Role of the lower urinary tract viral infections in the development of female micturition disorders


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Currently, an increase in the incidence and reactivation of the lower urinary tract viral infections is seen in women that often manifest as various micturition disorders. The most common viral agents are herpes simplex virus types 1 and 2, Varicella-Zoster virus, Epstein-Barr virus, cytomegalovirus, and human papillomavirus. Since micturition disorders in bacterial cystitis and viral infections of the lower urinary tract are identical, urologists often prescribe antimicrobial drugs. This, in turn, not only has no effect in the treatment of micturition disorders, but also leads to the imbalances in the microflora of vagina and lower urinary tract, and, as a result, to the development of a chronic infectious process. This review presents the main characteristics, as well as features of the pathogenesis, diagnosis and treatment of the most common lower urinary tract viral infections.

Full Text

Restricted Access

About the authors

V. A Barsegian

Federal State Budgetary Educational Institution of Further Professional Education “Russian Medical Academy of Continuous Professional Education” of the Ministry of Healthcare of the Russian Federation

Email: vaganbarsegyan@gmail.com
MD, PhD student, Department of Urology and Surgical Andrology Moscow, Russia

I. V Kosova

Federal State Budgetary Educational Institution of Further Professional Education “Russian Medical Academy of Continuous Professional Education” of the Ministry of Healthcare of the Russian Federation

MD, Dr.Med.Sci, Professor at the Department of Urology and Surgical Andrology Moscow, Russia

