Maternal smoking and DNA methylation abnormalities in children at early developmental stages
- 作者: Odintsova V.V.1,2,3,4, Saifitdinova A.F.3,5, Naumova O.Y.6,7
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隶属关系:
- National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov
- VU University
- Saint Petersburg State University
- Central Research Institute for Public Health Organization and Informatization, Ministry of Health of Russia
- International Center for Reproductive Medicine
- N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences
- University of Houston
- 期: 编号 9 (2018)
- 页面: 5-12
- 栏目: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/248265
- DOI: https://doi.org/10.18565/aig.2018.9.5-12
- ID: 248265
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详细
The paper analyzes the results of current studies of the role of DNA methylation during human embryonic development and the effects of tobacco smoke from maternal smoking on the epigenetic status of a developing child. The molecular mechanisms mediating the association between maternal smoking and its effects on the development and health of the offspring, especially its long-term effects that manifest throughout his/her life are the object of active research in medicine and biology. Human genomics studies in recent years have shown that one of these mechanisms may be the epigenetic regulation of gene activity, namely, stable tobacco smoke-induced alterations in this system can cause concomitant smoking-related developmental and health problems. Active smoking is an important risk factor for morbidity and premature mortality, while maternal smoking during pregnancy has a double effect: firstly, it adversely affects women’s health and secondly, it leads to irreparable fetal developmental disorders and affects the health and development of the newborn and the quality of his/her subsequent life.
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作者简介
Veronika Odintsova
National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov; VU University; Saint Petersburg State University; Central Research Institute for Public Health Organization and Informatization, Ministry of Health of Russia
Email: veronika.od@gmail.com
PhD in Medicine, PhD researcher, Department of Biological Psychology; advisor
Alsu Saifitdinova
Saint Petersburg State University; International Center for Reproductive Medicine
Email: saifitdinova@mail.ru
Director of the Research Recourse Center “Chromas Core Facility”; Deputy Head of the Laboratory of Assisted Reproductive Technologies
Oxana Naumova
N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences; University of Houston
Email: oksana.yu.naumova@gmail.com
PhD, Senior Researcher
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补充文件
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