Outcomes of tuberculosis combined with HIV infection
- 作者: Zorkaltseva E.Y.1, Egorova Y.O.1, Plotnikova Y.K.1, Bazhenova Y.V.1
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隶属关系:
- Irkutsk State Medical Academy of Postgraduate Education – Branch Campus of the Russian Medical Academy of Continuing Professional Education
- 期: 卷 20, 编号 6 (2022)
- 页面: 50-55
- 栏目: Original research
- URL: https://journals.eco-vector.com/1728-2918/article/view/321369
- DOI: https://doi.org/10.29296/24999490-2022-06-08
- ID: 321369
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Introduction. The epidemiological process in tuberculosis is negatively affected by the HIV epidemic, the identification of vulnerable groups in relation to the unfavorable course of tuberculosis in combination with HIV infection will improve approaches to treatment and prevention.
The aim of the study was to determine the outcomes of tuberculosis in HIV-infected patients under dispensary supervision with active tuberculosis, and the results of dispensary observation of clinically cured patients with co-infection.
Method. 187 patients aged 18–60 years with tuberculosis and HIV infection underwent clinical and laboratory, microbiological and radiation studies, statistical processing was carried out using the Microsoft Excel application software package.
Results. HIV-infected patients with clinical treatment of tuberculosis have low rates of CD4+ lymphocytes – (0,315•109±0,02)•109 and a high viral load compared to patients with active tuberculosis. After a year, 16.7% of patients with clinical treatment are removed from the register, 36.0% of patients with active tuberculosis are cured, 28.8% of patients have an exacerbation of the process or interruption of treatment, 11.3% die.
Conclusion. In HIV-infected patients with clinical treatment of tuberculosis, the indicators of CD4+ lymphocytes are lower and the viral load is higher than in patients with active tuberculosis, which indicates insufficient adherence to treatment at the outpatient stage and a high risk of recurrence of tuberculosis. The involvement of patients in working with the Call Center contributes to the formation of adherence to both anti-tuberculosis treatment and antiretroviral therapy and favorable outcomes of the disease.
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作者简介
Elena Zorkaltseva
Irkutsk State Medical Academy of Postgraduate Education – Branch Campus of the Russian Medical Academy of Continuing Professional Education
编辑信件的主要联系方式.
Email: zorkaltsewa@mail.ru
ORCID iD: 0000-0002-9449-7577
Medical Doctor, Professor, Head of the Department of tuberculosis and infection diseases
俄罗斯联邦, Yubileyniy, 100, Irkutsk, 664079Yulia Egorova
Irkutsk State Medical Academy of Postgraduate Education – Branch Campus of the Russian Medical Academy of Continuing Professional Education
Email: ya.yulia-e2013@yandex.ru
ORCID iD: 0000-0002-3117-0016
professors assistant Head of the Department of tuberculosis and infection diseases
俄罗斯联邦, Yubileyniy, 100, Irkutsk, 664079Yulia Plotnikova
Irkutsk State Medical Academy of Postgraduate Education – Branch Campus of the Russian Medical Academy of Continuing Professional Education
Email: plot18@yandex.ru
ORCID iD: 0000-0003-2912-9118
associate professor of the Department of tuberculosis and infection diseases
俄罗斯联邦, Yubileyniy, 100, Irkutsk, 664079Yulia Bazhenova
Irkutsk State Medical Academy of Postgraduate Education – Branch Campus of the Russian Medical Academy of Continuing Professional Education
Email: rg.dr@mail.ru
ORCID iD: 0000-0001-8939-3055
associate professor, Head of the Department of Radiation and Clinical Laboratory Diagnostics
俄罗斯联邦, Yubileyniy, 100, Irkutsk, 664079