References

  1. Slesarevskaja M.N., Ignashov Ju.A., Kuz’min I.V., Al’-Shukri S.H. Persistent dysuria in women: etiological diagnosis and treatment. Urologicheskie Vedomosti. 2021; 11(3): 195-204. doi: 10.17816/uroved81948.Russian (Слесаревская М.Н., Игнашов Ю.А., Кузьмин И.В., Аль-Шукри С.Х. Стойкая дизурия у женщин: этиологическая диагностика и лечение. Урологические ведомости. 2021;11(3):195-204).
  2. Dosin G., Aoun F., El Rassy E., Assi T., Lewalle.P, Blanc J., van Velthoven R., Bron D. Viral-induced Hemorrhagic Cystitis After Allogeneic Hematopoietic Stem Cell Transplant. Clin Lymphoma Myeloma Leuk. 2017;17(7):438-442. doi: 10.1016/j.clml.2017.05.013.
  3. Ambalathingal G.R., Francis R.S., Smyth M.J., Smith C., Khanna R. BK Polyomavirus: Clinical Aspects, Immune Regulation, and Emerging Therapies. Clin Microbiol Rev. 2017;30(2):503-528. Doi: 10.1128/ CMR.00074-16.
  4. Pinto M., Dobson S. BK and JC virus: a review. J Infect. 2014;68 Suppl 1:2-8. doi: 10.1016/j.jinf.2013.09.009.
  5. Badawi H., Ahmed H., Aboul Fadl L., Helmi A., Fam N., Diab M., Ismail A., Badawi A., Saber M. Herpes simplex virus type-2 in Egyptian patients with bladder cancer or cystitis. APMIS. 2010;118(1):37-44. doi: 10.1111/j.1600-0463.2009.02556.x
  6. Деревянко Т.И., Рыжков В.В. Вирусные инфекции: вирус папилломы человека и генитальный герпес 1 и 2 типов как причина хронического рецидивирующего цистита с выраженным дизурическим синдромом у женщин с гипоспадией и гипермобильностью уретры. Урология 2015; 4:29-33
  7. Kaplan S.A. Re: Urinary Frequency as a Possibly Overlooked Symptom in COVID-19 Patients: Does SARS-CoV-2 Cause Viral Cystitis? J Urol. 2020;204(5):1071-1072. doi: 10.1097/JU.0000000000001246.02.
  8. Mumm J.N., Osterman A., Ruzicka M., Stihl C., Vilsmaier T., Munker D., Khatamzas E., Giessen-Jung C., Stief C., Staehler M., Rodler S. Urinary Frequency as a Possibly Overlooked Symptom in COVID-19 Patients: Does SARS-CoV-2 Cause Viral Cystitis? Eur Urol. 2020;78(4):624-628. doi: 10.1016/j.eururo.2020.05.013.
  9. Синякова Л.А., Лоран О.Б., Косова И.В., Колбасов Д.Н., Незовибатько Я.И. Геморрагический цистит у женщин: диагностика и лечение. Экспериментальная и клиническая урология. 2020;13(5):92-98
  10. Abortive herpes simplex virus infection of nonneuronal cells results in quiescent viral genomes that can reactivate. Efrat M. Cohen, Nir Avital, Meir Shamay, Oren Kobiler. Proceedings of the National Academy of Sciences. 2020;117(1):635-640. doi: 10.1073/pnas.1910537117
  11. Зуйкова И.Н. Дифференциальная диагностика атипичной формы генитальной герпесвирусной инфекции и аллергодерматозов. Российский аллергологический журнал. 2007;1:20-29
  12. Boer A., Herder N., Blodorn-Schlicht N., Steinkraus V., Falk T.M. Refining criteria for diagnosis of cutaneous infections caused by herpes viruses through correlation of morphology with molecular pathology. Indian J Dermatol Venereol Leprol. 2006;72:270-275.
  13. Chayavichitsilp P., Buckwalter J.V., Krakowski A.C., Friedlander S.F. (April, 2009). «Herpes simplex». Pediatrics in Review. 30 (4): 119-129, quiz 130. doi: 10.1542/pir.30-4-119.
  14. Bernstein D.I., Bellamy A.R., Hook E.W. 3rd, Levin M.J., Wald A., Ewell M.G., et al. Epidemiology, clinical presentation, and antibody response to primary infection with herpes simplex virus type 1 and type 2 in young women. Clin Infect Dis. 2013;56(3):344-351.
  15. Roberts C.M., Pfister J.R., Spear S.J. Increasing proportion of herpes simplex virus type 1 as a cause of genital herpes infection in college students. Sex Transm Dis. 2003;30:797-800.
  16. Workowski K.A., Bachmann L.H., Chan P.A., Johnston C.M., Muzny C.A., Park I., Reno H., Zenilman J.M., Bolan G.A. Sexually Transmitted Infections Treatment Guidelines, 2021. MMWR Recomm Rep. 2021 ;70(4): 1-187. doi: 10.15585/mmwr.rr7004a1.
  17. Набока Ю.Л., Гудима И.А., Коган М.И., Ибишев Х.С., Чернитская М.Л. Микробный спектр мочи и биоптатов мочевого пузыря у женщин с хроническим рецидивирующим циститом. Урология. 2013;4:16-18
  18. Bradley H., Markowitz L.E., Gibson T., McQuillan G.M. Seroprevalence of herpes simplex virus types 1 and 2-United States, 1999-2010. J Infect Dis. 2014;209:325-333.
  19. Superti F., Longhi C., Di Biase A.M., Tinari A., Marchetti M., Pisani S., Gallinelli C., Chiarini F., Seganti L. Herpes simplex virus type 2 modulates the susceptibility of human bladder cells to uropathogenic bacteria. Med Microbiol Immunol. 2001;189(4):201-208. doi: 10.1007/s004300100067.
