Vol 23, No 4 (2017)

Articles
THE DYNAMICS OF PREVALENCE OF DISEASES OF DIGESTIVE ORGANS IN POPULATION OF THE REPUBLIC OF ARMENIA
Miridzhanyan G.M., Polunina N.V.
Abstract
The article presents the results of analysis of morbidity of diseases of digestive organs шт the Republic of Armenia. It is established that in the Republic of Armenia during 1990-2015 primary morbidity of diseases of digestive organs in children population reliably increased up to 2.4 times and in adult population - up to 1.9 times. The leading diseases in the structure of primary morbidity among children population is gastroduodenitis (39.7%) and among adult population - gastritis (54.6%). In the Republic, the indices of total morbidity of diseases of digestive organs during the same period of time increased reliably from 57,5‰ to 100,3‰ in children population and from 50,9‰ to 60,2‰ adult population. At the same time, during last 15 years at stabilization of level of morbidity with temporary disability average duration of one case of disease with temporary disability up to 11.6% and primary disability up to 2.9%.
Medical Journal of the Russian Federation. 2017;23(4):172-174
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THE SIGNIFICANCE OF HIGH-SENSITIVE TROPONIN I UNDER VARIOUS FORMS OF INFECTIOUS ENDOCARDITIS
Fedorova T.A., Tazina S.Y., Gerasimov A.N., Semenenko N.A.
Abstract
The study was carried out to analyze dynamics of highly sensitive Troponin I in patients with infectious endocarditis with the purpose of specifying its role in evaluation of myocardium condition and prognosis of disease. The sampling included 241 patients being on treatment in the S.P. Botkin municipal clinical hospital. The article presents characteristics of disease at actual stage, clinical laboratory and instrumental comparisons permitted to establish features and patterns of alterations of hsTnI in patients with primary and secondary infectious endocarditis. The relationship is established between increasing of indicator and clinical expression of infectious toxic syndrome, presence of complications, multi-functional alterations of myocardium and functional class of cardiac insufficiency. It is demonstrated that absence of positive dynamics of marker against the background of therapy is a unfavorable prognostic indication and increases a risk of lethal outcome.The obtained results testify undeniable involvement of cardiac muscle into development of pathological process under infectious endocarditis that alongside with valvular pathology determines severity of cardiac insufficiency and prognosis of disease.
Medical Journal of the Russian Federation. 2017;23(4):175-181
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THE STUDY OF ARTERIAL RIGIDITY IN OUT-PATIENT PRACTICE AMONG INDIVIDUALS OF ABLE-BODIED AGE
Dokina E.D., Shashina N.B., Babanin V.S., Minushkina L.O., Alekseeva L.A.
Abstract
The study was carried out on the basis of sampling of able-bodied individuals to analyze indices of arterial rigidity obtained at screening examination (group I, 138 patients) combined with day monitoring of arterial pressure (group II, 58 patients). The conclusion is made that in-depth examination of individuals with arterial hypertension and risk of cardio-vascular complications day monitoring of arterial pressure with estimation of arterial rigidity is preferable to be applied.
Medical Journal of the Russian Federation. 2017;23(4):181-184
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THE REGULATORY ADAPTIVE STATUS IN TESTING EFFICIENCY OF THERAPY WITH BISOPROSOL AND NEBIVOLOL IN PATIENTS WITH PAROXYSMAL SUPRA-VENTRICULAR TACHYCARDIA AND HYPERTENSION DISEASE
Nazhalkina N.M., Tregubov V.G., Pokrovskiy V.M.
