Efficacy of ciprofloxacine antibiotic prophylaxis of infectious complications after TUR of the prostate


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Abstract

We compared efficacy of preoperative prophylactic antibiotic treatment (PPAT) with cyprofloxacine used orally (0.5 g), intravenously (0.4 g) and routine antibiotics in TUR of the prostate. A multicenter open randomized study covered 120 patients. PPAT efficacy was estimated by the rate of urinary infection . frequency and
duration of antibiotic treatment in the postoperative period, hospitalization duration. All the patients were divided into three groups: 39 patients of group 1 received oral cyprofloxacine 90-120 min before TUR of the prostate, 38 patients of group 2 received intravenous cyprofloxacine 30-60 min before TUR, 43 patients of group 3 (control) received routine antibiotic prophylaxis. The following results were obtained: 24-48 hours after the operation no cases of UT in group 1, 11.5 and 11.6% in groups 2 and 3, respectively, (p = 0.048); 7 days
after TUR - Ul in all the groups (2.6, 20, 23.3%, respectively): 14 days after TUR - Ul in 5.1, 28.6, 27.9% patients, respectively. Mean duration of hospital stay was 11.7 + 7.6 days in group 1. 12.1 ±8.1 days in group 2, 12.5 ± 7.8 days in group С (p > 0.05). Postoperative antibiotics were given to 16.7, 34.1 and 68.9% patients, respectively. Thus, cyprofloxacine in group 1 lowered Ul risk and postoperative antibiotics significantly, in group 2 it had no influence on UT rate but reduced postoperative antibiotics significantly.

References

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