STUDY OF THE BIOCOMPATIBILITY OF RESORBABLE MESH PROSTHESES FOR PLASTIC SURGERY REPAIR OF ABDOMINAL WALL AND SMALL PELVIC FLOOR DEFECTS


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Subject. Comparison of physico-chemical and biomedical properties of test specimens of mesh implants based on polydioxanone and polyglycolide, looking for application in gynecology and general surgery. Material and methods. In vitro evaluation of cytotoxicity of samples was performed using the MTT assay. Assessment of in vivo biocompatibility prosthesis was performed on outbred rats by simulating polnosloynogo defect of the anterior abdominal wall, which is sutured to the edges of polydioxanone and polyglycolic prosthesis. As a comparison group using the prosthesis on the basis of detsellyulyarizirovannoy dermis (Permacol). The animals were taken from the experiment 3, 10, 30 and 60 days after surgery. Was conducted macroscopic, tenziometricheskoe, morphometric, immunohistochemical and western blot studies. Results. The test prostheses do not possess cytotoxic properties, but in an in vivo experiment showed different intensity of adhesions, the speed and efficiency of integration with the surrounding tissues, preservation of the biomechanical properties of the severity of the inflammatory response. Conclusion. For some indicators of biocompatibility and efficacy of polydioxanone prosthesis was significantly better than prosthesis from polyglycolide and detsellyulyarizirovannoy dermis

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作者简介

Olesya Vasyukova

Email: olesya.vasyukova.rnrmu@gmail.com
Executive Manager on the Agreement with the Ministry of Education of the Russian Federation of 22.08.2014 14.613.21.0008, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia; junior researcher, Laboratory of growth and development, Research Institute of Human Morphology 117418, Russia, Moscow, Tsurupy str. 3

Irina Arutyunyan

Email: labrosta@yandex.ru
researcher of the Laboratory for Regenerative Medicine, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia; researcher, Laboratory of growth and development, Research Institute of Human Morphology. 117997, Russia, Moscow, Ac. Oparina str. 4

Larisa Tsedik

Email: tslara@rambler.ru
researcher of the laboratory of composite and powder materials, Institute for Powder Metallurgy. 220071, Belarus, Minsk, Platonova str. 41

Alexey Korshunov

Email: a_korshunov@oparina4.ru
an obstetrician-gynecologist of the department of combined and complex treatment of gynecological diseases, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

Andrey Elchaninov

Email: elchandrey@yandex.ru
PhD, Senior Scientist, Laboratory for Regenerative Medicine, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia; senior researcher, Laboratory of growth and development, Research Institute of Human Morphology. 117997, Russia, Moscow, Ac. Oparina str. 4

Eugene Kananykhin

Email: e.kananykhina@gmail.com
junior researcher, Laboratory for Regenerative Medicine, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia; graduated student, Laboratory of growth and development, Research Institute of Human Morphology. 117997, Russia, Moscow, Ac. Oparina str. 4

Anastasia Lokhonina

Email: nastya.serbsky@gmail.com
junior researcher, Laboratory for Regenerative Medicine, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

Andrey Makarov

Email: anvitmak@yandex.ru
MD, PhD, Senior Scientist Laboratory for Regenerative Medicine, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia; leading researcher, Research Institute of Human Morphology. 117997, Russia, Moscow, Ac. Oparina str. 4

Elena Uvarova

Email: elena-uvarova@yandex.ru
MD, Professor, Head of the 2nd gynecological department (children and youth gynecology), Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia; the President of the Inter-regional Public Organization „Association of Pediatric and Adolescent Gynecology.” 117997, Russia, Moscow, Ac. Oparina str. 4

Vladimir Chuprynin

Email: v_chuprinin@oparina4.ru
MD, PhD, Head of the surgical department, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

Irina Eremina

Email: eremina@med.rudn.ru
Ph.D., Acting Head of the Department of Histology, Cytology and Embryology, Associate Professor of Histology, Cytology and Embryology, Peoples' Friendship University. Russia, Moscow, Miklulkho-Maklaya str. 8

Timur Fathudinov

Email: tfat@yandex.ru
MD, Head of the Laboratory of Regenerative Medicine, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia; Professor, Department of Histology, Cytology and Embryology, Peoples' Friendship University. 117997, Russia, Moscow, Ac. Oparina str. 4

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