Clinical observation of cerebral venous thrombosis and reversible vasoconstriction syndrome in a young patient

Cover Page


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Despite the capabilities and availability of modern diagnostic methods, due to the low alertness of doctors, a number of cerebrovascular disorders are diagnosed late, which can lead to serious consequences, illness leading to disability and death in patients of working age.

A clinical case of a young patient with recurrent cerebral venous thrombosis and reversible cerebral vasoconstriction syndrome is presented.

Full Text

Restricted Access

About the authors

Elena G. Klocheva

North-Western State Medical University named after I.I. Mechnikov

Email: klocheva@mail.ru
ORCID iD: 0000-0001-6814-0454
SPIN-code: 6220-5349

MD, Dr. Sci. (Med.), Prof., Depart. of Neurology named after acad. S.N. Davidenkov

Russian Federation, St. Petersburg

Vitalii V. Goldobin

North-Western State Medical University named after I.I. Mechnikov

Email: Goldobin@szgmu.ru
ORCID iD: 0000-0001-9245-8067
SPIN-code: 4344-5782

MD, Dr. Sci. (Med.), Prof., Head of Depart., Depart. of Neurology named after acad. S.N. Davidenkov

Russian Federation, St. Petersburg

Farakhnoz Z. Olimova

North-Western State Medical University named after I.I. Mechnikov

Author for correspondence.
Email: farahnoz.zafarovna1994@gmail.com
ORCID iD: 0000-0003-2239-0073
SPIN-code: 5339-9323

MD, Cand. Sci. (Med.), Neurologist, Depart. No. 2 (12-3), Neurology Clinic named after S.N. Davidenkov

Russian Federation, St. Petersburg

Valentina N. Semich

North-Western State Medical University named after I.I. Mechnikov

Email: semich@mail.ru

MD, Cand. Sci. (Med.), Radiologist, Doctor of the Highest Category

Russian Federation, St. Petersburg

Marina Yu. Afanasyeva

North-Western State Medical University named after I.I. Mechnikov

Email: m.y.afanaseva@mail.ru
ORCID iD: 0000-0002-1726-7380
SPIN-code: 6115-0296

MD, Cand. Sci. (Med.), Assistant, Neurologist, Head of Depart., Depart. No. 2 (12-3), Neurology Clinic named after S.N. Davidenkov

Russian Federation, St. Petersburg

Mariya V. Zhukova

North-Western State Medical University named after I.I. Mechnikov

Email: M-a-r-i-e-l-a@mail.ru
ORCID iD: 0009-0008-8653-632X
SPIN-code: 7561-5322

MD, Cand. Sci. (Med.), Assistant, Neurologist, Depart. No. 2 (12-3), Neurology Clinic named after S.N. Davidenkov

Russian Federation, St. Petersburg

Farangis Z. Olimova

Avicenna Tajik Medical University

Email: farangis_-z@mail.ru
SPIN-code: 5206-0441

MD, Cand. Sci. (Med.), Assoc. Prof., Depart. of Obstetrics and Gynecology No. 1

Tajikistan, Dushanbe

Muhiddi S. Partavi

Hospital for war veterans

Email: partavi.muhiddin@mail.ru
ORCID iD: 0000-0002-7358-9691
SPIN-code: 1518-3503