  20. Енькова, Е. В. Генитальный герпес: диагностика, актуальность супрессивной терапии, профилактика . Акушерство и гинекология. 2017;12:131-134). Doi 10.18565/ aig.2017.12.131-135
  21. Клинические рекомендации «Аногенитальная герпетическая инфекция», 2020. Общероссийская общественная организация «Российское общество дерматовенерологов и косметологов»
  22. Исаков В.А., Архипова Е.И., Исаков Д.В. Герпеcвирусные инфекции человека. 2-е изд. Под ред. В.А. Исакова. СПб., 2013. C. 670
  23. Kilgore P.E., Kruszon-Moran D., Seward J.F., Jumaan A., Van Loon F.P., Forghani B., McQuillan G.M., Wharton M., Fehrs L.J., Cossen C.K., Hadler S.C. Varicella in Americans from NHANES III: implications for control through routine immunization. J Med Virol. 2003;70 Suppl 1:S111-118. doi: 10.1002/jmv.10364.
  24. Gnann J.W. Jr, Whitley R.J. Clinical practice. Herpes zoster. N Engl J Med. 2002;347(5):340-346. doi: 10.1056/NEJMcp013211.
  25. Исаков В.А., Архипова Е.И., Исаков Д.В. Герпесвирусные инфекции человека. Руководство для врачей. СПб.: Спецлит, 2006: 302 с
  26. Sampathkumar P., Drage L.A., Martin D.P. Herpes zoster (shingles) and postherpetic neuralgia. Mayo Clin Proc. 2009;84(3):274-280. doi: 10.1016/S0025-6196(11)61146-4.
  27. Yawn B.P., Saddier P., Wollan P.C., St Sauver J.L., Kurland M.J., Sy L.S. A population-based study of the incidence and complication rates of herpes zoster before zoster vaccine introduction. Mayo Clin Proc. 2007;82(11):1341-1349. doi: 10.4065/82.11.1341.
  28. Chen P.H., Hsueh H.F., Hong C.Z. Herpes zoster-associated voiding dysfunction: a retrospective study and literature review. Arch Phys Med Rehabil. 2002;83(11):1624-1628. doi: 10.1053/apmr.2002.34602.
  29. Hsu C.Y., Lin C.L., Kao C.H. Association between Chronic Interstitial Cystitis and Herpes Zoster.Int J Environ Res Public Health. 2020;17(7):2228. doi: 10.3390/ijerph17072228.
  30. Broseta E., Osca J.M., Morera J., Martinez-Agullo E., Jimenez-Cruz J.F. Urological manifestations of herpes zoster. Eur Urol 1993;24:244-247.
  31. Fujii M., Takahashi I., Honma M., Ishida-Yamamoto A. Close correlation of herpes zoster-induced voiding dysfunction with severity of zoster-related pain: A single faculty retrospective study. J Dermatol. 2015;42(11):1091-1093. doi: 10.1111/1346-8138.12957.
  32. Saito H., Ebashi M., Kushimoto M., Ikeda J., Egashira F., Yamaguchi S., Watanabe K., Ogawa K., Suzuki Y., Ishihara H., Fujishiro M. Elsberg syndrome related to varicella zoster virus infection with painless skin lesions in an elderly woman with poorly controlled type 2 diabetes mellitus. Ther Clin Risk Manag. 2018;14:1951-1954. doi: 10.2147/TCRM.S178782.
  33. Клинические рекомендации «Опоясывающий герпес», 2020. Общероссийская общественная организация «Российское общество дерматовенерологов и косметологов»
  34. Broseta E., Osca J.M., Morera J., Martinez-Agullo E., Jimenez-Cruz J.F. Urological manifestations of herpes zoster. Eur Urol. 1993;24: 244-47.
  35. Yamanishi T., Yasuda K., Sakakibara R., et al. Urinary retention due to herpes virus infections. Neurourol Urodynam. 1998;17:613-619.
  36. Турбина Л.Г., Савушкин А.Н., Штанг О.М. Поражение нервной системы вирусом опоясывающего герпеса: клиника, диагностика, лечение. Эффективная фармакотерапия. 2011;20:14-16
  37. Werner R.N., Nikkels A.F., Marinovic B., Schafer M., Czarnecka-Operacz M., Agius A.M., Bata-Csorgo Z., Breuer J., Girolomoni G., Gross G.E., Langan S., Lapid-Gortzak R., Lesser T.H., Pleyer U., Sellner J., Verjans G.M., Wutzler P., Dressler C., Erdmann R., Rosumeck S., Nast A. European consensus-based (S2k) Guideline on the Management of Herpes Zoster -guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV), Part 2: Treatment. J Eur Acad Dermatol Venereol. 2017;31(1):20-29. doi: 10.1111/jdv.13957.
  38. de-The G., Day N.E., Geser A., et al. Sero-epidemiology ofthe Epstein-Barr virus: Preliminary analysis of an international study - a review. IARC Sci. Publ.1975:3-16.
  39. Dunmire S.K., Verghese P.S., Balfour H.H. Jr. Primary Epstein-Barr virus infection. J Clin Virol. 2018;102:84-92. doi: 10.1016/j.jcv.2018.03.001.
  40. Thorley-Lawson D.A., Gross A. Persistence of the Epstein-Barr virus and the origins of associated lymphomas. N Engl J Med. 2004;350(13):1328-1337. doi: 10.1056/NEJMra032015.
