The evidence base of the efficiency of treatment for menopausal syndrome with intravaginal hormonal agents


如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

Objective. To carry out a systematic analysis of the data available in modern Russian and foreign literature on the efficiency of treatment for menopausal syndrome with intravaginal hormonal agents, such as Ovipol Clio. Material and methods. The review includes the data of foreign and Russian articles published in the past 10 years and found in the Pubmed on this topic. Particular attention is given to the 2015-2017articles. Results. The paper describes the evidence base of the efficiency and safety of estriol-containing intravaginal drugs, such as Ovipol Clio, in the treatment of menopausal syndrome. Analyzing the literature has clearly shown that the use of Ovipol Clio causes a significant reduction in menopausal symptoms and an improvement of a woman’s urogenital health. In this case, the earlier the treatment is initiated after the onset of menopause, the lower risk of menopause-associated pathological conditions. Conclusion. Additional studies on the safety and efficiency of transvaginal estriol deserve further examination.

全文:

受限制的访问

作者简介

Raisa Chilova

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia; V.F. Snegirev Clinic of Obstetrics and Gynecology

MD, Professor of the Department of Obstetrics and Gynecology No. 1

Yuri Chushkov

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia

Email: yury-chushkov@rambler.ru
MD, associate professor of the Department of Obstetrics and Gynecology No. 1

Guzel Proklova

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia; V.F. Snegirev Clinic of Obstetrics and Gynecology

aboratory assistant of the Department of Obstetrics and Gynecology No. 1

参考

  1. Балан В.Е. Вагинальная атрофия в климактерии: лекция. Эффективная фармакотерапия в акушерстве и гинекологии. 2009; 3: 40-3. [Balan V.E. Vaginal atrophy in menopause: lecture. Effective pharmacotherapy in obstetrics and gynecology. 2009; 3: 40-3. (in Russian)]
  2. Занько С.Н., Радецкая Л.Е. Заместительная гормональная терапия: дифференцированный подход. Методическое пособие. Минск: Доктор Дизайн; 2008: 25. [Zanko S.N., Radetska L.E. Hormone replacement therapy: a differentiated approach. Toolkit. Minsk: Doctor Design; 2008: 25. (in Russian)]
  3. Сметник В.П. Медико-социальные проблемы климактерия. В кн.: Кулаков В.И., Демидова Е.М., ред. Гормональная коррекция системных изменений в менопаузе. Материалы симпозиума. М.; 1997: 7-14. [Smetnik VP Medico-social problems of menopause. In: Kulakov VI., Demidova E.M., ed. Hormonal correction of systemic changes in menopause. Materials of the symposium. Moscow; 1997: 7-14. (in Russian)]
  4. Шаповаленко С.А. Комплексная терапия психосоматических расстройств в перименопаузальный период. Вестник Российской ассоциации акушеров и гинекологов. 2000; 1: 91-5. [Shapovalenko S.A. Complex therapy of psychosomatic disorders in the perimenopausal period. Bulletin of the Russian Association of Obstetricians and Gynecologists. 2000; 1: 91-5. (in Russian)]
  5. Репина М.А. Выпадение функции яичников и заместительное гормональное лечение. Журнал акушерства и женских болезней. 1999; 67(1): 72-6. [Repina M.A. Abnormal ovarian function and hormone replacement therapy. Zhurnal akusherstva i zhenskih bolezney. 1999; 67 (1): 72-6. (in Russian)]
  6. Crandall C.J., Hovey K.M., Andrews C.A., Chlebowski R.T., Stefanick M.L., Lane D.S. et al. Breast cancer, endometrial cancer, and cardiovascular events in participants who used vaginal estrogen in the Women’s Health Initiative Observational Study. Menopause. 2017; August 14. doi: 10.1097/ GME.0000000000000956.
  7. Ali E.S., Mangold C., Peiris A.N. Estriol: emerging clinical benefits Menopause. 2017; 24(9): 1081-5. doi: 10.1097/GME.0000000000000855.
  8. The NAMS 2017 Hormone Therapy Position Statement Advisory Panel. The 2017 hormone therapy position statement of The North American Menopause Society. Menopause. 2017; 24(7): 728-53. doi: 10.1097/GME.0000000000000921.
  9. Cruz V.L., Steiner M.L., Pompei L.M., Strufaldi R., Fonseca F.L.A., Santiago L.H.S. et al. Randomized, double-blind, placebo-controlled clinical trial for evaluating the efficacy of fractional CO2 laser compared with topical estriol in the treatment of vaginal atrophy in postmenopausal women. Menopause. 2017; July 31. doi: 10.1097/GME.0000000000000955.
  10. Hodis H.N., Mack W.J., Shoupe D., Azen S.P., Stanczyk F.Z., Hwang-Levine J. et al. Methods and baseline cardiovascular data from the Early versus Late Intervention Trial with Estradiol testing the menopausal hormone timing hypothesis. Menopause. 2015; 22(4): 391-401. doi: 10.1097/GME.0000000000000343.

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © Bionika Media, 2017
##common.cookie##