The comparative phytochemical and microbiological study of liquid extracts based on the fruits of the Crataegus sanguinea Pall. and Crataegus submollis Sarg


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Abstract

The preparations based on hawthorn fruits have cardiotonic action. One of the reasons of chronic cardiovascular pathology are various inflammatory processes in the human body. In this regard it is actual the study the antimicrobial activity of preparations based on the raw materials of various species of the Hawthorn genus (Crataegus L.) among which hawthorn blood-red and Quebec hawthorn are promising. Hawthorn blood-red (Crataegus sanguinea Pall.) is a wild-growing plant which is wide-spread in the territory of our country. Quebec hawthorn (Crataegus submollis Sarg.) is widely cultivated on the territory of the Russian Federation and it is characterized by rapid growth and high yield. Liquid extracts were obtained based on the fruits of two species of hawthorn in a ratio of 1:1 using 70% ethyl alcohol. The determination of the minimal inhibiting concentration was carried out by double serial dilution in broth. As test cultures, we used the following microorganisms: Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Bacillus cereus, Candida albicans. The study of antimicrobial activity against several microorganisms made it possible to reveal the moderate antimicrobial activity of liquid extracts based on the fruits of hawthorn blood-red and Quebec hawthorn. In addition to the above the antifungal activity of the extract based on hawthorn blood-red fruits is more expressed.

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About the authors

V. A Kurkin

Samara State Medical University

Email: Kurkinvladimir@yandex.ru
Dr.Sc. (Pharm.), Head of the Pharmacognosy Department

T. V Morozova

Samara State Medical University

Post-graduate Student, Pharmacognosy Department

I. K Shaikhutdinov

Samara State Medical University

Post-graduate Student, Pharmacognosy Department

A. V Lyamin

Samara State Medical University

Ph.D. (Med.), Associate Professor, Department of General and Clinical Microbiology, Immunology and Allergology

O. E Pravdivtseva

Samara State Medical University

Dr.Sc. (Pharm.), Associate Professor, Pharmacognosy Department

S. V Pervushkin

Samara State Medical University

Dr.Sc. (Pharm.), Head of the Department of Pharmaceutical Technology

A. A Kretova

Samara State Medical University

Student, Pharmaceutical Faculty

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