Early endometrial cancer in patients with congenital malformation of the genital organs

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Relevance: Double uterus in combination with early endometrial cancer is a very rare pathology which should be treated with extirpation of the uterus with appendages. However, it is possible to perform organ sparing hormonal treatment for reproductive-aged women who want to preserve fertility resulting in pregnancy and childbirth.

Case report: This article presents a clinical case of a patient with the double uterus in combination with early endometrial cancer who underwent a course of organ sparing hormonal therapy in order to achieve conception, become pregnant and give birth. A 28-year-old patient presented to the V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Moscow for a consultation and pregnancy planning. The comprehensive examination of the patient led to the diagnosis of highly differentiated stage Ia endometrial cancer of the right uterus and atypical hyperplasia of the endometrium of the left uterus. The patient refused surgical treatment; therefore, a course of organ sparing hormonal therapy was prescribed, which resulted in pregnancy and the birth of a healthy full-term girl.

Conclusion: Organ sparing hormonal therapy in reproductive-aged women with confirmed diagnosis of early endometrial cancer, as well as with malformation of the genital organs, makes it possible for women to preserve fertility, achieve pregnancy and reduce the risk of recurrence of the disease after childbirth and breastfeeding.

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作者简介

Arina Dvoynishnikova

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

编辑信件的主要联系方式.
Email: arina.dvoynishnikova@mail.ru

Clinical Resident at the Department of Obstetrics and Gynecology

俄罗斯联邦, Moscow

Zalina Shebzukhova

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: shbzkhv@gmail.com

Oncologist, Obstetrician-Gynecologist, post-graduate at the Department of Innovative Oncology and Gynecology

俄罗斯联邦, Moscow

Stanislav Pronin

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: psm_doc@mail.ru

PhD, Oncologist, Obstetrician-Gynecologist, Senior Researcher at the Department of Innovative Oncology and Gynecology

俄罗斯联邦, Moscow

Grigory Khabas

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: g_khabas@oparina4.ru

PhD, Head of the Department of Combined and Complex Methods of Treatment of Gynecological Diseases

俄罗斯联邦, Moscow

参考

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2. Fig. 1. Endometrial polyp in the right uterus

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3. Fig. 2. Atypical endometrial hyperplasia in the left uterus

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4. Fig. 3. Endometrial atrophy

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