MD, Cand. Sci. (Med.), Cardiologist

Russian Federation, St. Petersburg

References

  1. Cavalcanti DD, Raz E, Shapiro M, et al. Cerebral venous thrombosis associated with COVID-19. AJNR Am J Neuroradiol. 2020;41(8):1370–1376. doi: 10.3174/ajnr.A6644
  2. Takasu S, Ariizumi M, Matsumoto S, et al. Cerebral venous sinus thrombosis associated with COVID-19: An autopsy case report. Forensic Sci Med Pathol. 2022;18:80–85. doi: 10.1007/s12024-022-00458-5
  3. Ferro JM, Aguiar de Sousa D. Cerebral venous thrombosis: An update. Current Neurology and Neuroscience Reports. 2019;19(74): 1–9.
  4. Ramazanov GR, Korigova KhV, Petrikov SS. Diagnostika i lechenie tserebral'nogo venoznogo tromboza. Russian Sklifosovsky Journal of Emergency Medical Care. 2021;10(1):122–134. (In Russ.) doi: 10.23934/2223-9022-2021-10-1-122-134
  5. Ulivi L, Squitieri M, Cohen H, et al. Cerebral venous thrombosis: A practical guide. Practical Neurology. 2020;20(5):356–367. doi: 10.1136/practneurol-2019-002415
  6. Maksimova MYu, Dubovitskaya YuI, Bryukhov VV, Krotenkova MV. Diagnosis of cerebral veins and venous sinuses thrombosis. RMJ. 2017;(21):1595–1601. (In Russ.)
  7. Lu SR, Liao YC, Lirng JF, Wang SJ. Nimodipine for treatment of primary thunderclap headache. Neurology. 2004;62:1414–1416.
  8. Duman T, Uluduz D, Midi I, et al. A multicenter study of 1144 patients with cerebral venous thrombosis: the VENOST study. Journal of Stroke and Cerebrovascular Diseases. 2017;26(8):1848–1857. doi: 10.1016/j.jstrokecerebrovasdis.2017.04.020
  9. Krivopalov AA, Shcherbuk AYu, Shcherbuk YuA, et al. Cerebral venous thrombosis in otorhinolaryngology. Consilium Medicum. 2022;24(9):632–636. (In Russ.) doi: 10.26442/20751753.2022.9.201910
  10. Caso V, Agnelli G, Paciaroni M. Handbook on Cerebral Venous Thrombosis. Karger Medical and Scientific Publishers. 2008;23:96–111.
  11. Zhuravkov JuL, Koroleva AA, Stanishevskij AL. Sovremennye podhody k diagnostike i lecheniju tserebral'nyh venoznyh trombozov. Voennaja meditsina. 2012;3(24):133–141. (In Russ.)
  12. Trofimova TN, Ternovoj SK, Anan'eva NI, Semenova SE. Luchevaja diagnostika i terapija zabolevanij golovy i shei. Rukovodstvo dlja vrachej. Natsional'noe rukovodstvo. TN Trofimov ed. Moscow: GEOTAR Media; 2013. р. 279–288. (In Russ.)
  13. Van Dam LF, van Walderveen MA, Kroft LJ, et al. Current imaging modalities for diagnosing cerebral vein thrombosis — A critical review. Thrombosis Research. 2020;189:132–139. doi: 10.1016/j.thromres.2020.03.011
  14. Stam J. Thrombosis of the cerebral veins and sinuses. New England Journal of Medicine. 2005;352:1791–1798. doi: 10.1056/NEJMra042354
  15. Canedo-Antelo M, Baleato-González S, Mosqueira AJ. Radiologic clues to cerebral venous thrombosis. Radiographics. 2019;39(6):1611–1628. doi: 10.1148/rg.2019190015
  16. Kulesh АА. Cerebral venous thrombosis and its hemorrhagic complications. Nevrologiya, neiropsikhiatriya, psikhosomatika. 2021;13(2):10–18. (In Russ.) doi: 10.14412/2074-2711-2021-2-10-18
  17. Ferro JM, Bousser M-G, Canhão P, et al. European Stroke Organization guideline for the diagnosis and treatment of cerebral venous thrombosis — Endorsed by the European Academy of Neurology. European Stroke Journal. 2017;2(3):195–221. doi: 10.1177/2396987317719364
  18. Afanas'eva MJu, Goldobin VV, Klocheva EG. Klinicheskie projavlenija, faktory riska i tserebral'nye angiodisplazii pri sindrome obratimoj tserebral'noj vazokonstriktsii. Meditsinskij alfavit. 2020;(22):22–26. (In Russ.) doi: 10.33667/2078-5631-2020-22-22-26
  19. Chen SP, Fuh JL, Wang SJ, et al. Brain-derived neurotrophic factor gene Val66Met polymorphism modulates reversible cerebral vasoconstriction syndromes. PLoS One. 2011;6:e18024.
  20. Ayroyan AG, Shumilina MV. Headaches of vascular origin. Klinicheskaya Fiziologiya Krovoobrashcheniya. 2017;14(2):65–73 (In Russ.) doi: 10.24022/1814-6910-2017-14-2-65-73
  21. Ducros A. Reversible cerebral vasoconstriction syndrome. Lancet Neurol. 2012;11:906–917.
  22. Palma JA, Fontes Villalba A, Irimia P, et al. Reversible cerebral vasoconstriction syndrome induced by adrenaline. Cephalalgia. 2012;32:500. doi: 10.1016/S1474-4422(12)70135-7
  23. Singhal AB, Hajj-Ali RA, Topcuoglu MA, et al. Reversible cerebral vasoconstriction syndrome: analysis of 139 of cases. Arch Neurol. 2011;68:1005–1012.
  24. Topcuoglu MA, Kursun O, Singhal AB. Coexisting vascular lesions in reversible cerebral vasocon — striction syndrome. Cephalalgia. 2017;37:29.
  25. Hiraga A, Aotsuka Y, Koide K, Kuwabara S. Reversible cerebral vasoconstriction syndrome precipitated by airplane descent: Case report. Cephalalgia. 2017;37:1102. doi: 10.1177/0333102416637826
  26. Calic Z, Choong H, Schlaphoff G, Cappelen-Smith C. Reversible cerebral vasoconstriction syndrome following indomethacin. Cephalalgia. 2014;34:1181. doi: 10.1177/0333102414530526
