Рroliferotropic effect of peptides in liver organotypic tissue culture of different age rats
- Authors: Ryzhak G.A.1, Chalisova N.I.1,2
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Affiliations:
- Saint Petersburg Institute of Bioregulation and Gerontology
- Pavlov Institute of Physiology of the Russian Academy of Sciences
- Issue: Vol 23, No 4 (2025)
- Pages: 39-42
- Section: Original research
- URL: https://journals.eco-vector.com/1728-2918/article/view/689123
- DOI: https://doi.org/10.29296/24999490-2025-04-06
- ID: 689123
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Abstract
Introduction. One of the actual task of modern biology and medicine is the creation of bioregulator preparation, which have the proliferotropic effect on the internal organs of organism.
Purpose of study. Study of proliferotropic effect of short peptides and polypeptide complex (PPC) in organotypic culture of liver from young and old rats.
Methods. The adequate method of organotypic cultivation of liver tissue from rats of different age was used for rapid screening the biological activity of peptides.
Results. It has been established that by the action of short peptides and PPC square index of liver explants was increased statistically significant both in young and old rats.
Conclusion. The data obtained by the method of organotypic cultivation creates the basis for the development of new preparations, including gerontological, for treatment of liver pathology.
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About the authors
Galina Anatol’evna Ryzhak
Saint Petersburg Institute of Bioregulation and Gerontology
Author for correspondence.
Email: galina@gerontology.ru
ORCID iD: 0000-0003-2536-1438
Associate Director, Doctor of medical sciences, Рrofessor
Russian Federation, 197110, Ave. Dinamo 3, St. PetersburgNatalia Iosifovna Chalisova
Saint Petersburg Institute of Bioregulation and Gerontology; Pavlov Institute of Physiology of the Russian Academy of Sciences
Email: ni_chalisova@mail.ru
ORCID iD: 0000-0002-2371-0043
Expert scientific worker, Expert scientific worker of the laboratory of Oncogerontology of Biogerontology department, Doctor of biologic sciences, professor
Russian Federation, 197110, Ave. Dinamo 3, St. Petersburg; 199034, nab. Makarova, 6, St. PetersburgReferences
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