Treatment for cyclic mastodynia in patients with benign breast diseases

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Objective: To evaluate the efficacy of indole carbinol medication (Indinol Forto) in treating benign breast dysplasia (BBD).

Materials and methods: The study included 274 women aged 29–52 years who presented with complaints of breast pain: group A consisted of 109 women with BBD (BI-RADS 2) who were prescribed complex treatment with indole carbinol-based medication; group B included 79 patients with BBD (BI-RADS 3) who underwent surgery followed by complex treatment with indole carbinol-based medication; group C consisted of 86 women with BBD (BI-RADS 2) who refused to receive medical treatment.

Results: At the end of the six-month course of treatment with indole carbinol, there was a significant improvement in health and a decrease or disappearance of mastalgia: only 8.3% of women in group A (p1<0.001), 12.6% of women in group B (p2<0.001), and 76.7% of women in group C had complaints of mastodynia. Mild mammographic density was noted in 74.3% of patients in group A, in 72.3% of women in group B and in 46.5% of patients in group C (p1<0.001, p2<0.001); moderate density was noted in 20.1%, 19.0% and 32.6% of patients (p1=0.050, p2=0.048), respectively; severe density was noted in 3.7%, 3.8% and 12.8% of women (p1=0.018, p2=0.039), respectively; very severe density was noted in 1.8%, 1.3% and 8.1% of patients (p1=0.038, p2=0.041), respectively.

Conclusion: Indole carbinol medication may be recommended for widespread use as a first-line medication in women with increased breast density.

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作者简介

Elena Kravchenko

Omsk State Medical University, Ministry of Health of Russia

编辑信件的主要联系方式.
Email: kravchenko.en@mail.ru

Dr. Med. Sci., Professor, Professor at the Department of Obstetrics and Gynecology No. 1

俄罗斯联邦, Omsk

Maxim Naboka

Omsk State Medical University, Ministry of Health of Russia; Clinical Medical and Sanitary Unit No. 7

Email: nabokamax@mail.ru

Assistant, Department of Oncology, Radiation Therapy, oncologist at the Center for Outpatient Oncological Care

俄罗斯联邦, Omsk; Omsk

Maxim Sosnin

Odintsovo Regional Hospital

Email: maxim.nervik@gmail.com

oncologist, Head of the Day Hospital of the Oncological Department of Drug Antitumor Therapy

俄罗斯联邦, Odintsovo

Maria Tsygankova

N.N. Petrov National Medical Research Center of Oncology, Ministry of Health of Russia

Email: tsygankovva98@mail.ru

2nd year clinical resident with a degree in oncology

俄罗斯联邦, St. Petersburg

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2. Fig. 1. Mastodynia before and after treatment in the study groups. Note: p1 <0.001, p1 – level of significance between groups A and B; р2<0.001, р2– significance level between groups B and C

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3. Fig. 2. Dynamics of mammographic density in women in group A before treatment and after 6 months

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4. Fig. 3. Dynamics of mammographic density in women in group B before treatment and after 6 months

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5. Fig. 4. Dynamics of mammographic density in women in group B before treatment and after 6 months

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