  27. Ducros A, Boukobza M, Porcher R, et al. The clinical and radiological spectrum of reversible cerebral vasoconstriction syndrome. A prospective series of 67 patients. Brain. 2007;130(12):3091–3101. doi: 10.1093
  28. Marra A, Vargas M, Striano P, et al. Posterior reversible encephalopathy syndrome: The endothelial hypotheses. Med Hypotheses. 2014;82:619–622.
  29. Klocheva EG, Goldobin VV. Diagnostika sindroma obratimoj tserebral'noj vazokonstriktsii: klinicheskie projavlenija i dannye metodov luchevoj diagnostiki. Luchevaja diagnostika i terapija. 2018;3:50–55. (In Russ.)
  30. Chen SP, Wang SJ. Hyperintense vessels: An early MRI marker of reversible cerebral vasoconstriction syndrome? Cephalalgia. 2014;34:1038–1039. doi: 10.1177/0333102414529193
  31. Manysheva KB. Gendernye osobennosti ostryh narushenij mozgovogo krovoobraschenija. Meditsinskij alfavit. 2018;1(1):45–49. (In Russ.)
  32. Belova LA, Mashin VV, Sitnikova AI, Belov DV. Sovremennye predstavlenija o faktorah riska tserebral'nyh venoznyh trombozov. Ul'janovskij mediko-biologicheskij zhurnal. 2020;(3):8–20. (In Russ.)
  33. Klocheva YG, Olimova FZ, Goldobin VV, Bogatenkova JD. Demielinizirujuschee zabolevanie u patsientki s tserebral'nym venoznym trombozom na fone manifestnoy novoy koronavirusnoj infeksii. Neurology Bulletin. 2022;LIV(2):85–95. (In Russ.) doi: 10.17816/nb104446
  34. Baldini T, Asioli GM, Romoli M, et al. Cerebral venous thrombosis and SARS-CoV-2 infection: a systematic review and meta-analysis. Eur J Neurol. 2021;31(5):2956–2966. doi: 10.1111/ene.14727
  35. Saposnik G, Barinagarrementeria F, Brown RD Jr, et al. Diagnosis and management of cerebral venous thrombosis: A statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42(4):1158–1192. doi: 10.1161/ STR.0b013e31820a8364
  36. Coutinho JM, de Bruijn SF, deVeber G, Stam J. Anticoagulation for cerebral venous sinus thrombosis. Stroke. 2012;43(4):e41–e42. doi: 10.1161/strokeaha.111.648162
  37. Kearon C, Akl EA, Ornelas J, et al. Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report. Chest. 2016;149(2):315–352. doi: 10.1016/j.chest.2015.11.026
  38. Ortel TL, Neumann I, Ageno W, et al. American Society of Hematology 2020 guidelines for management of venous thromboembolism: treatment of deep vein thrombosis and pulmonary embolism. Blood advances. 2020;4(19):4693–4738. doi: 10.1182/bloodadvances.2020001830
  39. Mahale R, Mehta A, John AA. Acute seizures in cerebral venous sinus thrombosis: What predicts it? Epilepsy Research. 2016;123:1–5. doi: 10.1016/j.eplepsyres.2016.01.011
  40. Tabaei S, Omraninava M, Mehranfar S, et al. Plasminogen activator inhibitor-1 polymorphisms and risk of coronary artery disease: Evidence from meta-analysis and trial sequential analysis. Biochem Genet. 2022;60:1409–1445. doi: 10.1007/s10528-021-10143-x
  41. Haneen AT, Zeina A, Louay AA. Genetic study of ITGA2 polymorphisms and impact on diabetic retinopathy risk in Al-Anbar population. Archivos Venezolanos de Farmacologia y Terapéutica. 2021;40(5):469–476.
  42. Musashaykhov UK, Karimov KYa, Musashaykhov KT, Boboev KT. Analysis of the role of the C807T polymorphism of the ITGA2 gene with the development of vascular thromboses of different localizations. British Medical Journal. 2021;1(1.2):88–99.
  43. Lugacheva JuG, Suslova TE, Kulagina IV, et al. Polimorfizm genov folatnogo obmena i tromboticheskie oslozhnenija u patsientov s funktsional'no edinstvennym zheludochkom serdtsa. Sibirskij zhurnal klinicheskoj i `eksperimental'noj meditsiny. 2021;36(4):86–91. (In Russ).
  44. Smulska N, Rossokha Z, Fishchuk L, et al. Polymorphisms variants of the MTHFR C677T and PAI-1 5G/4G genes and their combinations in the group of children with arterial ischemic stroke. Neurologia Dziecięca. 2020;29(58):27–32. doi: 10.20966/chn.2020.58.455
  45. Wang J, Sun Z, Yang Y, et al. Association of laboratory parameters and genetic polymorphisms with ischemic stroke in Chinese Han population. Experimental and Therapeutic Medicine. 2021;21(5):1–9.
  46. Afanas'eva MJu. Klinicheskie i diagnosticheskie osobennosti sindroma obratimoj tserebral'noj vazokonstriktsii. Dis. … kand. nevrol. nauk: 3.1.24. SPb.; 2023. 121 р. (In Russ.)
  47. Ferro JM, Bousser MG, Canhão P, et al. European Stroke Organization guideline for the diagnosis and treatment of cerebral venous thrombosis — endorsed by the European Academy of Neurology. European Stroke Journal. 2017;2(3):195–221.
  48. Yaghi S, Shu L, Bakradze E, et al. Direct oral anticoagulants versus warfarin in the treatment of cerebral venous thrombosis (ACTION-CVT): A multicenter international study. Stroke. 2022;29(2):728–738.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download
2. Fig. 1. Magnetic resonance imaging of the brain (October 27, 2020). Magnetic resonance image (FLAIR pulse sequence) of acute venous infarction in the right parietal lobe (a) with signs of thrombosis of the superior sagittal (c, d), transverse (b) and partially sigmoid sinuses on the right (b).

