CHANGES IN THE SERUM CONCENTRATIONS OF CCL CHEMOKINES (MCP-1, MIP-1a, MIP-1P, RANTES, AND EOTAXIN) IN WOMEN WITH UTERINE MYOMA


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Objective. To investigate the serum concentrations of the chemokines MCP-1, MIP-1a, MIP-1P, RANTES and Eotaxin in women with uterine myoma (UM). Subjects and methods. Thirty-six Caucasian patients with UM who had undergone surgical treatment as laparoscopic myomectomy were followed up. Serum chemokine concentrations were simultaneously analyzed using the standardized Bio-Plex9 multiplex immunoassay methods based on xMAP technology. Results. In the patients with UM, the increase in the serum concentration of RANTES (p < 0.01) was shown to be accompanied with the decrease in that of chemokines, such as Eotaxin, MIP-1a, and MIP-1P (p < 0.001, р < 0.05, and р < 0.001, respectively). At the same time, the reduced concentrations of the chemokines CCL2 (MCPT1), CCL3 (MIP-1a), CCL4 (MIP-1P), and CCL11 (Eotaxin) directly correlated with each other. Conclusion. An analysis of the findings may lead to the conclusion that there is chemokine network dysfunction in UM, which is manifested by differently directional and correlated changes in the serum concentration of CC chemokines in UM.

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作者简介

Vladimir Konenkov

Research Institute of Clinical and Experimental Lymphology, Branch, Federal Research Center, Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences

Email: vikonenkov@gmail.com
Ph.D., Professor, Academician of Russian Sciences Academy, Honored Worker of Science of the Russian Federation, Scientific Director, Head of clinical immunogenetics laboratory 630060 Russia, Novosibirsk, Timakova Street, 2

Elena Koroleva

Research Institute of Clinical and Experimental Lymphology, Branch, Federal Research Center, Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences

Email: lymphology@niikel.ru
MD, Researcher of Cell Technologies Laboratory 630060 Russia, Novosibirsk, Timakova Street, 2

Nikolay Orlov

Research Institute of Clinical and Experimental Lymphology, Branch, Federal Research Center, Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences

Email: nbo700@mail.ru
Ph.D., major researcher 630060 Russia, Novosibirsk, Timakova Street, 2

Viktor Prokofev

Research Institute of Clinical and Experimental Lymphology, Branch, Federal Research Center, Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences

Email: vf_prok@mail.ru
PhD, Leading Researcher of Clinical Immunogenetics Laboratory 630060 Russia, Novosibirsk, Timakova Street, 2

Alla Shevchenko

Research Institute of Clinical and Experimental Lymphology, Branch, Federal Research Center, Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences

Email: shalla64@mail.ru
Ph.D., Leading Researcher, Clinical Immunogenetics Laboratory 630060 Russia, Novosibirsk, Timakova Street, 2

Alexey Novikov

Research Institute of Clinical and Experimental Lymphology, Branch, Federal Research Center, Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences

Email: novis.ngmu@gmail.com
MD, Junior Researcher, Laboratory of Cell Technologies 630060 Russia, Novosibirsk, Timakova Street, 2

Tatyana Dergacheva

Research Institute of Clinical and Experimental Lymphology, Branch, Federal Research Center, Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences

Email: dr-tanja@yandex.ru
PhD, professor, leading researcher of functional morphology of lymphatic system laboratory 630060 Russia, Novosibirsk, Timakova Street, 2

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