Effectiveness of donor-recipient ovarian stimulation programs in oocyte donors at different phases of the menstrual cycle
- Authors: Lapina V.S.1, Martazanova B.A.1, Durinyan E.R.1, Amyan T.S.1, Korolkova A.I.1, Gavisova A.A.1
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Affiliations:
- Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
- Issue: No 9 (2023)
- Pages: 107-114
- Section: Original Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/622968
- DOI: https://doi.org/10.18565/aig.2023.153
- ID: 622968
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Abstract
Objective: To compare the effectiveness of donor-recipient programs for ovarian stimulation of oocyte donors during the follicular and luteal phases of the menstrual cycle.
Materials and methods: The study included 114 women:30 oocyte donors who underwent ovarian stimulation in both the follicular and luteal phases of the menstrual cycle and 84 recipients who underwent embryo transfer in a cryopreserved cycle. Donor oocytes were retrieved in the follicular and luteal phases in 36 and 48 of these recipients, respectively. The embryological parameters and clinical outcomes of the donor-recipient programs in both groups were evaluated.
Results: An analysis of the embryological parameters of the donor-recipient programs showed no difference in the fertilization rates of the donor oocytes received at different phases of the menstrual cycle, nor in the blastulation rates, number of high-quality blastocysts, and number of cryopreserved embryos. The pregnancy rate in recipients in cryopreserved cycles for embryo transfer, clinical pregnancy rate, reproductive loss rate up to 12 weeks, implantation rate, and live birth rate also did not differ significantly when donor oocytes obtained in the follicular and luteal phases of the cycle were used (p>0.05).
Conclusion: Ovarian stimulation of oocyte donors in the luteal phase of the menstrual cycle does not adversely affect embryological parameters and clinical outcomes of donor-recipient programs. In this context, the implementation of ovarian stimulation in the luteal phase of the cycle is important for different groups of patients to optimize the timing and increase the effectiveness of treatment.
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About the authors
Vera S. Lapina
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
Author for correspondence.
Email: v_lapina@oparina4.ru
Obstetrician-Gynecologist at the 1st Gynecology Department
Russian Federation, MoscowBella A. Martazanova
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
Email: dr.bella.ivf@gmail.com
Ph.D., Senior Researcher at the 1st Gynecology Department
Russian Federation, MoscowEvelina R. Durinyan
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
Email: evelina_durinyan@mail.ru
Ph.D., Senior Researcher at the 1st Gynecology Department
Russian Federation, MoscowTatiana S. Amyan
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
Email: t_amyan@oparina4.ru
Ph.D., Junior Researcher of the 1st Gynecology Department
Russian Federation, MoscowAnna I. Korolkova
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
Email: korolkovaai@icloud.com
Ph.D., Researcher of the 1st Gynecology Department
Russian Federation, MoscowAlla A. Gavisova
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
Email: a_gavisova@oparina4.ru
Head of the 1st Gynecology Department
Russian Federation, MoscowReferences
- McNatty K.P., Hillier S.G., van den Boogaard A.M., Trimbos-Kemper T.C., Reichert L.E., van Hall E.V. Follicular development during the luteal phase of the human menstrual cycle. J. Clin. Endocrinol. Metab. 1983; 56(5): 1022-31. https://dx.doi.org/10.1210/jcem-56-5-1022.
- Baerwald A.R., Adams G.P., Pierson R.A. Ovarian antral folliculogenesis during the human menstrual cycle: a review. Hum. Reprod. Update. 2012; 18(1): 73-91. https://dx.doi.org/10.1093/humupd/dmr039.
- Kirillova A., Martazanova B., Mishieva N., Semenova M. Follicular waves in ontogenesis and female fertility. Biosystems. 2021; 210: 104558. https://dx.doi.org/10.1016/j.biosystems.2021.104558.
- Bedoschi G.M., de Albuquerque F.O., Ferriani R.A., Navarro P.A. Ovarian stimulation during the luteal phase for fertility preservation of cancer patients: case reports and review of the literature. J. Assist. Reprod. Genet. 2010; 27(8): 491-4. https://dx.doi.org/10.1007/s10815-010-9429-0.
- Sönmezer M., Türkçüoğlu I., Coşkun U., Oktay K. Random-start controlled ovarian hyperstimulation for emergency fertility preservation in letrozole cycles. Fertil. Steril. 2011; 95(6): 2125.e9-11. https://dx.doi.org/10.1016/ j.fertnstert.2011.01.030.
- Cakmak H., Katz A., Cedars M.I., Rosen M.P. Effective method for emergency fertility preservation: random-start controlled ovarian stimulation. Fertil. Steril. 2013; 100(6): 1673-80. https://dx.doi.org/10.1016/j.fertnstert.2013.07.1992.
- Mishieva N., Martazanova B., Bogatyreva K., Korolkova A., Kirillova A., Veyukova M. et al. Cumulus cell gene expression in luteal-phase-derived oocytes after double stimulation in one menstrual cycle. Reprod. Biomed. Online. 2020; 41(3): 518-26. https://dx.doi.org/10.1016/j.rbmo.2020.05.002.
