Pregestational and gestational diabetes mellitus as risk factors for predicting the development of congenital anomalies in newborns

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Objective: This study aimed to estimate the influence of maternal pregestational and gestational diabetes mellitus on the risk of congenital anomalies in newborns.

Materials and methods: We conducted a cohort study using data from the Murmansk and Arkhangelsk County birth registries, which contain information on the health of pregnant women and neonatal diaseses in newborns of 134,884 pregnancies.

Results: From 2006 to 2017, 4862 newborns with congenital anomalies were identified, resulting in a prevalence of 36.2 per 1,000 births. Pregnant women with pregestational diabetes mellitus had a higher risk of giving birth to babies with anomalies of the eye, ear, face, and neck, circulatory system, and other congenital anomalies (Q80-Q89), including multiple anomalies. Pregnant women with gestational diabetes mellitus had a higher risk of having children with respiratory system anomalies.

Conclusion: Diabetes mellitus in women increases the risk of congenital anomalies in their children. Prognostic models developed to determine the risk of congenital anomalies should include information regarding the presence of maternal diabetes.

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作者简介

Vitaly Postoev

Northern State Medical University, Ministry of Health of the Russian Federation

编辑信件的主要联系方式.
Email: ispha@nsmu.ru
ORCID iD: 0000-0003-4982-4169

Cand. Sci. (Med), Ph.D., Acting Head of the Department of Methodology of Scientific Research, Head of the Arkhangelsk International School of Public Health Northern State Medical University

俄罗斯联邦, 163069, Arkhangelsk, Troitsky Ave., 51

Alena Telkova

Northern State Medical University, Ministry of Health of the Russian Federation

Email: ispha@nsmu.ru
ORCID iD: 0009-0002-1472-0546
俄罗斯联邦, 163069, Arkhangelsk, Troitsky Ave., 51

Polinа Maevskaya

Northern State Medical University, Ministry of Health of the Russian Federation

Email: ispha@nsmu.ru
ORCID iD: 0009-0004-4486-6225
俄罗斯联邦, 163069, Arkhangelsk, Troitsky Ave., 51

Anna Postoeva

Northern State Medical University, Ministry of Health of the Russian Federation

Email: ispha@nsmu.ru
ORCID iD: 0000-0003-3749-0173

Cand. Sci. (Med),Associate Professor at the Department of Hospital Therapy and Endocrinology

俄罗斯联邦, 163069, Arkhangelsk, Troitsky Ave., 51

Anna Usynina

Northern State Medical University, Ministry of Health of the Russian Federation

Email: perinat@mail.ru
ORCID iD: 0000-0002-5346-3047

Dr. Med. Sci., Ph.D., Head of the Department of Neonatology and Perinatology

 

俄罗斯联邦, 163069, Arkhangelsk, Troitsky Ave., 51

Andrej Grjibovski

Northern State Medical University, Ministry of Health of the Russian Federation; Northern (Arctic) Federal University named after M.V. Lomonosov

Email: a.grjibovski@yandex.ru
ORCID iD: 0000-0002-5464-0498

MD, Head of the Division for Research and Innovations, Chief researcher at the Arctic biomonitoring laboratory Northern (Arctic) Federal University

俄罗斯联邦, 163069, Arkhangelsk, Troitsky Ave., 51; 163001, Arkhangelsk, 17 Severnaya Dvina Emb.

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