POLYMORPHISM OF INTERLEUKIN GENE-1 (IL-1β) IN PATIENTS WITH MULTIPLE SCLEROSIS



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Abstract

There were examined 60 patients with remitting type of multiple sclerosis. Genotyping had been performed with the help of PCR by a polymorphic variant +3953 А1/А2 gene IL-1в. It was found that polymorphism IL-1в +3953 A1/A2 is not the leading factor in a susceptibility to multiple sclerosis and does not define the disease phenotype. At the same time presence of some or other allele can contribute into misbalance between proinflammatory and anti-inflammatory cytokines.

About the authors

Valentina М Аlifirova

Siberian State Medical University

Email: nerv@ssmu.tomsk.ru
кафедра неврологии и нейрохирургии; Сибирский государственный медицинский университет; Siberian State Medical University

Yulia Yu Оrlova

Siberian State Medical University

Email: nerv@ssmu.tomsk.ru
кафедра неврологии и нейрохирургии; Сибирский государственный медицинский университет; Siberian State Medical University

Мarina А Тitova

Siberian State Medical University

Email: nerv@ssmu.tomsk.ru
кафедра неврологии и нейрохирургии; Сибирский государственный медицинский университет; Siberian State Medical University

Nadejda V Cherdyntseva

Cancer Research Institute of Tomsk Scientific Centre of the Russian Academy of Medical Sciences

Email: nii@oncology.tomsk.ru
Cancer Research Institute of Tomsk Scientific Centre of the Russian Academy of Medical Sciences

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Copyright (c) 2010 Аlifirova V.М., Оrlova Y.Y., Тitova М.А., Cherdyntseva N.V.

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