- Kuang Y., Chen Q., Hong Q., Lyu Q., Ai A., Fu Y. et al. Double stimulations during the follicular and luteal phases of poor responders in IVF/ICSI programmes (Shanghai protocol). Reprod. Biomed. Online. 2014; 29(6): 684-91. https://dx.doi.org/10.1016/j.rbmo.2014.08.009.
- Martinez F., Racca A., Rodríguez I., Polyzos N.P. Ovarian stimulation for oocyte donation: a systematic review and meta-analysis. Hum. Reprod. Update. 2021; 27(4): 673-96. https://dx.doi.org/10.1093/humupd/dmab008.
- Gardner D.K., Schoolcraft W.B. Culture and transfer of human blastocysts. Curr. Opin. Obstet. Gynecol. 1999; 11(3): 307-11. https://dx.doi.org/ 10.1097/00001703-199906000-00013.
- Богатырева Х.А., Мишиева Н.Г., Мартазанова Б.А., Лапина В.С., Абубакиров А.Н. Эффективность протоколов стимуляции функции яичников в различные фазы менструального цикла у пациенток со сниженным овариальным резервом. Акушерство и гинекология. 2017; 11: 78-83. [Bogatyreva Kh.A., Mishieva N.G., Martazanova B.A., Lapina V.S., Abubakirov A.N. Efficiency of ovarian stimulation protocols in different phases of menstrual cycle in patients with diminished ovarian reserve. Obstetrics and Gynecology. 2017; (11): 78-83. (in Russian)]. https://dx.doi.org/10.18565/aig.2017.11.78-83.
- Jochum F., Sananès N., Teletin M., Lichtblau I., Rongières C., Pirrello O. Luteal phase stimulation, the future of fertility preservation? Retrospective cohort study of luteal phase versus follicular phase stimulation. J. Gynecol. Obstet. Hum. Reprod. 2019; 48(2): 91-4. https://dx.doi.org/10.1016/j.jogoh.2018.11.003.
- Королькова А.И., Мишиева Н.Г., Мартазанова Б.А., Бурменская О.В., Веюкова М.А., Екимов А.Н., Трофимов Д.Ю., Абубакиров А.Н. Значимость копийности митохондриальной ДНК в клетках кумулуса пациенток позднего репродуктивного возраста. Акушерство и гинекология. 2019;10: 108-14. [Korolkova A.I., Mishieva N.G., Martazanova B.A., Burmenskaya O.V., Veyukova M.A., Ekimov A.N., Trofimov D.Yu., Abubakirov A.N. Implications of mitochondrial DNA copy number in cumulus cells in late reproductive-age women. Obstetrics and Gynecology. 2019; (10): 108-14. (in Russian)]. https://dx.doi.org/10.18565/aig.2019.10.108-114.
- Kalra S.K., Ratcliffe S., Gracia C.R., Martino L., Coutifaris C., Barnhart K.T. Randomized controlled pilot trial of luteal phase recombinant FSH stimulation in poor responders. Reprod. Biomed. Online. 2008; 17(6): 745-50. https://dx.doi.org/10.1016/s1472-6483(10)60400-2.
- Королькова А.И., Мишиева Н.Г., Мартазанова Б.А., БурменскаяО.В., Екимов А.Н., Трофимов Д.Ю., Веюкова М.А., Кириллова А.О., Абубакиров А.Н. Повышение эффективности программ ЭКО на основании определения копийности митохондриальной ДНК в трофэктодерме эмбрионов. Акушерство и гинекология. 2019; 3: 98-104. [Korolkova A.I., Mishieva N.G., Martazanova B.A., Bourmenskaya O.V., Ekimov A.N., Trofimov D.Yu., Veyukova M.A., Kirillova A.O., Abubakirov A.N. Increasing the effectiveness of IVF programs by determining mitochondrial DNA copy number in embryonic trophectoderm. Obstetrics and Gynecology. 2019; (3): 98-104. (in Russian)]. https://dx.doi.org/10.18565/aig.2019.3.98-104,
- Vaiarelli A., Cimadomo D., Alviggi E., Sansone A., Trabucco E., Dusi L. et al. The euploid blastocysts obtained after luteal phase stimulation show the same clinical, obstetric and perinatal outcomes as follicular phase stimulation-derived ones: a multicenter study. Hum. Reprod. 2020; 35(11): 2598-608. https://dx.doi.org/10.1093/humrep/deaa203.
- Королькова А.И., Мишиева Н.Г., Бурменская О.В., Екимов А.Н., Абубакиров А.Н., Богатырева Х.А. Современные методы селекции эмбрионов при проведении программ вспомогательных репродуктивных технологий. Акушерство и гинекология. 2018; 2: 13-8. [Korolkova A.I., Mishieva N.G., Burmenskaya O.V., Ekimov A.N., Abubakirov A.N., Bogatyreva Kh.A. Current embryo selection techniques in the implementation of assisted reproductive technology programs. Obstetrics and Gynecology. 2018; (2): 13-8. (in Russian)]. https://dx.doi.org/10.18565/aig.2018.2.13-18.
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