Protective properties of urothelium and possibilities of targeted pathogenetic therapy of chronic pelvic pain: sodium pentosan polysulfate


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Abstract

The review article is devoted to the possibilities of using targeted therapy for urothelial diseases, namely painful bladder syndrome (BPS). The protective structural components of the bladder mucosa, as well as their chemical features, are described in detail. Pentosanpolysulfate (PPS), being an oral heparinoid, can be used as part of pathogenetic therapy to restore the mucous membrane of the bladder. The efficacy and safety of this drug has been proven by us in a multicenter, randomized, double-blind, placebo-controlled trial. An additional assessment of the effectiveness and safety of the use of PPS in BPS was confirmed as part of our systematic review and meta-analysis. Thus, PPS is a pathogenetically sound tool in the treatment of patients with painful bladder syndrome

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About the authors

G. R Kasyan

A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia; City Clinical Hospital n.a. S.I. Spasokukotsky, Moscow Health Department

Email: g.kasyan@outlook.com
Doctor of Medical Sciences, Professor of the Department of Urology

A. V Zaitsev

A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia

Email: zaitcevandrew@mail.ru
Doctor of Medical Sciences, Professor of the Department of Urology

K. A Baibarin

Pride-Pharma

Email: 2baibarin@gmail.com

A. E Karasev

A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia

Email: alex-10k@mail.ru
Resident of the Department of Urology

D. Yu Pushkar

A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia; City Clinical Hospital n.a. S.I. Spasokukotsky, Moscow Health Department

Email: pushkardm@mail.ru
Honored Scientist of the Russian Federation, Chief Urologist of the Ministry of Health of the Russian Federation, Academician of the Russian Academy of Sciences, professor, doctor of medical sciences. Head of the Department of Urology

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