THE CHANGE OF HUMORAL AND CELLULAR IMMUNE RESPONSES, OF TH1-, TH2- LYMPHOCYTES FUNCTIONS AND CYTOKINE CONCENTRATIONS IN BLOOD AFTER CHRONIC INTOXICATION WITH TRICHLOROETHYLENE

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Abstract

It was established in experiments on non-inbred albino rats that chronic intoxication with trichlorethylene (30 days, subcutaneously daily 0.05 LD50) ) largely decreased Th2- cells activity as compared to Th1-lyphocytes and as well as humoral immune responses as compared to the cellular immune response. Trichloroethylene decreased levels of immune regulatory cytokines IFN-γ, IL-2, IL-4 in blood ,increased the concentration of pro-inflammatory cytokine IL-6, and insignificantly raised levels of anti-inflammatory cytokines IL-10, IL-13 in blood.

About the authors

P. F. Zabrodskii

Author for correspondence.
Russian Federation

V. V. Maslyakov

Russian Federation

M. S. Gromov

Russian Federation

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