Early endometrial cancer in patients with congenital malformation of the genital organs

Relevance: Double uterus in combination with early endometrial cancer is a very rare pathology which should be treated with extirpation of the uterus with appendages. However, it is possible to perform organ sparing hormonal treatment for reproductive-aged women who want to preserve fertility resulting in pregnancy and childbirth.

Case report: This article presents a clinical case of a patient with the double uterus in combination with early endometrial cancer who underwent a course of organ sparing hormonal therapy in order to achieve conception, become pregnant and give birth. A 28-year-old patient presented to the V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Moscow for a consultation and pregnancy planning. The comprehensive examination of the patient led to the diagnosis of highly differentiated stage Ia endometrial cancer of the right uterus and atypical hyperplasia of the endometrium of the left uterus. The patient refused surgical treatment; therefore, a course of organ sparing hormonal therapy was prescribed, which resulted in pregnancy and the birth of a healthy full-term girl.

Conclusion: Organ sparing hormonal therapy in reproductive-aged women with confirmed diagnosis of early endometrial cancer, as well as with malformation of the genital organs, makes it possible for women to preserve fertility, achieve pregnancy and reduce the risk of recurrence of the disease after childbirth and breastfeeding.