Ultrasound Ablation: New Possibilities for Treatment of Bone and Soft-Tissue Tumors


Focused high intensity ultrasound (HIFU) with sighting influence on tumor enabled to cause its complete coagulative necrosis without damage to intact environmental tissues. The possibilities of ultrasound ablation as the method of local treatment of bone and soft-tissue tumor were considered. Physical principles of method, criteria for patient selection, treatment technique as well as clinical outcomes and their evaluation were presented. Advantages of method are non-invasiveness, less traumatization, less technical complexity and dependence on surgeon skill compared with other sparing operations and methods of ablation. When necessary HIFU may be repeated several times. Effect of HIFU is independent on tumor type. Possible complications (secondary infection in coagulative necrosis zone, peripheral nerves damage, pathological fractures) and measures of their prevention are presented.


  1. Алиев М.Д., Соколовский В.А. Злокачественные опухоли костей. Современные принципы диагностики и лечения. //Профилактика, ранняя диагностика и лечение злокачественных новообразований. - М., 2005. - С. 115-126.
  2. Махсон Н.Е., Махсон А.Н. Адекватная хирургия при опухолях плечевого и тазового пояса. - М., 1998.
  3. Махсон А.Н., Махсон Н.Е. Адекватная хирургия опухолей конечностей. - М., 2001.
  4. Соболевский В.А. Реконструктивная хирургия в лечении больных с местно распространенными опухолями костей, кожи и мягких тканей: Дис. ... д-ра мед. наук. - М., 2008.
  5. Соколовский В.А., Мусаев Э.Р., Соболевский В.А. и др. Принципы хирургического лечения опухолей костей //Злокачественные опухоли костей /Под ред. М.Д. Алиева. - М., 2008. - С. 177-294.
  6. Cannon C.P., Ballo M.T., Zagars G.K. et al. Complications of combined modality treatment of primary lower extremity soft-tissue sarcomas //Cancer. - 2006. - Vol. 107, N 10. - P. 2455-2461.
  7. Сlement G.T. Perspectives in clinical uses of high-intensity focused ultrasound //Ultrasonics. - 2004. - Vol. 42. - P. 1087-1093.
  8. Chen W.Z., Wang W., Zhu H. et al. Clinical follow-up reports on high-intensity focused ultrasound treatment of osteosarcoma //Proceedings of 4th Int. Symp. on therapeutic ultrasound. - Kyoto, 2004.
  9. Chen W.Z., Wang Z.B., Wu F. et al. High intensity focused ultrasound in the treatment of primary malignant bone tumour //Chin. J. Oncol. - 2002. - Vol. 24. - P. 612-615.
  10. Chen W.Z., Wang Z.B., Wu F. et al. High intensity focused ultrasound alone for malignant solid tumors //Chin. J. Oncol. - 2002 - Vol. 24. - P. 278-281.
  11. Chen W.Z., Wu F., Zhu H. et al. Preliminary study on high intensity focused ultrasonic treatment of osteo-sarcoma //Chin. J. Clin. Oncol. - 2001. - Vol. 28. - P. 489-491.
  12. Chen W.Z., Zhou K. High-intensity focused Ultrasound ablation. A new Strategy to manage primary bone tumors //Curr. Opin. Orthop. - 2005. - Vol. 16. - P. 404-500.
  13. Delon-Martin C., Vogt C., Chignier E. et al. Venous thrombosis generation by means of high-intensity focused ultrasound //Ultrasound. Med. Biol. - 1995. - Vol. 21. - P. 113-119.
  14. Eckardt J.J., Kabo J.M., Kelley C.M. Expandable endoprosthesis reconstruction in skeletally immature patients with tumors //Clin. Orthop. - 2000. - N 373. - P. 5161.
  15. Ham S.J., Schraffordt Koops H., Veth R.P. et al. Limb salvage surgery for primary bone sarcoma of the lower extremities: long-term consequences of endoprosthetic reconstruction results //Ann. Surg. Oncol. - 1998. - Vol. 5. - P. 423-436.
  16. Hill C.R., Rivens I., Vaughan M. et al. Lesion development in focused ultrasound surgery: a general model //Ultrasound. Med. Biol. - 1994. - Vol. 20. - P. 259-269.
  17. Hynynen K., Chung A., Colucci V. et al. Potential adverse effects of high-intensity focused ultrasound exposure on blood vessels in vivo //Ultrasound. Med. Biol. - 1996. - Vol. 22. - P. 193-201.
  18. Hynynen K., Jolesz F.A. Demonstration of potential noninvasive ultrasound brain therapy through an intact skull //Ultrasound. Med. Biol. - 1998 - Vol. 24. - P. 275-283.
  19. Kawai A., Muschler G.F., Lane J.M. et al. Prosthetic knee replacement after resection of a malignant tumor of the distal part of the femur. Medium to long-term results //J. Bone Jt Surg. - 1998. - Vol. 80A. - P. 636-647.
