Vol 23, No 4 (2017)

The article presents the results of analysis of morbidity of diseases of digestive organs шт the Republic of Armenia. It is established that in the Republic of Armenia during 1990-2015 primary morbidity of diseases of digestive organs in children population reliably increased up to 2.4 times and in adult population - up to 1.9 times. The leading diseases in the structure of primary morbidity among children population is gastroduodenitis (39.7%) and among adult population - gastritis (54.6%). In the Republic, the indices of total morbidity of diseases of digestive organs during the same period of time increased reliably from 57,5‰ to 100,3‰ in children population and from 50,9‰ to 60,2‰ adult population. At the same time, during last 15 years at stabilization of level of morbidity with temporary disability average duration of one case of disease with temporary disability up to 11.6% and primary disability up to 2.9%.

The study was carried out on the basis of sampling of able-bodied individuals to analyze indices of arterial rigidity obtained at screening examination (group I, 138 patients) combined with day monitoring of arterial pressure (group II, 58 patients). The conclusion is made that in-depth examination of individuals with arterial hypertension and risk of cardio-vascular complications day monitoring of arterial pressure with estimation of arterial rigidity is preferable to be applied.

The problem of chronic obstructive pulmonary disease of lungs is actual and has no tendency to be resolved. The chronic obstructive disease of lungs is characterized by multitude of systemic manifestations. However, mechanisms of development of edematous syndrome under chronic obstructive pulmonary disease of lungs are studied insufficiently. The purpose. To study pathogenetic mechanisms of development of edematous syndrome in patients suffering of chronic obstructive pulmonary disease of lungs. Material and methods. The sampling of 35 patients with exacerbation of chronic obstructive disease of lungs was used to analyze structure and functions of heart, gas composition of arterial blood, functional conditions of kidneys. The cohort of patients was separated on group A and group B depending on response to start therapy. The patients with weak response to start therapy continued to receive respiratory support as an addition to medicinal therapyThe results. The groups of patients are comparable on anamnestic and clinical parameters. The patients of group B suffered from intensive edematous syndrome, and more intensive cyanosis. The patients from group A suffered from less intensive edema. The edema was present not in all patients. The parameters characterizing functional condition of heart had no group difference. The disturbances of gas composition of arterial blood and function of kidneys were less intensive in group B than in group A. The analysis of correlations established that intensity of edematous syndrome is directly related to velocity of glomerular filtration and velocity of glomerular filtration depended on parameters of gas exchangeConclusion. In patients with exacerbation of chronic obstructive pulmonary disease of lungs at retained systolic function of left ventricle development of edematous syndrome is conditioned by renal dysfunction.

The results of clinical metabolic examination of women with diabetes mellitus type II and patients with obesity degree III-IV testify increasing of level of cholesterol, triglycerides, low density lipoproteins and very low density lipoproteins and also coefficient of atherogenity in comparison with control group. These alterations permit to affirm that diabetes mellitus type II in women also as obesity is accompanied by dislipidemia of atherogenic character. At that, in patients with diabetes mellitus type II more intensive alterations of quantitative composition of lipids, including fat acid composition of blood is established. The obesity and diabetes mellitus type II are accompanied by modification of composition of free and esterified fatty acids of blood erythrocytes, increasing of peroxidation of lipids that can result in alteration of functional activity of membranes and in damage of insulin-binding activity of cyto-membranes. The disorder of metabolism of fatty acids accompanied by increasing of concentration of free radicals and decreasing of activity of enzymes of anti-oxidant defense results in decreasing of insulin-binding activity of cells and disorder of processes of glucose utilization.

The article summarizes the results of expertise analysis of nomenclature of Russian pharmaceutical market of anti-tumor medications. the main summing-up is presented concerning implementation of strategy of medicinal support of oncologic patients within the framework of program "The strategy of development of pharmaceutical industry of the Russian Federation up to 2020".