Preimplantation genetic testing for aneuploidy in various protocols of assisted reproductive technologies with vitrified embryo


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Objective. To assess the effect of preimplantation genetic testing for aneuploidy (PGT-A) on the outcomes of assisted reproductive technologies (ART) cycles with vitrified embryo transfer in different protocols. Material and methods. This study analyzed 313 ART cycles with vitrified embryo and use of dydrogesterone for luteal phase support. These cycles were differentiated depending on the type of cryotransfer protocol and performance of PGT-A. The association of PGT-A and the outcome of the ART program with the vitrified embryo was evaluated depending on the type of protocol. Results. The protocols with the ovulatory cycle revealed a higher frequency of implantation in the cycles with PGT-A. The protocols with estrogens in the subgroup with PGT-A showed an increase in the frequency of implantation and a decrease in the proportion of pregnancy losses at the stage from biochemical to clinical pregnancy. GnRH agonist protocols demonstrated that the use of PGT-A was associated with a significant increase in the frequency of positive outcomes of the ART program (p=0.036). Conclusion. PGT-A positively affects the outcomes of ART programs with vitrified embryo and use of dydrogesterone for luteal phase support, improving their clinical outcomes.

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作者简介

Elena Kvashnina

Rehabilitation Center for Reproductive Disorders «Partus»

Email: doctor.kvashnina@gmail.com
PhD, leading reproductive specialist

Maks/m Tutakov

Rehabilitation Center for Reproductive Disorders «Partus»

Email: tutakov@ivf-partus.ru
Leading embryologist

Olesya Vakhlova

Rehabilitation Center for Reproductive Disorders «Partus»

Email: dr.vakhlova@mail.ru
obstetrician-gynecologist, fertility specialist

Evgenia Tomina

Rehabilitation Center for Reproductive Disorders «Partus»

Email: tomina@ivf-partus.ru
Deputy Director for Organizational and Methodological Work

Natalya Shilova

«Reprohelp» Ltd

Email: nvshilova@gmail.com
PhD, Director

参考

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