high degree of variation in the expression level in the groups. The highest diagnostic accuracy ( 76.7%) was achieved with the simultaneous assessment of the expression level of the three m icroRNAs. Conclusion. The changes in the expression level of the investigated microRNAs are closely correlated with the development of PE. The quantification of plasma microRNA expression in the period after 30 weeks allows for the identification of pregnant women with PE with high accuracy.

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作者简介

Ksenia Prozorovskaya

Email: ksenyap@inbox.ru
obstetrician-gynecologist in obstetrical observational department, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

Leonid Fayzullin

Email: l_faizullin@oparina4.ru
M.D., senior scientific researcher in the laboratory of molecular and genetic methods, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia 117997, Russia, Moscow, Ac. Oparina str. 4

Vitaliy Karnauhov

Email: v_karnauhov@oparina4.ru
junior scientific researcher in the laboratory of molecular and genetic methods, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia 117997, Russia, Moscow, Ac. Oparina str. 4

Natalia Kan

Email: kan-med@mail.ru
M.D., PhD; the head of the obstetrical observational department, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia 117997, Russia, Moscow, Ac. Oparina str. 4

Victor Tyutyunnik

Email: tioutiounnik@mail.ru
M.D., PhD; the head of the obstetric physiological department, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia 117997, Russia, Moscow, Ac. Oparina str. 4

Maria Ganichkina

Email: mariaganichkina@yandex.ru
junior scientific researcher, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

Olga Sergunina

Email: o_sergunina@oparina4.ru
obstetrician-gynecologist in obstetrical observational department, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

Andrey Chausov

Email: a_chausov@oparina4.ru
junior scientific researcher in the department of medical and social researches, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

Nataliya Tyutyunnik

Email: tysia07@bk.ru
the resident, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

Diana Mantrova

Email: d-mantrova@yandex.ru
junior scientific researcher, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

Dmitry Trofimov

Email: d_trofimov@oparina4.ru
M.D., PhD, the Head of the laboratory of molecular and genetic methods, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

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