Anti-gout and Urate-lowering Potentials of Curcumin: A Review from Bench to Beside


Дәйексөз келтіру

Толық мәтін

Аннотация

Background:Gouty arthritis is a complex form of inflammatory arthritis, triggered by the sedimentation of monosodium urate crystals in periarticular tissues, synovial joints, and other sites in the body. Curcumin is a natural polyphenol compound, isolated from the rhizome of the plant Curcuma longa, possessing countless physiological features, including antioxidant, anti-inflammatory, and anti-rheumatic qualities.

Objective:This study aimed to discuss the beneficial impacts of curcumin and its mechanism in treating gout disease.

Methods:Ten English and Persian databases were used to conduct a thorough literature search. Studies examining the anti-gouty arthritis effects of curcumin and meeting the inclusion criteria were included.

Results:According to the studies, curcumin has shown xanthine oxidase and urate transporter- 1 inhibitory properties, uric acid inhibitory characteristics, and antioxidant and anti- inflammatory effects. However, some articles found no prominent reduction in uric acid levels.

Conclusion:In this review, we emphasized the potency of curcumin and its compounds against gouty arthritis. Despite the potency, we suggest an additional well-designed evaluation of curcumin, before its therapeutic effectiveness is completely approved as an antigouty arthritis agent.

Негізгі сөздер

Авторлар туралы

Amir Jafari-Nozad

Student Research Committee, Birjand University of Medical Sciences

Email: info@benthamscience.net

Amirsajad Jafari

Department of Basic Sciences, School of Veterinary Medicine, Shiraz University,

Email: info@benthamscience.net

Saman Yousefi

Faculty of Veterinary Medicine,, Shahrekord Branch, Islamic Azad University,

Email: info@benthamscience.net

Hasan Bakhshi

Vector-borne Diseases Research Center,, North Khorasan University of Medical Sciences

Email: info@benthamscience.net

Tahereh Farkhondeh

Department of Toxicology and Pharmacology, School of Pharmacy, Birjand University of Medical Sciences

Хат алмасуға жауапты Автор.
Email: info@benthamscience.net

Saeed Samarghandian

Healthy Ageing Research Centre, Neyshabur University of Medical Sciences

Хат алмасуға жауапты Автор.
Email: info@benthamscience.net

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