THE EFFECTIVENESS OF TARGETED INTERFERON REPLACEMENT THERAPY IN PATIENTS WITH EXTRAGENITAL ENDOMETRIOSIS
- 作者: YARMOLINSKAYA M.I.1,2, DURNEVA E.I.1, SEL'KOV S.A.1, CHEPANOV S.V.1, SELYUTIN A.V.1, SOKOLOV D.I.1
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隶属关系:
- D.O. Ott Research Institute for Obstetrics and Gynecology of the RAS
- I.I. Mechnikov North-Western State Medical University of Minzdrav of Russia
- 期: 编号 5 (2020)
- 页面: 105-112
- 栏目: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/248892
- DOI: https://doi.org/10.18565/aig.2020.5.105-12
- ID: 248892
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作者简介
Mariya YARMOLINSKAYA
D.O. Ott Research Institute for Obstetrics and Gynecology of the RAS; I.I. Mechnikov North-Western State Medical University of Minzdrav of Russia
Email: m.yarmolinskaya@gmail.com
Dr.Med.Sci., Professor of the RAS, Head of the Department of Gynecology and Endocrinology, Head of the Center of Diagnosis and Treatment of Endometriosis, D.O. Ott Research Institute for Obstetrics and Gynecology, Professor at the Department of Obstetrics and Gynecology, I.I. Mechnikov North-Western State Medical University St. Petersburg, Russia
Elena DURNEVA
D.O. Ott Research Institute for Obstetrics and Gynecology of the RAS
Email: elenadurnevai303@gmail.com
Ph.D. Student at the Department of Gynecology and Endocrinology St. Petersburg, Russia
Sergey SEL'KOV
D.O. Ott Research Institute for Obstetrics and Gynecology of the RAS
Email: selkovsa@mail.ru
Merited Scholar of the Russian Federation, Professor, Head of the Department of Immunology and Intercellular Interactions St. Petersburg, Russia
Sergey CHEPANOV
D.O. Ott Research Institute for Obstetrics and Gynecology of the RAS
Email: chepanovsv@gmail.com
Ph.D., Senior Researcher at the Proteomic Immunoregulation Group, Department of Immunology and Intercellular Interactions St. Petersburg, Russia
Alexander SELYUTIN
D.O. Ott Research Institute for Obstetrics and Gynecology of the RAS
Email: a_selutin@yahoo.com
Ph.D. (biol.sci.), Senior Researcher at the Immunology Laboratory with AIDS Diagnostics Group, Department of Immunology and Intercellular Interactions St. Petersburg, Russia
Dmitriy SOKOLOV
D.O. Ott Research Institute for Obstetrics and Gynecology of the RAS
Email: falcojugger@yandex.ru
Dr.Biol.Sci., Head of the Laboratory of Intercellular Interactions, Department of Immunology and Intercellular Interactions St. Petersburg, Russia
参考
- Bulun S.E., Yilmaz B.D., Sison C., Miyazaki K., Bernardi L., Liu S. et al. Endometriosis. Endocr. Rev. 2019; 40(4): 1048-9. https://dx.doi.org/10.1210/ er.2018-00242.
- Culley L., Law C., Hudson N., Denny E., Mitchell H., Baumgarten M. et al. The social and psychological impact of endometriosis on women’s lives: a critical narrative review. Hum. Reprod. Update. 2013; 19(6): 625-39. https://dx.doi. org/10.1093/humupd/dmt027.
- Symons L.K., Miller J.E., Kay V.R., Marks R.M., Liblik K., Koti M. et al. The immunopathophysiology of endometriosis. Trends Mol. Med. 2018; 24(9): 748-62. https://dx.doi.org/10.1016/j.molmed. 2018.07.004.
- Osuga Y., Koga K., Hirota Y., Hirata T., Yoshino O., Taketani Y. Lymphocytes in endometriosis. Am. J. Reprod. Immunol. 2011; 65(1): 1-10. https://dx.doi. org/10.1111/j.1600-0897.2010.00887.x.
- Sourial S., Tempest N., Hapangama D.K. Theories on the pathogenesis of endometriosis. Int. J. Reprod. Med. 2014; 2014: 179515. https://dx.doi. org/10.1155/2014/179515.
- Dicitore A., Castiglioni S., Saronni D., Gentilini D., Borghi M.O., Stabile S. et al. Effects of human recombinant type I IFNs (IFN-alpha2b and IFN-beta1a) on growth and migration of primary endometrial stromal cells from women with deeply infiltrating endometriosis: A preliminary study. Eur. J. Obstet. Gynecol. Reprod. Biol. 2018; 230: 192-8. https://dx.doi.org/10.1016/j. ejogrb.2018.10.004.
- Gonzalez-Navajas J.M., Lee J., David M., Raz E. Immunomodulatory functions of type I interferons. Nat. Rev. Immunol. 2012; 12(2): 125-35. https://dx.doi. org/10.1038/nri3133.
- Ingelmo J.M., Quereda F., Acien P. Effect of human interferon-alpha-2b on experimental endometriosis in rats: comparison between short and long series of treatment. Eur. J. Obstet. Gynecol. Reprod. Biol. 2013; 167(2): 190-3. https:// dx.doi.org/10.1016/j.ejogrb.2012.11.019.
