Experience with clotrimazole 2% cream in the therapy of vulvovaginal candidiasis: results of observational study


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Objective. To present the results of using of various clotrimazole dosage forms (2%, cream and 100 mg vaginal tablets) and its dosage regimens (for 3 and 6 days) in patients with vulvovaginal candidiasis. Subjects and methods. Examinations were made in 60 patients with vulvovaginal candidiasis, who were divided into 3 groups so that each group contained an equal number of people: 1) clotrimazole 2% cream as therapy for 3 days; 2) clotrimazole 2% cream for 6 days; 3) clotrimazole, 100 mg vaginal tablets for 6 days. The diagnosis was confirmed by the presence of Candida blastospores and pseudomycelium on microscopic examination and by the isolation of Candida albicans colonies on Sabouraud agar. The efficiency of therapy was evaluated after its completion, at 14 and 30 days. Results. After completion of therapy, the clinical signs of vulvovaginal candidiasis were absent in 95% of the patients in Group 1, in 100% in Group 2, and in 80% in Group 3; those of Candida pseudomycelium and blastospores were also absent in 18 (90%), 20 (100%), and 15 (75%) patients, respectively. After treatment, elevated leukocyte counts in vaginal discharge persisted only in 2 (10%) patients in Group 3; there was a growth of yeast-like fungi in the patients of Groups 1 (10%) and 3 (20%). The therapy resulted in a significant decrease in the frequency of isolation of opportunistic microorganisms in clinically significant amounts and in the normalization of the vaginal microflora in 90% of the examinees. Conclusion. The optimal profile of antimycotic and antimicrobial efficacy of clotrimazole 2% cream for intravaginal or topical use, which is superior to that when this agent is used as vaginal tablets, makes it possible to recommend it as one of the drugs of choice in the treatment of vulvovaginal candidiasis.

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作者简介

Margarita Rakhmatulina

State Research Center of the Russian Federation - A.I. Burnazyan Federal Medical and Biophysical Center, Federal Biomedical Agency of Russia

Email: ra.marg@yandex.ru
MD, professor, professor of the Department of dermatovenerology and cosmetology with a course of clinical laboratory diagnostics

Ellina Tarasenko

Moscow Research and Practical Center of Dermatovenereology and Cosmetology, Moscow Healthcare Department

Email: ellina.tarasenko@mail.ru
dermatovenerologist

Natalia Bolshenko

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; Moscow Regional Clinical Dermatoveneology Dispensary

Email: sanabol@mail.ru
candidate of medical sciences, the head researcher; Dermatovenerologist

参考

  1. Sherrard J., Wilson J., Donders G., Mendling W., Jensen J.S. 2018 European (IUSTI/WHO) International Union against sexually transmitted infections (IUSTI) World Health Organisation (WHO) guideline on the management of vaginal discharge. Int. J. STD & AIDS. 2018; 29(13): 1258-72. https://dx.d oi:10.1177/0956462418785451.
  2. Mendling W., Schlegelmilch R. Three-day combination treatment for vulvovaginal candidosis with 200 mg clotrimazole vaginal suppositories and clotrimazole cream for the vulva is significantly better than treatment with vaginal suppositories alone - an earlier, multicentre, placebo-controlled double blind study. Geburtsh Frauenheilk. 2014; 74: 355-60. 10.1055/s-0034-1368243' target='_blank'>https://dx.doi: 10.1055/s-0034-1368243.
  3. Workowski K.A., Bolan G.A.; Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm. Rep. 2015; 64(RR-03): 1-137.
  4. Canadian Guidelines on Sexually Transmitted Infections. 2016. Available at: https://www.canada.ca/en/public-health/services/infectious-diseases/sexual-health-sexually-transmitted-infections/canadian-guidelines.html
  5. Клинические рекомендации Российского общества дерматовенерологов и косметологов «Урогенитальный кандидоз». [Clinical guidelines of the Russian society of dermatovenerologists and cosmetologists “Urogenital candidiasis”. (in Russian)]. Available at: https://www.cnikvi.ru/docs/clinic_ recs/klinicheskie-rekomendatsii-2019-2020/
  6. Клинические рекомендации по диагностике и лечению заболеваний, сопровождающихся патологическими выделениями из половых путей женщин. [Clinical guidelines for the diagnosis and treatment of diseases accompanied by abnormal discharge from the genital tract of women. (in Russian)]. Available at: http://kolpotest.ru/uploaded/rekomendacii_roag.pdf
  7. Рахматулина М.Р., Тарасенко Э.Н. Частота выявления грибов рода Candida у пациентов с урогенитальным кандидозом и анализ показателей их антимикотической резистентности за десятилетний период (2010-2020 гг.). Акушерство и гинекология. 2020; 7: 159-65. https://dx.doi.org/10.18565/aig.2020.7.159-165. https://dx.doi.org/10.18565/aig.2020.7.159-165
  8. Willems H.M.E., Ahmed S.S., Liu J., Xu Z., Peters B.M. Vulvovaginal Candidiasis: a current understanding and burning questions. J. Fungi. (Basel). 2020; 6(1): 27. https://dx.doi.org/10.3390/jof6010027
  9. Greenbaum S., Greenbaum G., Moran-Gilad J., Weintruab A.Y. Ecological dynamics of the vaginal microbiome in relation to health and disease. Am. J. Obstet. Gynecol. 2019; 220(4): 324-35. https://dx.doi.org/10.1016/j. ajog.2018.11.1089.
  10. Santos C.M.A., Pires M.C.V., Leao T.L., Silva A.K.S., Miranda L.S., Martins F.S., Silva A.M., Nicoli J.R. Anti-inflammatory effect of two Lactobacillus strains during infection with Gardnerella vaginalis and Candida albicans in a HeLa cell culture model. Microbiology (Reading). 2018; 164(3): 349-58. https://dx.doi. org/10.1099/mic.0.000608.
  11. Ceccarani C., Foschi C., Parolin C., D'Antuono A., Gaspari V., Consolandi C. et al. Diversity of vaginal microbiome and metabolome during genital infections. Sci. Rep. 2019 (9): 14095. https://dx.doi.org/10.1038 / s41598-019-50410-x.
  12. Cools P., Jespers V., Hardy L., Crucitti T., Delany-Moretlwe S., Mwaura M. et al. A multi-country cross-sectional study of vaginal carriage of Group B Streptococci (GBS) and Escherichia coli in resource-poor settings: prevalences and risk factors. PLoS One. 2016; 11(1): e0148052. https://dx,doi.org/10.1371/journal. pone.0148052.

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