  41. Ascherio A., Munger K.L., Lunemann J.D. The initiation and prevention of multiple sclerosis. Nat. Rev. Neurol. 2012;8:602-612.
  42. Draborg A.H., Duus K., Houen G. Epstein-Barr Virus in Systemic Autoimmune Diseases. Clin Dev Immunol. 2013;2013:535738.
  43. Набока Ю.Л., Коган М.И., Морданов С.В., Ибишев Х.С., Ильяш А.В., Гудима И.А. Бактериальновирусная микробиота мочи при неосложненной рецидивирующей инфекции нижних мочевых путей (пилотное исследование). Вестник урологии. 2019;7(4):13-19
  44. Maeda D., Akiyama Y., Morikawa T., Kunita A., Ota Y., Katoh H., Niimi A., Nomiya A., Ishikawa S., Goto A., Igawa Y., Fukayama M., Homma Y. Hunner-Type (Classic) Interstitial Cystitis: A Distinct Inflammatory Disorder Characterized by Pancystitis, with Frequent Expansion of Clonal B-Cells and Epithelial Denudation. PLoS One. 2015; 10(11):e0143316. doi: 10.1371/journal.pone.0143316.
  45. Ok C.Y., Li L., Young K.H. EBV-driven B-cell lymphoproliferative disorders: from biology, classification and differential diagnosis to clinical management. Exp Mol Med. 2015;47(1): e132. doi: 10.1038/emm.2014.82.
  46. Jhang J.F., Hsu Y.H., Peng C.W., Jiang Y.H., Ho H.C.,Kuo H.C. Epstein-Barr Virus as a Potential Etiology of Persistent Bladder Inflammation in Human Interstitial Cystitis/Bladder Pain Syndrome. J Urol. 2018;200(3):590-596. doi: 10.1016/j.juro.2018.03.133.
  47. De Paschale M., Clerici P. Serological diagnosis of Epstein-Barr virus infection: Problems and solutions. World J Virol. 2012;1(1):31-43. doi: 10.5501/wjv.v1.i1.31.
  48. Bennett J., Dolin R, Blaser M. Mandell, Douglas, and Bennett’s principles and practice of infectious diseases. 9th edition. Elsevier/Saunders; 2015.
  49. Spach D.H., Bauwens J.E., Myerson D., Mustafa M.M., Bowden R.A. Cytomegalovirus-induced hemorrhagic cystitis following bone marrow transplantation. Clin Infect Dis. 1993;16(1):142-144. Doi: 10.1093/ clinids/16.1.142.
  50. Tutuncuoglu S.O., Yanovich S., Ozdemirli M. CMV-induced hemorrhagic cystitis as a complication of peripheral blood stem cell transplantation: case report. Bone Marrow Transplant. 2005;36(3):265-266. Doi: 10.1038/ sj.bmt.1705030.
  51. Xu L.P., Zhang H.Y., Huang X.J., Liu K.Y., Liu D.H., Han W., Chen H., Chen Y.H., Gao Z.Y., Zhang Y.C., Lu D.P. Hemorrhagic cystitis following hematopoietic stem cell transplantation: incidence, risk factors and association with CMV reactivation and graft-versus-host disease. Chin Med J (Engl). 2007;120(19):1666-1671.
  52. Hariri S., Unger E.R., Sternberg M., Dunne E.F., Swan D., Patel S., et al. Prevalence of genital human papillomavirus among females in the United States, the National Health And Nutrition Examination Survey, 2003-2006. J Infect Dis. 2011;204(4):566-573.
  53. Клинические рекомендации «Аногенитальные (венерические) бородавки», 2020. Общероссийская общественная организация «Российское общество дерматовенерологов и косметологов», Российская ассоциация колопроктологов
  54. Nebesio C.L., Mirowski G.W., Chuang T.Y. Human papillomavirus: clinical significance and malignant potential.Int J Dermatol. 2001;(6):373-379.
  55. Bosch F.X., Manos M.M., Munoz N., et al. Prevalence of human papillomavirus in cervical cancer: a worldwide perspective.International biological study on cervical cancer (IBSCC) Study Group. J Natl Cancer Inst. 1995;87(11):796-802.
  56. Parkin D.M., Bray F. Chapter 2: The burden of HPV-related cancers. Vaccine. 2006;24(Suppl 3):S3/11-25.
  57. Luria L., Cardoza-Favarato G. Human Papillomavirus. [Updated 2021 Jan 24]. In: Stat Pearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021.
  58. Ибишев Х.С., Крахоткин Д.В., Васильев А.А., Крайний П.А. Рецидивирующая инфекция нижних мочевых путей вирусной этиологии. Вестник урологии. 2017;5(1):26-31
  59. Ибишев Х.С., Крахоткин Д.В., Лаптева Т.О., Тодоров С.С., Рябенченко Н.Н., Манцов А.А., Коган М.И. Эндоскопические и морфологические признаки хронического рецидивирующего папилломавирусного цистита. Урология. 2021;3:45-49. DOI: https://dx.doi.org/10.18565/urology.2021.3.45-49
  60. Badawi H., Ahmed H., Ismail A., Diab M., Moubarak M., Badawy A., Saber M. Role of human papillomavirus types 16, 18, and 52 in recurrent cystitis and urinary bladder cancer among Egyptian patients. Medscape J Med. 2008;10(10):232

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies