Effect of Orostachys spinosa dry extract on white rat behavior in tests with positive reinforcement
- Authors: Razuvaeva Y.G.1, Bayanduyeva Y.A.1, Toropova A.A.1, Nikolaeva I.G.1
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Affiliations:
- Institute of General and Experimental Biology, Siberian Branch of the Russian Academy of Sciences
- Issue: Vol 14, No 2 (2023)
- Pages: 149-155
- Section: Phytopharmacology
- URL: https://journals.eco-vector.com/1606-8181/article/view/501755
- DOI: https://doi.org/10.17816/phbn501755
- ID: 501755
Cite item
Abstract
BACKGROUND: Mining grate prickly (Orostachys spinosa (L.) Sweet) is a perennial herb of the Crassulaceae family that is widely used in folk medicine fresh as a decoction for epilepsy and sedative for nervous disorders.
AIM: To examine the effect of O. spinosa dry extract on the white rat behavior in tests with positive reinforcement.
MATERIALS AND METHODS: Experiments were conducted on 82 Wistar rats. The O. spinosa dry extract effects at doses of 50, 100, and 200 mg/kg on animal behavior were assessed in the hypophagy and T-maze tests.
RESULTS: Following the introduction of O. spinosa extract at doses of 100 and 200 mg/kg, the number of animals fed in the hypophagy test was 1.6 and 1.8 times greater than that in the control, and the feed volume exceeded by 94% and 78%, respectively, the indicator in the control group. On day 4 of training, a conditioned reflex was observed in 100% of the animals treated with 200 mg/kg O. spinosa extract. Following the administration of the O. spinosa extract at a dose of 100 mg/kg and the reference drug, a conditioned reflex was observed in 63% and 71% of the animals, respectively, which was 2.0 times higher than that in the control group.
CONCLUSION: The 100 and 200 mg/kg O. spinosa dry extracts positively affected the removal of the anxiety level, promoted an increase in orienting–exploratory activity, and thereby accelerated the development of a conditioned reflex in white rats.
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About the authors
Yanina G. Razuvaeva
Institute of General and Experimental Biology, Siberian Branch of the Russian Academy of Sciences
Author for correspondence.
Email: tatur75@mail.ru
ORCID iD: 0000-0001-7829-1424
SPIN-code: 8338-9336
Dr. Sci. (Biol.), senior researcher
Russian Federation, 6, Sakhyanovoi str., Ulan-Ude, 670047Yelena A. Bayanduyeva
Institute of General and Experimental Biology, Siberian Branch of the Russian Academy of Sciences
Email: baynduev@mail.ru
ORCID iD: 0009-0009-4748-0068
post-graduate studenthttp
Russian Federation, 6, Sakhyanovoi str., Ulan-Ude, 670047Anyuta A. Toropova
Institute of General and Experimental Biology, Siberian Branch of the Russian Academy of Sciences
Email: anyuta-tor@mail.ru
ORCID iD: 0000-0003-2618-7777
SPIN-code: 4457-1872
Cand. Sci. (Biol.), senior researcher
Russian Federation, 6, Sakhyanovoi str., Ulan-Ude, 670047Irina G. Nikolaeva
Institute of General and Experimental Biology, Siberian Branch of the Russian Academy of Sciences
Email: i-nik@mail.ru
ORCID iD: 0000-0002-3476-1014
SPIN-code: 8001-5544
Dr. Sci. (Pharmacy), associate professor, senior researcher
Russian Federation, 6, Sakhyanovoi str., Ulan-Ude, 670047References
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