Psychopharmacological Profile of Nootropic-like Peptides

Shabanov PD, Lebedev AA, Kornilov VA, Lavrov NV, Lyubimov AV, Yaklashkin AV. [Psychopharmacological Profile of Nootropic-like Peptides]. Psychopharmacol Biol Narcol. 2009; 9(1-2). Epub 2009 May 04. Russian.
The analysis of phychopharmacological profile of 9 peptide drugs (cortexin, cerebrolysine, deltaran, cortagen, oleyl-cortagen, semax, selank, noopept, dilept) in comparison with piracetam and mexidol was shown that cerebrolysine (1 mg/kg), oleyl-cortagen (1 mg/kg) and piracetam (200 mg/kg) pos-sessed activating effect on motor and research components of behavior in "open field" test, and piracetam and cerebrolysine increased the emotional status of rats. Deprimating type of action was revealed in dilept (1 mg/kg), which decreased horizontal and vertical motor activity in rats. Only one peptide, selank (0.1 mg/kg), possessed antiaggresion action. A number of peptides (oleyl-cortagen, dilept and cortexin) demonstrated antidepressant effects, while cerebrolysine (1 mg/kg), oleyl-cortagen (1 mg/kg) and selank (0.1 mg/kg), on the other hand, performed depressant action on rat behavior in the Porsolt' test. Therefore, the significant psychoactivating properties are typical for cerebrolysine, oleyl-cortagen, cortexin and piracetam, while dilept, selank and in the less degree semax inhibited rat behavior, demonstrating deprimating type of action. [in Russian with English Summary].
Citation: Psychopharmacol Biol Narcol. 2009; 9 (1-2): 2517-2523

phychopharmacological profile, peptides, cortexin, cerebrolysine, deltaran, cortagen, oleyl-cortagen, semax, selank, noopept, dilept