Download (334KB)
Indexing metadata
3. Fig. 2. Magnetic resonance (MR) tomogram of the brain and MR venosinusography (November 22, 2020). MRI picture (FLAIR and SWI pulse sequences) of an intracerebral hematoma of the right parietal lobe in the late subacute-chronic stage (consequences of venous infarction) (a, b) with signs of recanalization of the superior sagittal sinus (d, blue arrow), partially right transverse (d, black arrow) and sigmoid (c, d, green arrows) sinuses, right internal jugular vein of varying degrees (d, red arrow).

Download (320KB)
Indexing metadata
4. Fig. 3. Magnetic resonance venosinusogram (July 24, 2022). Signs of repeated thrombosis of the right transverse and sigmoid (a, b) sinuses and slowing of blood flow in the internal jugular vein on the right (c).

Download (240KB)
Indexing metadata
5. Fig. 4. Magnetic resonance angiogram (17.10.2023). A variant of the development of the circle of Willis with the formation of a complete left-sided posterior trifurcation. The arrows indicate short areas of segmental spasm of the intracranial arteries (probably reversible cerebral vasoconstriction syndrome).

Download (111KB)
Indexing metadata
6. Fig. 5. Magnetic resonance venosinusogram (17.10.2023). Compared to 2022, there is a positive trend in the form of restoration of blood flow through the right sigmoid and partially transverse sinuses and the right internal jugular vein.

Download (228KB)
Indexing metadata

Copyright (c) 2024 Eco-Vector


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 75562 от 12 апреля 2019 года.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies