Clinical and morphometric characteristics of endometrial polyps and underlying mechanisms of abnormal uterine bleeding


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The incidence of various types of abnormal uterine bleeding (AUB) in patients with endometrial polyps (EP) and their underlying mechanisms remain unclear, which causes diff iculties in the diagnosis and the choice of optimal management strategy. Aim To investigate the histological and morphometric characteristics of EPs and their association with AUB. Materials and methods. Medical records (n = 130) were reviewed to retrospectively analyze the course of the disease, histological, and morphometric characteristics of EPs. Results. In the study cohort, 60.8% of patients with EPs had AUB, every second woman had AUB characterized by prolonged and excessive menstrual bleeding, every third had intermenstrual bleeding, and the remaining patients had their combination. Morphometric analysis showed that EPs associated AUB had dilated thin-walled capillaries. Co-occurrence of EPs with chronic endometritis (CE) aggravates the vascular changes and increases the likelihood of AUB. Conclusions. AUB that was observed in every second patient with EP may be caused by the vascular wall pathological abnormalities, which were most significantly expressed in patients with CE.

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作者简介

Alexandra Asaturova

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology of Minzdrav of Russia

Email: a_asaturova@oparina4.ru
Ph.D., Senior Researcher at the Department of Anatomic Pathology

Galina Chernukha

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology of Minzdrav of Russia

Email: g_chernukha@oparina4.ru
Professor, Dr.Med.Sci., Head of the Department of Gynecologic Endocrinology

Ilya Ivanov

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology of Minzdrav of Russia

Email: doctor.i.ivanov@yandex.ru
Ph.D. Student at the Department of Gynecologic Endocrinology

Andrey Kuzemin

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology of Minzdrav of Russia

Email: andkuzemin@mail.ru
Ph.D., Head the One Day Clinic.

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