Abstract
The purpose. To compare efficiency of application of Bisoprosol and Nebivolol in patients with paroxysmal supra-ventricular tachycardia against the background of hypertension disease considering their effect on regulatory adaptive status.Materials and method. The sampling consisted of 50 patients with paroxysmal supra-ventricular tachycardia against the background of hypertension disease stage I-II randomized to two groups for treatment with Bisoprosol (3,9±1,3 mg per day, n=25) or Nebivolol (3,8±1,2 mg per day, n=25). The combined therapy provided Lisinopril (7,5±2,5 and 7,4±2,4 mg per day)and in case of indications - Atorvastatin (15,4±3,8 mg per day, n=9 и 15,9±4,1 mg per day, n=9) and acetylsalicylic acid (91,5±14,7 mg per day, n=12 и 93,1±16,2 mg per day, n=14) correspondingly. Initially and after 6 months quantitative evaluation of regulatory adaptive status (by means of testing cardio-respiratory synchronism), echocardiography, triplex scanning of brachiocephalic arteries, six minutes walk testing, tredmilmetry, day monitoring of arterial pressure and electrocardiograms, subjective evaluation of life quality were implemented.Results. It is established that both schemes of combined therapy had comparable effect, controlled arterial hypertension, ameliorated functional and structural condition of heart. The application of Nebivolol positively effected regulatory adaptive status and in a greater degree increases tolerance to physical load and ameliorated life quality.Conclusion. The application of Nebivolol as compared with Bisoprosol in combined therapy is more preferable in patients with paroxysmal supra-ventricular tachycardia against the background of hypertension disease stage II-III due to positive effect of regulatory adaptive status.
Medical Journal of the Russian Federation. 2017;23(4):185-191
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THE EDEMATOUS SYNDROME IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE OF LUNGS: MECHANISMS OF DEVELOPMENT AND APPROACHES TO TREATMENT
Kirillova D.A., Tatarsky A.R.
Abstract
The problem of chronic obstructive pulmonary disease of lungs is actual and has no tendency to be resolved. The chronic obstructive disease of lungs is characterized by multitude of systemic manifestations. However, mechanisms of development of edematous syndrome under chronic obstructive pulmonary disease of lungs are studied insufficiently. The purpose. To study pathogenetic mechanisms of development of edematous syndrome in patients suffering of chronic obstructive pulmonary disease of lungs. Material and methods. The sampling of 35 patients with exacerbation of chronic obstructive disease of lungs was used to analyze structure and functions of heart, gas composition of arterial blood, functional conditions of kidneys. The cohort of patients was separated on group A and group B depending on response to start therapy. The patients with weak response to start therapy continued to receive respiratory support as an addition to medicinal therapyThe results. The groups of patients are comparable on anamnestic and clinical parameters. The patients of group B suffered from intensive edematous syndrome, and more intensive cyanosis. The patients from group A suffered from less intensive edema. The edema was present not in all patients. The parameters characterizing functional condition of heart had no group difference. The disturbances of gas composition of arterial blood and function of kidneys were less intensive in group B than in group A. The analysis of correlations established that intensity of edematous syndrome is directly related to velocity of glomerular filtration and velocity of glomerular filtration depended on parameters of gas exchangeConclusion. In patients with exacerbation of chronic obstructive pulmonary disease of lungs at retained systolic function of left ventricle development of edematous syndrome is conditioned by renal dysfunction.
Medical Journal of the Russian Federation. 2017;23(4):191-196
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THE CHLAMYDIA INFECTION OF UPPER SECTION OF RESPIRATORY TRACTS
Markina A.N., Kapustina T.A., Parilova O.V., Belova E.V.
Abstract
The chlamydiae, according human danger degree, are absolute parasites with all attributes of virulence. Besides possibility of reiterated infection, they are not classified as opportunistic microorganisms, constituting facultative part of microflora of normal biocenosis of mucous tunics. The article presents data concerning high prevalence of chlamydia infection of upper section of respiratory tract in various groups of populations (organized children and adult population, patients with acute and chronic inflammatory disease of nose, paranasal sinuses and nasopharynx). The obtained results are based on examination of 1 329 individuals. The laboratory analysis techniques included identification of two types of chlamydiae - Chlamydia trachomatis and Chlamydophila pneumoniae. To detect chlamydiae in organized population a direct fluoroimmunoassay was applied. The verification of chlamydia infection on patients was implemented by simultaneous application of three tests: direct fluoroimmunoassay (to detect antigens of chlamydia), polymerase chain reaction (to detect DNA chlamydiae) and enzyme-linked immunosorbent assay (to detect anti-chlamydiae antibodies). The species structure of identified chlamydiae depending on age and gender of examined individuals was presented. It was established that infection with chlamydiae of mucous membrane of upper section of respiratory tract depends on age of child. The presence of chlamydiae in children and adults determines higher probability of development of ENT pathology.
Medical Journal of the Russian Federation. 2017;23(4):197-200
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THE METABOLIC DISORDERS IN MEMBRANE OF ERYTHROCYTES AND INSULIN-BINDING ACTIVITY OF BLOOD CELLS IN PATIENTS UNDER OBESITY AND DIABETES MELLITUS TYPE II
Mikaelyan N.P., Potemkin V.V.
Abstract
The results of clinical metabolic examination of women with diabetes mellitus type II and patients with obesity degree III-IV testify increasing of level of cholesterol, triglycerides, low density lipoproteins and very low density lipoproteins and also coefficient of atherogenity in comparison with control group. These alterations permit to affirm that diabetes mellitus type II in women also as obesity is accompanied by dislipidemia of atherogenic character. At that, in patients with diabetes mellitus type II more intensive alterations of quantitative composition of lipids, including fat acid composition of blood is established. The obesity and diabetes mellitus type II are accompanied by modification of composition of free and esterified fatty acids of blood erythrocytes, increasing of peroxidation of lipids that can result in alteration of functional activity of membranes and in damage of insulin-binding activity of cyto-membranes. The disorder of metabolism of fatty acids accompanied by increasing of concentration of free radicals and decreasing of activity of enzymes of anti-oxidant defense results in decreasing of insulin-binding activity of cells and disorder of processes of glucose utilization.
Medical Journal of the Russian Federation. 2017;23(4):201-204
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THE CLINICAL SOCIAL FACTORS EFFECTING ON HETERO-AGGRESSIVE BEHAVIOR OF WOMEN SERVING A SENTENCE IN CORRECTIONAL INSTITUTION
Shaklein K.N., Bardenshteyn L.M.
Abstract
On the basis of comparative analysis of social and clinical factors in 435 women with hetero-aggressive behavior and 321 women without aggressive behavior serving a sentence in correctional institution new data was obtained concerning relationship between social and clinical factors and aggression. The dominant role of social environment factors in comparison with common social factors in development of both aggression and mental deviations is demonstrated. The conclusion is made that social environment factors are an important component of factors' triad (clinical, personal, social) in many ways determining development of aggressive inclinations in women.
Medical Journal of the Russian Federation. 2017;23(4):205-212
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THE SUPPORT OF RUSSIAN PATIENTS WITH ANTI-TUMOR MEDICATIONS
Golikov A.S.
Abstract
The article summarizes the results of expertise analysis of nomenclature of Russian pharmaceutical market of anti-tumor medications. the main summing-up is presented concerning implementation of strategy of medicinal support of oncologic patients within the framework of program "The strategy of development of pharmaceutical industry of the Russian Federation up to 2020".
Medical Journal of the Russian Federation. 2017;23(4):213-219
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THE ABDOMINAL PAIN SYNDROME IN CHILDREN: DIFFERENTIAL DIAGNOSTIC APPROACHES
Artamonov R.G.
Abstract
The article considers the problem of differential diagnostic of abdominal pain syndrome. The actuality of this issue is conditioned by high rate of diagnostic errors at this most widespread complain among children. The long-term practical experience was involved to develop algorithms for solution of this difficult diagnostic task.
Medical Journal of the Russian Federation. 2017;23(4):220-224
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