GLYCINE IMPORTANCE IN ACUTE ISCHEMIC STROKE THERAPY
- Authors: Nartsissov Y.R1, Sheshegova E.V1, Mashkovtseva E.V1, Maksimova L.N1
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Affiliations:
- Institute of Cytochemistry and Molecular Pharmacology
- Issue: Vol XLVII, No 1 (2015)
- Pages: 85-90
- Section: Articles
- URL: https://journals.eco-vector.com/1027-4898/article/view/13927
- DOI: https://doi.org/10.17816/nb13927
- ID: 13927
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Abstract
There was shown the prevalence of vascular diseases, including acute cerebrovascular events, reasons of such disorders being multiple systemic changes of neuron metabolism. The correction of imbalance of excitatory and inhibitory neurotransmitter systems is one of the most promising methods of neuroprotection. Much attention is paid to the role of an inhibitory neurotransmitter glycine in the mechanisms of acute cerebral ischemia. Positive effects of glycine on neuronal mitochondrial metabolism have been observed under hypoxic (anoxic) conditions. It was also shown a reduction of events which had been induced by glutamate concentration excess. Along with the effect of direct vasodilation of glycine on arterioles of different tissues it enables to consider glycine as a neuroprotective compound i.e. the medicines which protect against ischemic cascade in therapeutic window.
Keywords
About the authors
Yaroslav R Nartsissov
Institute of Cytochemistry and Molecular Pharmacology115404, Moscow, 6th Radialnaya str., 24/14
Elena V Sheshegova
Institute of Cytochemistry and Molecular Pharmacology115404, Moscow, 6th Radialnaya str., 24/14
Elena V Mashkovtseva
Institute of Cytochemistry and Molecular Pharmacology115404, Moscow, 6th Radialnaya str., 24/14
Lyudmila N Maksimova
Institute of Cytochemistry and Molecular Pharmacology
Email: ludamaksimova@mail.ru
115404, Moscow, 6th Radialnaya str., 24/14
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