Indicators of oxidative stress in adolescents with migraines

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  • Authors: Kostyuchenko Y.R.1, Evert L.S.1,2, Potupchik T.V.3, Morozkina A.E.4, Golubev V.I.4, Gasanova N.G.5
  • Affiliations:
    1. Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences”
    2. Federal State Budgetary Educational Institution of Higher Education “Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky” of the Ministry of Health of the Russian Federation
    3. Khakass State University named after N.F. Katanov of the Ministry of Science and Higher Education of the Russian Federation
    4. Pirogov Russian National Research Medical University
    5. Federal State Budgetary Educational Institution of Higher Education “Dagestan State Medical University”
  • Issue: Vol 23, No 5 (2025)
  • Pages: 49-60
  • Section: Original research
  • URL: https://journals.eco-vector.com/1728-2918/article/view/696247
  • DOI: https://doi.org/10.29296/24999490-2025-05-05
  • ID: 696247

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Abstract

Introduction. To date, there are a number of relevant studies devoted to changes in the LPO-AOP system indicators in adolescents and young adults with migraine. However, specific quantitative data and relationships between LPO-AOP indicators and migraine require further study.

The aim of the study was to evaluate migraine-specific LPO-AOZ indices in adolescents and their associations with age and gender of patients.

Material and methods. The study included 104 adolescents aged 12–17 years (boys and girls), comprising 66 participants with migraine (index group) and 38 without migraine (comparison group). The diagnosis was verified using a standardized screening questionnaire in accordance with the International Classification of Headache Disorders, 3rd edition (ICHD-3), which allowed confirmation of migraine and exclusion of other primary headache disorders. Components of the lipid peroxidation–antioxidant defense (LPO–AOD) system were quantified by spectrophotometric methods. Data were processed in Statistica 12 (TIBCO/StatSoft).

Results. Adolescents with migraine showed higher malondialdehyde (MDA) levels in both plasma and erythrocytes, alongside reduced erythrocyte superoxide dismutase (SOD) activity. Compared with controls, the migraine group contained a larger proportion of participants with elevated plasma and erythrocyte MDA and with diminished erythrocyte antioxidant enzyme activities, particularly SOD and catalase (CAT).

Conclusion. Migraine in adolescents is associated with a higher concentration in plasma and red blood cells of the pro–oxidant component of oxidative stress – MDA and lower activity of the enzymatic link of antioxidant protection – SOD and CAT, which indicates a more pronounced intensity of oxidative stress in this contingent. Given the significant role of the imbalance of the POL-AOР system in the development of oxidative stress, the increase in MDA and decrease in SOD and CAT activity that we have identified can probably be regarded as metabolic markers of the presence and/or risk of migraine. This assumption can be confirmed by further research.

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About the authors

Yulia Rinatovna Kostyuchenko

Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences”

Author for correspondence.
Email: axmeldinova@mail.ru
ORCID iD: 0000-0001-6233-6472

Junior Researcher, Clinical Department of Somatic and Mental Health of Children, a Separate Subdivision – Scientific Research Institute of Medical Problems of the North

Russian Federation, Partizana Zheleznyaka St., 3G, Krasnoyarsk, 660022

Lydia Semenovna Evert

Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences”; Federal State Budgetary Educational Institution of Higher Education “Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky” of the Ministry of Health of the Russian Federation

Email: lidiya_evert@mail.ru
ORCID iD: 0000-0003-0665-7428

Chief Researcher, Clinical Department of Somatic and Mental Health of Children, a Separate Subdivision – Scientific Research Institute of Medical Problems of the North, Professor of the Department of General Professional Disciplines, Medical Institute, Doctor of Medical Sciences

Russian Federation, Partizana Zheleznyaka St., 3G, Krasnoyarsk, 660022; Partizana Zheleznyaka St., 1, Krasnoyarsk, 660022

Tatyana Vitalievna Potupchik

Khakass State University named after N.F. Katanov of the Ministry of Science and Higher Education of the Russian Federation

Email: potupchik_tatyana@mail.ru
ORCID iD: 0000-0003-1133-4447

Associate Professor, Department of Pharmacology and Clinical Pharmacology with a postgraduate course, Candidate of Medical Sciences, Medical Institute

Russian Federation, Lenina Ave., 90, Abakan, 655017

Alena Evgenevna Morozkina

Pirogov Russian National Research Medical University

Email: morozkina20021@mail.ru
ORCID iD: 0009-0005-9084-1245

6th year Student

Russian Federation, Ostrovitianova St., 1, Moscow, 117513

Vladislav Igorevich Golubev

Pirogov Russian National Research Medical University

Email: golubevvlad80@gmail.com
ORCID iD: 0009-0000-1654-0253

6th year Student

Russian Federation, Ostrovitianova St., 1, Moscow, 117513

Nabisat Gasanovna Gasanova

Federal State Budgetary Educational Institution of Higher Education “Dagestan State Medical University”

Email: g.nabisat0548@mail.ru
ORCID iD: 0009-0005-9784-3390

6th year Student

Russian Federation, Lenin Square, 1, Republic of Dagestan, Makhachkala, 367000

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