ULTRASTRUCTURAL CHANGES IN AXON-DENDRITIC SYNAPSES OF CA1 OF HIPPOCAMPUS UNDER 96-HOUR PARADOXIAL SLEEP DEPRIVATION



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Abstract

With the application of electron microscope technique the morphology of axon-dendritic synapses in area CA1 of rat hippocampus under 96-hour paradoxical sleep deprivation has been studied. On the basis of quantitative and qualitative-morphometric analysis it has been stated that the ultrastructure of the components of most symmetrical and asymmetrical axon-dendritic synapses were deeply affected in response to the 96-hour paradoxical sleep deprivation. The revealed ultrastructural alterations in axon-dendritic synapses of CA1 area can be considered as synaptic level of disturbances of neurophysiological mechanisms of learning and memory processes.

About the authors

Babek M Abushov

A.I. Karajev Physiology Institute of NAS

Email: babushov@rambler.ru
Лаборатория функциональной цитохимии; Институт физиологии им. А.И. Караева НАН; A.I. Karajev Physiology Institute of NAS

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