  20. Li K.Q., Chen W.Z., Zhu H. et al. MRI presentation of malignant bone tumors after high intensity focused ultrasound therapy //Chin. J. Med. Ultrasound. - 2004. - N 1. - P. 23.
  21. Maris H., Balibar S. Negative pressures and cavitation in liquid helium //Physics Today. - 2000. - Vol. 53. - P. 29-32.
  22. Natarjan M.V., Mohanlal P., Bose J.C. Limb Salvage surgery complimented by customized mega prostheses for malignant fibrous histiocytomas of bone //J. Orthop. Surg. - 2007. - Vol. 15, N 3. - P. 352-356.
  23. Oosterhof G., Cornel E.B., Smits G.A. et al. Influence of high-intensity focused ultrasound on the development of metastases //Eur. Urol. - 1997. - Vol. 32. - P. 91-95.
  24. Orlic D., Smerdelj M., Kolundzic R. et al. Lower limb salvage surgery: modular endoptosthesis in bone tumor treatment //Int. Orthop. - 2006. - Vol. 30, N 6. - P. 458-464.
  25. Rivens B.H., Rowland I.J., Denbow M. et al. Vascular occlusion using focused ultrasound surgery for use in fetal medicine //Eur. J. Ultrasound. - 1999. - N 9. - P. 89-97.
  26. Smith N.B., Temkin J.M., Shapiro F. et al. Thermal effects of focused ultrasound energy on bone tissue //Ultrasound. Med. Biol. - 2001. - Vol. 27. - P. 1427-1433.
  27. Thuroff S., Chaussy C., Vallancien G. et al. High-intensity focused ultrasound and localized prostate cancer: efficacy results from the European multicentric study //J. Endourol. - 2003. - Vol. 17. - P. 673-677.
  28. Vaezy S., Martin R., Kaczkowska P. et al. Use of high-intensity focused ultrasound to control bleeding //J. Vase Surg. -1999. - Vol. 29. - P. 533-542.
  29. Vaughan M., ter Haar G., Hill C.R. et al. Minimally invasive cancer surgery using focused ultrasound: a pre-clinical, normal tissue study //Br. J. Radiol. - 1994. - Vol. 67. - P. 267-274.
  30. Wang W., Chen W.Z., Zhou J.M. et al. Evaluation of high intensity focused ultrasound in the treatment of bone tumor using scintigraphy and MRI //Chin. J. Med. Ultrasound. - 2004. - N 1. - P. 22.
  31. Wu F., Chen W.Z., Bai J. et al. Tumor vessel destruction resulting from high-intensity focused ultrasound in patients with solid malignancies //Ultrasound. Med. Biol. - 2002. - Vol. 28. - P. 535-542.
  32. Wu F., Wang Z.B., Chen W.Z. et al. Advanced hepatocellular carcinoma: treatment with high intensity focused ultrasound ablation combined with transcatheter arterial embolization //Radiology. - 2005. - N 235. - P. 659-667.
  33. Wu F., Wang Z.B., Chen W.Z. et al. Circulating tumor cells with solid malignancy treated by high-intensive focused ultrasound //Ultrasound. Med. Biol. - 2004. - Vol. 30. - P. 1217-1222.
  34. Wu F., Wang Z.B., Chen W.Z. et al. Extracorporeal focused ultrasound surgery for treatment of human solid carcinomas: early Chinese clinical experience //Ultrasound. Med. Biol. - 2004. - Vol. 30. - P. 245-260.
  35. Wu F., Wang Z.B., Chen W.Z. et al. Extracorporeal high intensity focused ultrasound ablation in the treatment of patients with large hepatocellular carcinoma //Ann. Surg. Oncol. - 2004. - Vol. 11. - P. 1061-1069.
  36. Wu F., Wang Z.B., Chen W.Z. et al. Preliminary experience using high intensity focused ultrasound for the treatment of patients with advanced stage renal malignancy //J. Urol. - 2003. - Vol. 170. - P. 2237-2240.
  37. Wu F., Wang Z.B., Zhu H. et al. Extracorporeal high intensity focused ultrasound treatment for patients with breast cancer //Breast Cancer Res. - 2005. - Vol. 92. - P. 51-60.
  38. Yang G.R., Li M., Li G.L. et al. The nuclide imaging of primary malignant bone tumor before and after HIFU treatment //Chin. J. Nucl. Med. - 2002. - Vol. 22. - P. 294-295.
  39. Zeng Y., Luo X.P., Gan W. et al. Malignant bone tumors post combined therapy of HIFU and intervention: a preliminary study on the imaging findings //J. Clin. Radiol. - 2000. - Vol. 19. - P. 444-447.
  40. Zeng Y., Luo X.P., Yu M.X. et al. Angiographic changes of malignant bone tumors after combined treatment of intra-arterial infusion and HIFU //J. Chongqing Med. University. - 2000. - Vol. 25. - P. 411-413.
  41. Zou J.Z., Chen W.Z., Liao C.R. et al. Ultrasonography of osteosarcoma therapy by high intensity focused ultrasound //Chin. J. Ultrason. - 2000. - Vol. 9. - P. 695-696.



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