Evolution of views on the etiology and pathogenesis of lower urinary tract symptoms for men


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The review article in the format of a «Lecture for Doctors» examines the evolution of terminology reflecting various disorders of urination and understanding their etiology and pathogenesis from a methodological and historical point of view. Symptoms of the lower urinary tract (LUTS) is a new term that replaced the term «Dysuria» that previously existed in the literature and suggests the allocation of various groups of symptoms depending on the violation of key functions of the bladder, which greatly facilitates obtaining reliable information about the state of urination in a particular patient. However, for a long time, LUTS were identified exclusively with urological pathology. Thanks to the fundamental research of recent decades, it has become obvious that LUTS is an interdisciplinary problem involving various specialists in the process of diagnosis and correction. One of the current trends in the study of the urination pathophysiology is the influence of systemic hormonal and metabolic disorders in men, which are considered as independent factors of the LUTS. The role of testosterone deficiency in the pathogenesis of LUTS is highlighted and the safety and effectiveness of testosterone replacement therapy (TRT) in hypogonadal men with LUTS is shown

Full Text

Restricted Access

About the authors

I. A Tyuzikov

Medical Center «Tandem-Plus»

Email: phoenix-67@list.ru
Cand.Med.Sci., professor of the Russian Academy of Natural History (RANH), urologist-andrologist Yaroslavl, Russia

Yu. A Tishova

Clinic «К-Medicine»

