The influence of immunosuppressive therapy during pregnancy on the immune system of the mother and the newborn


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Aim. The comparative analysis of study results ofnewborn immune system in women who received immunosuppressive chemotherapy during pregnancy. Material and methods. Physical examination of pregnant women with transplanted organs, oncological or autoimmune diseases and their newborns (n=106) was carried out. The method of flow cytometry was used for phenotyping lymphocytes in the umbilical cord blood of newborns (n=82), as well as in the venous blood of their mothers. The serum immunoglobulin’s concentration had determined of turbidimetric method. Results. We revealed the decreasing in the ratio CD3+CD4+/CD3+CD8+ and the percentage of B-lymphocytes, and the increasing of the percentage of activated T-lymphocytes in pregnant women with various pathologies who received immunosuppressive therapy. The percentage of B-lymphocytes in the umbilical cord blood of newborns was reduced. The differences in the percentage of T-lymphocytes were absent. Conclusion. The state of health in children who had born in women with immunosuppressive therapy was a satisfactory state in the early neonatal period and the changes in immune indicators were significantly less, compared with those in mothers.

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作者简介

L. Vanko

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation

Email: lvanko@mail.ru

V. Zubkov

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation

Email: v_zubkov@oparina4.ru

L. Krechetova

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation

Email: l_krechetova@oparina4.ru

M. Makieva

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation

Email: m_makieva@oparina4.ru

E. Baybarina

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation

Email: BaybarinaEN@rosminzdrav.ru

E. Shatalova

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation

Email: e_shatalova@oparina4.ru

A. Zhukova

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation

Email: a_belyaeva@oparina4.ru

N. Klimenchenko

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation

Email: natalite@list.ru

R. Shmakov

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation

Email: r_shmakov@oparina4.ru

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