A new pathogenetic approach and amethod of erectile dysfunction treatment and prevention - modulated erectile oxygenation of penile cavernous tissue
- Authors: Segal AS1, Pushkar DY.1
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Affiliations:
- Issue: No 5 (2004)
- Pages: 48-52
- Section: Articles
- URL: https://journals.eco-vector.com/1728-2985/article/view/275584
- ID: 275584
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Abstract
The analysis of sexual activity of 185 male Muscovites has revealed
an age-related sharp progressive shortening of adequate and
spontaneous erections. A novel, pathogenetically sound approach and
a method of therapy and prevention of erectile dysfunction has been
developed (RF patent N 2228754). The method, called "Modulated
Erectile Oxygenation of Penile Cavernous Tissue" (MEOPCT), consists
in erection activation by behavioral measures and/or erectogenic
drugs which induce adequate, nocturnal spontaneous and/or artificial
erections adequate in frequency and duration for providing such oxygenation
of cavernous bodies that warrants maintenance of their normal
structure and function. There is no continuous close correlation
between sexual activity and erections, on the one side, and ejaculation
and orgasm, on the otherside. Application of MEOPCT in 43 patients
demonstrated the method ability to improve erection and cavernous
hemodynamics without negative side effects
an age-related sharp progressive shortening of adequate and
spontaneous erections. A novel, pathogenetically sound approach and
a method of therapy and prevention of erectile dysfunction has been
developed (RF patent N 2228754). The method, called "Modulated
Erectile Oxygenation of Penile Cavernous Tissue" (MEOPCT), consists
in erection activation by behavioral measures and/or erectogenic
drugs which induce adequate, nocturnal spontaneous and/or artificial
erections adequate in frequency and duration for providing such oxygenation
of cavernous bodies that warrants maintenance of their normal
structure and function. There is no continuous close correlation
between sexual activity and erections, on the one side, and ejaculation
and orgasm, on the otherside. Application of MEOPCT in 43 patients
demonstrated the method ability to improve erection and cavernous
hemodynamics without negative side effects
References
- Kim N., Vardi Y., Padma-Nathan H. et al. Oxygen tension regulates the nitric oxide pathway. Physiological role in penile erection. J. Clin. Invest. 1993; 91: 437-441.
- Sattar A. A., Salpigides G., Vanderhaeghen J. J. etal. Cavernous oxygen tension and smooth muscle fibers: relation and function.J. Urol. (Baltimore) 1995; 154: 1736-1739.
- Stief С. G., Taber A., Truss M. et al. Die Phosphodiesteraseisoenzyme des humanen Corpus cavernosum Penis und deren funktionelle Bedeutung. Aktuel. Urol. 1995; 26: 58-61.
- Burnett A. L. Role of nitric oxide in the physiology of erection. Biol. Reprod. 1995; 52: 485-489.
- Wespes E. Smooth muscle pathology and erectile dysfunction.Int. J. Impotence Res. 2002; 14 (suppl. 1): 17-20.
- Miller M. A. W., Morgan R. J., Thompson С. S. Effects of papaverine and vasoactive intestinal polypeptide on penile and vascular cAMP and cGMP in control and diabetic animals: an in vitro study. Int. J. Impotence Res. 1995; 7: 91-98.
- Porst H. A rational for prostaglandin E@l in erectile failure: a survey of world-wide experience. J. Urol. (Baltimore) 1996; 155: 91-99.
- Daley J. Т., Brown M. L., Watkins M. T. et al. Prostanoid prduction in rabbit corpus cavernosum: Regulation by oxygen tension. J. Urol. (Baltimore) 1996; 155: 1482-1489.
- Saenz de Tejada I., Carson M. P., Morenas A. et al. Endothelin: localization, synthesis, activity and receptor types in the human penile corpus cavernosum. Am. J. Physiol. 1991; 261: 1078- 1086.
- Fisher C., Gross J., Zuch J. Cycle of penile erection synchronous with dreaming (REM) sleep. Preliminary report. Arch. Gen. Psychiatry 1965; 12: 29-45.
- Karacan I., Goodenough D. R, Shapiro A., Starker S. Erection cycle during sleep in relation to dream anxiety. Arch. Gen. Psychiatry 1996; 75: 183-188.
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