- Badawy S.Z., Etman A., Cuenca V., Montante A., Kaufman L. Effect of interferon alpha-2b on endometrioma cells in vitro. Obstet. Gynecol. 2001; 98(3): 417-20. https://dx.doi.org/10.1016/S0029-7844(01)01395-3.
- Ingelmo J.M., Quereda F., Acien P. Intraperitoneal and subcutaneous treatment of experimental endometriosis with recombinant human interferon-alpha-2b in a murine model. Fertil. Steril. 1999; 71(5): 907-11. https://dx.doi.org/10.1016/ S0015-0282(99)00087-4.
- Павлов Р.В., Сельков С.А. Эффективность внутрибрюшинного применения интерферона в терапии экспериментального эндометриоза у крыс. Медицинская иммунология. 2006; 8(5-8): 721-6.
- Ali A.F.M., Fateen B., Ezzet A., Badawy H., Ramadan A., El-tobge A. Laparoscopic intraperitoneal injection of human interferon-a2b in the treatment of pelvic endometriosis: a new modality. Obstet. Gynecol. 2000; 95(4, Suppl. 1): 547--8. https://dx.doi.org/10.1016/S0029-7844(00)00684-0.
- Acien P., Quereda F., Campos A., Gomez-Torres M.J., Velasco I., Gutierrez M. Use of intraperitoneal interferon alpha-2b therapy after conservative surgery for endometriosis and postoperative medical treatment with depot gonadotropin-releasing hormone analog: a randomized clinical trial. Fertil. Steril. 2002; 78(4): 705-11. https://dx.doi.org/10.1016/S0015-0282(02) 03330-7.
- Дурнева Е.И., Ярмолинская М.И., Соколов Д.И., Сельков С.А., Селютин А.В. Клиническая эффективность и патогенетическое обоснование применения человеческого рекомбинантного интерферона альфа-2 b в комбинированном лечении больных наружным генитальным эндометриозом. Вопросы гинекологии, акушерства и перинатологии. 2019; 18(2): 61-8. https://dx.doi.org/10.20953/1726-1678-2019-2-61-68.
- Alter G., Malenfant J.M., Altfeld M. CD107a as a functional marker for the identification of natural killer cell activity. J. Immunol. Methods. 2004; 294(1-2): 15-22. https://dx.doi.org/10.1016/j.jim.2004. 08.008.
- Dunselman G.A., Vermeulen N., Becker C., Calhaz-Jorge C., D’Hooghe T., De Bie B. et al. ESHRE guideline: management of women with endometriosis. Hum. Reprod. 2014; 29(3): 400-12. https//dx.doi.org/10.1093/humrep/det457.
- Bishop L.A. Management of chronic pelvic pain. Clin. Obstet. Gynecol. 2017; 60(3): 524-30. https://dx.doi.org/10.1097/GRF.0000000000000299.
- Акинфиева О.В., Бубнова Л.Н. NKT-клетки: характерные свойства и функциональная значимость для регуляции иммунного ответа. Онкогематология. 2010; 4: 39-47.
- Negishi Y., Takahashi H., Kuwabara Y., Takeshita T. Innate immune cells in reproduction. J. Obstet. Gynaecol. Res. 2018; 44(11): 2025-36. https://dx.doi. org/10.1111/jog.13759.
- Spaccarelli N., Rook A. The use of interferons in the treatment of cutaneous T-cell lymphoma. Dermatol. Clin. 2015; 33(4): 731-45. https://dx.doi. org/10.1016/j.det.2015.05.008.
- Lapenta C., Donati S., Spadaro F., Castaldo P., Belardelli F., Cox M.C., Santini S.M. NK cell activation in the antitumor response induced by IFN-alpha dendritic cells loaded with apoptotic cells from follicular lymphoma patients. J. Immunol. 2016; 197(3): 795-806. https://dx.doi.org/10.4049/ jimmunol.1600262.
- Бекетова Г.В. Интерфероны в лечении острых респираторных инфекций у детей. Лики Украины. 2011; 3: 106-9.
- Thiruchelvam U, Wingfield M., O’Farrelly C. Natural killer cells: key players in endometriosis. Am. J. Reprod. Immunol. 2015; 74(4): 291-301. https://dx.doi. org/10.1111/aji.12408.
- Riccio L., Santulli P., Marcellin L., Abrao M.S., Batteux F., Chapron C. Immunology of endometriosis. Best Pract. Res. Clin. Obstet. Gynaecol. 2018; 50: 39-49. https://dx.doi.org/10.1016/j.bpobgyn.2018.01.010.
- Ярмолинская М.И., Айламазян Э.К. Генитальный эндометриоз. Различные грани проблемы. СПб.: Эко-Вектор; 2017: 150-1.
- Wong K.H., Simon J.A. In vitro effect of gonadotropin-releasing hormone agonist on natural killer cell cytolysis in women with and without endometriosis. Am. J. Obstet. Gynecol. 2014; 190(1): 44-9. https://dx.doi.org/10.1016/ j.ajog.2003.08.032.
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