Email: yulya_tishova@mail.ru
Cand.Med.Sci., endocrinologist Moscow, Russia

References

  1. Урология. Иллюстрированное руководство. От симптомов к диагнозу и лечению. Под редакцией П.В. Глыбочко, Ю.Г. Аляева, Н.А. Григорьева. М.: ГОЭТАР-Медиа, 2014. 248 с
  2. Урология. Национальное руководство. Под ред. Н.А. Лопаткина. М.: ГОЭТАР-Медиа, 2013. 1024 с
  3. Abrams P., Cardozo L., Fall M., Griffiths D., Rosier P., Ulmsten U., van Kerrebroeck P., Victor A., Wein A, Standardisation Sub-committee of the International Continence Society. The standardization of terminology of lower urinary tract function: report from the Standardization Subcommittee of the International Continence Society. Neurourol Urodyn. 2002. 21(2): 167-178. doi: 10.1002/nau.10052.
  4. EAU Guidelines on Management of Non-Neurogenic Male Lower Urinary Tract Symptoms (LUTS), incl. Benign Prostatic Obstruction (BPO) Gravas S., Cornu J.N., Gacci M. et al. European Association of Urology, 2022. 112 р.
  5. Резолюции по итогам Экспертного Совета по проблемам дифференцированного подхода к терапии СНМП. Урология. 2019;4:6-8
  6. Mohamad Anuar M.F., Solihin Rezali M., Mohamed Daud M.A., Ismail S.B. A community-based study on lower urinary tract symptoms in Malaysian males aged 40 years and above. Sci Rep. 2022;12(1):2345. Doi: 10.1038/ s41598-022-05890-9.
  7. Cheng M.C., Liu S.P., Chuang Y.C. et al. Prevalence and impacts of male urinary incontinence on quality of life, mental health, work limitation, and health care seeking in China, Taiwan, and South Korea (LUTS Asia): Results from a cross-sectional, population-based study. Investig Clin Urol. 2022; 63(1):71-82. doi: 10.4111/icu.20210259.
  8. Cornu J.N., Abrams P., Chapple C.R. et al. A Contemporary Assessment of Nocturia: Definition, Epidemiology, Pathophysiology, and Management - a Systematic Review and Meta-analysis. Eur Urol. 2012;62(1):877-890. doi: 10.1016/j.eururo.2012.07.004.
  9. Zhang A.Y., Xu X. Prevalence, Burden, and Treatment of Lower Urinary Tract Symptoms in Men Aged 50 and Older: A Systematic Review of the Literature. SAGE Open Nurs. 2018;4:2377960818811773. doi: 10.1177/2377960818811773.
  10. Soysal P., Cao C., Xu T. et al. Trends and prevalence of nocturia among US adults, 2005-2016.Int Urol Nephrol. 2020;52(5):805-813. doi: 10.1007/ s11255-019-02361-5.
  11. Xin C., Fan H., Xie J. et al. Impact of Diabetes Mellitus on Lower Urinary Tract Symptoms in Benign Prostatic Hyperplasia Patients: A Meta-Analysis. Front Endocrinol (Lausanne). 2022;12:741748. Doi: 10.3389/ fendo.2021.741748.
  12. Martin S.A., Tully P.J., Kahokehr A.A. et al. The bidirectional association between depression and lower urinary tract symptoms (LUTS) in men: A systematic review and meta-analysis of observational studies. Neurourol Urodyn. 2022;41(2):552-561. doi: 10.1002/nau.24868.
  13. He Q., Wang H., Yue Z. et al. Waist circumference and risk of lower urinary tract symptoms: a meta-analysis. Aging Male. 2014;17(4):223-229. doi: 10.3109/13685538.2014.967671.
  14. Gacci M., Corona G., Sebastianelli A. et al. Male Lower Urinary Tract Symptoms and Cardiovascular Events: A Systematic Review and Metaanalysis. Eur Urol. 2016;70(5):788-796. doi: 10.1016/j.eururo.2016.07.007.
  15. Раснер П.И., Газимиев М.А., Гаджиева З.К., Касян Г.Р. Расстройства мочеиспускания у мужчин. М.: ИД «АБВ-пресс», 2017. 42 с
  16. Tahra A., Bayrak О., Dmochowski R. The Epidemiology and Population-Based Studies of Women with Lower Urinary Tract Symptoms: A Systematic Review. Turk J Urol. 2022;48(2):155-165. doi: 10.5152/tud.2022.21325
  17. Тюзиков И.А., Калинченко С.Ю., Ворслов Л.О., Тишова Ю.А. Место андрогенного дефицита в клиническом портрете современного урологического пациента. Андрология и генитальная хирургия. 2013;14(3):48-57. https://doi.org/10.17650/2070-9781-2013-3-48-57
  18. Тюзиков И.А., Греков Е.А., Калинченко С.Ю. Особенности клинического течения и морфометрических параметров доброкачественной гиперплазии предстательной железы (ДГПЖ) у мужчин с метаболическим синдромом и андрогенным дефицитом. Урология. 2015;5:66-69
  19. Шорманов И.С., Соловьев А.С., Тюзиков И.А., Куликов С.В. Анатомо-физиологические и патофизиологические особенности нижних мочевых путей в гендерном и возрастном аспектах. Урологические ведомости. 2021;11(3):241-256. https://doi.org/10.17816/uroved70710
  20. Братчиков О.И., Тюзиков И.А., Артищев С.О. Системные гормонально-метаболические механизмы патогенеза аденомы предстательной железы. Курск: Изд-во КГМУ, 2019. 150 с
  21. Тюзиков И.А., Калинченко С.Ю Доброкачественная гиперплазия предстательной железы (ДГПЖ) как системное гормонально-метаболическое заболевание: время изменить парадигмы патогенеза и фармакотерапии. Эффективная фармакотерапия. 2016;3:32-53
  22. Traish A.M., Johansen V. Impact oftestosterone deficiency and testosterone therapy on lower urinary tract symptoms in men with metabolic syndrome. World J. Men’s Health. 2018;36(3):199-222. doi: 10.5534/wjmh.180032.
  23. Rohrmann S., Nelson W.G., Rifai N. et al. Serum sex steroid hormones and lower urinary tract symptoms in Third National Health and Nutrition Examination Survey (NHANES III). Urol. 2007;69(4):708-713. doi: 10.1016/j.urology.2007.01.011.
  24. Тюзиков И.А. Симптомы нижних мочевых путей на фоне ДГПЖидефицита тестостерона - есть ли связь? Общие вопросы терминологии, методологии и возрастной эпидемиологии. Фармакология & Фармакотерапия. 2020;1:65-73. doi: 10.46393/2713-2129_2020_1_65
  25. Старцев В.Ю., Иванов Н.В., Дударев В.А. Нарушение функции нижних мочевых путей у мужчин с гипогонадизмом и метаболическим синдромом. Экспериментальная и клиническая урология. 2019;1:95- 100. doi: 10.29188/2222-8543-2019-11-1-95-100
  26. Тюзиков И.А. Патогенетические механизмы влияния дефицита тестостерона на симптомы нижних мочевых путей у мужчин. