Studies of secondary metabolites from marine sponges in the Laboratory of the Chemistry of Marine Natural Compounds of PIBOC FEB RAS in 2019–2023

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Abstract

Sea sponges are among the richest sources of biologically active compounds. Among them, terpenoids, alkaloids, polyketides, peptides, steroids, amino acids and other classes of compounds were found. They exhibit a wide range of biological activities such as cytotoxic, antitumor, antibacterial, antifungal, antiviral, anti-inflammatory, antioxidant, enzyme inhibitory and antimalarial. This review covers the structures and biological activities of secondary metabolites isolated from marine sponges in the Laboratory of the Chemistry of Marine Natural Compounds of the Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences and published in 2019–2023.

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About the authors

Sergey N. Fedorov

Elyakov Pacific Institute of Bioorganic Chemistry of FEB RAS

Author for correspondence.
Email: fedorov@piboc.dvo.ru
ORCID iD: 0000-0001-7318-8866

Doctor of Sciences in Chemistry, Leading Researcher

Russian Federation, Vladivostok

Tatiana N. Makarieva

Elyakov Pacific Institute of Bioorganic Chemistry of FEB RAS

Email: makarieva@piboc.dvo.ru
ORCID iD: 0000-0002-2446-8543

Doctor of Sciences in Chemistry, Major Researcher

Russian Federation, Vladivostok

Alla G. Guziy

Elyakov Pacific Institute of Bioorganic Chemistry of FEB RAS

Email: gagry@rambler.ru

Candidate of Sciences in Chemistry, Senior Researcher

Russian Federation, Vladivostok

Larisa K. Shubina

Elyakov Pacific Institute of Bioorganic Chemistry of FEB RAS

Email: shubina@piboc.dvo.ru

Candidate of Sciences in Chemistry, Senior Researcher

Russian Federation, Vladivostok

Ksenia M. Tabakmacher

Elyakov Pacific Institute of Bioorganic Chemistry of FEB RAS

Email: tabakmakher_km@piboc.dvo.ru

Candidate of Sciences in Chemistry, Researcher

Russian Federation, Vladivostok

Ekaterina K. Kudryashova

Elyakov Pacific Institute of Bioorganic Chemistry of FEB RAS

Email: catrinog.81@mail.ru
ORCID iD: 0009-0006-8911-6377

Junior Researcher

Russian Federation, Vladivostok

Elena A. Santalova

Elyakov Pacific Institute of Bioorganic Chemistry of FEB RAS

Email: santalova@piboc.dvo.ru
ORCID iD: 0000-0001-9503-4833

Candidate of Sciences in Chemistry, Senior Researcher

Russian Federation, Vladivostok

Sophia A. Kolesnikova

Elyakov Pacific Institute of Bioorganic Chemistry of FEB RAS

Email: sovin81@inbox.ru
ORCID iD: 0000-0002-4405-8496

Candidate of Sciences in Chemistry, Senior Researcher

Russian Federation, Vladivostok

Anastasia B. Kozhushnaya

Elyakov Pacific Institute of Bioorganic Chemistry of FEB RAS

Email: kozhushnaia.ab@mail.ru
ORCID iD: 0000-0001-7974-8158

Junior Researcher

Russian Federation, Vladivostok

Natalia V. Ivanchina

Elyakov Pacific Institute of Bioorganic Chemistry of FEB RAS

Email: ivanchina@piboc.dvo.ru
ORCID iD: 0000-0001-9075-8584

Candidate of Sciences in Chemistry, Head of Laboratory

Russian Federation, Vladivostok

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Supplementary files

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2. Fig. 1. Structures of guanidine alkaloids 1-5 isolated from the marine sponge Monanchora pulchra

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3. Fig. 2. Structures of oceanalins B (6) and A (7) isolated from the marine sponge Oceanapia sp.

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4. Fig. 3. Structures of toporosides A-D (8-11) from the marine sponge Stelodoryx toporoki

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5. Fig. 4. Structure of assimiloside A (12) from the marine sponge Hymeniacidon assimilis

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6. Fig. 5. Structures of new 1-O-alkylglycerol esters (13-18) from the marine sponge Guitarra abbotti

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7. Fig. 6. Structures of oxidised cerebrosides from the marine sponge Aulosaccus sp.

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8. Fig. 7. Ceramide structures from the sponge Monanchora clathrata

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9. Fig. 8. Structure of rhizochalinin (28)

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10. Fig. 9. Structures of steroids 29-38 from the marine sponge Halichondria vansoesti

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11. Fig. 10. Structures of gracilosulphates A-G (39-45) from the marine sponge Haliclona gracilis

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12. Fig. 11. Structures of steroids from the marine sponge Aulosaccus sp.

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13. Fig. 12. Structures of cyclobutastellolides A (57) and B (58) from the marine sponge Rhabdastrella globostellata

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14. Fig. 13. Structures of stellettins Q-V (59-64) and globostelletin N (65) from the marine sponge Rhabdastrella globostellata

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15. Fig. 14. Structures of rhabdastrellosides A and B (66 and 67) from the marine sponge Rhabdastrella globostellata

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16. Fig. 15. Structures of diterpenoids (68-73) from the marine sponge Spongionella sp.

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