Effectiveness of donor-recipient ovarian stimulation programs in oocyte donors at different phases of the menstrual cycle

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Objective: To compare the effectiveness of donor-recipient programs for ovarian stimulation of oocyte donors during the follicular and luteal phases of the menstrual cycle.

Materials and methods: The study included 114 women:30 oocyte donors who underwent ovarian stimulation in both the follicular and luteal phases of the menstrual cycle and 84 recipients who underwent embryo transfer in a cryopreserved cycle. Donor oocytes were retrieved in the follicular and luteal phases in 36 and 48 of these recipients, respectively. The embryological parameters and clinical outcomes of the donor-recipient programs in both groups were evaluated.

Results: An analysis of the embryological parameters of the donor-recipient programs showed no difference in the fertilization rates of the donor oocytes received at different phases of the menstrual cycle, nor in the blastulation rates, number of high-quality blastocysts, and number of cryopreserved embryos. The pregnancy rate in recipients in cryopreserved cycles for embryo transfer, clinical pregnancy rate, reproductive loss rate up to 12 weeks, implantation rate, and live birth rate also did not differ significantly when donor oocytes obtained in the follicular and luteal phases of the cycle were used (p>0.05).

Conclusion: Ovarian stimulation of oocyte donors in the luteal phase of the menstrual cycle does not adversely affect embryological parameters and clinical outcomes of donor-recipient programs. In this context, the implementation of ovarian stimulation in the luteal phase of the cycle is important for different groups of patients to optimize the timing and increase the effectiveness of treatment.

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作者简介

Vera Lapina

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

编辑信件的主要联系方式.
Email: v_lapina@oparina4.ru

Obstetrician-Gynecologist at the 1st Gynecology Department

俄罗斯联邦, Moscow

Bella Martazanova

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Email: dr.bella.ivf@gmail.com

Ph.D., Senior Researcher at the 1st Gynecology Department

俄罗斯联邦, Moscow

Evelina Durinyan

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Email: evelina_durinyan@mail.ru

Ph.D., Senior Researcher at the 1st Gynecology Department

俄罗斯联邦, Moscow

Tatiana Amyan

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Email: t_amyan@oparina4.ru

Ph.D., Junior Researcher of the 1st Gynecology Department

俄罗斯联邦, Moscow

Anna Korolkova

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Email: korolkovaai@icloud.com

Ph.D., Researcher of the 1st Gynecology Department

俄罗斯联邦, Moscow

Alla Gavisova

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Email: a_gavisova@oparina4.ru

Head of the 1st Gynecology Department

俄罗斯联邦, Moscow

参考

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