The study of beta-glucan immunomodulating effect in the organotypic culture of rat immune tissue
- Authors: Chalisova N.I.1,2, Ryzhak G.A.2, Arzhavkina L.G.3, Mutzina E.V.3
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Affiliations:
- Pavlov Institute of Physiology RAS
- Saint Petersburg Institute of Bioregulation and Gerontology investigation
- Federal State Budgetary Military Educational Institution of Higher Education “Military Medical Academy named after S.M. Kirov” of the Ministry of Defense of the Russian Federation
- Issue: Vol 22, No 4 (2024)
- Pages: 28-31
- Section: Original research
- URL: https://journals.eco-vector.com/1728-2918/article/view/635023
- DOI: https://doi.org/10.29296/24999490-2024-04-04
- ID: 635023
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Abstract
Introduction. An urgent problem in biology and medicine is the identification of biologically active molecules that affect the cellular processes of proliferation and apoptosis in various tissues of the body.
Purpose of the study. The purpose of this study was to identify the effect of combinations of immunomodulating beta-glucan with immunodepresive preparation cycklophosphamide in organotypic immune tissue of kidney and thymus of 5-months rats.
Material and methods. The method of organotypic cultivation of immune tissues of kidney and thymus was used for rapid screening of the biological activity of the studied beta-glucan.
Results. It has been established that by the combined use of beta-glucan and cycklophosphamide the immunodepresive effect is eliminated.
Conclusion. The data obtained create the basis for beta-glucan usage as a protector by the immunodepresive action of different substances. The base is created for creation of new drugs for treatment of the oncological and infection deseases.
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About the authors
Natalia I. Chalisova
Pavlov Institute of Physiology RAS; Saint Petersburg Institute of Bioregulation and Gerontology investigation
Author for correspondence.
Email: ni_chalisova@mail.ru
ORCID iD: 0000-0002-2371-0043
Expert scientific worker of the I.P. Pavlov Institute of Physiology RAS; Expert scientific worker Gerontology in. the laboratory of Oncogerontology of Biogerontology department of Saint Petersburg Institute of Bioregulation and Gerontology Doctor of biology sciences, Professor.
Russian Federation, Emb. Makarova 6, Saint Petersburg, 199034; Dynamo Ave., 3, Saint Petersburg, 197110Galina A. Ryzhak
Saint Petersburg Institute of Bioregulation and Gerontology investigation
Email: galina@gerontology.ru
ORCID iD: 0000-0003-2536-1438
Director of Saint Petersburg Institute of Bioregulation and Gerontology in scientific investigation. Doctor of medical sciences, рrofessor.
Russian Federation, Dynamo Ave., 3, Saint Petersburg, 197110Leila G. Arzhavkina
Federal State Budgetary Military Educational Institution of Higher Education “Military Medical Academy named after S.M. Kirov” of the Ministry of Defense of the Russian Federation
Email: Leila.Arzhavkina@szgmu.ru
ORCID iD: 0000-0001-5198-874X
Senior Researcher of military therapy laboratory, Candidate of biological Sciences
Russian Federation, str. Academician Lebedev, 6, Saint Petersburg, 194044Elena V. Mutzina
Federal State Budgetary Military Educational Institution of Higher Education “Military Medical Academy named after S.M. Kirov” of the Ministry of Defense of the Russian Federation
Email: elenmurzina@mail.ru
ORCID iD: 0000-0001-7052-3665
Senior Researcher of medicine and ecological toxicology, Candidate of biological Sciences
Russian Federation, str. Academician Lebedev, 6, Saint Petersburg, 194044References
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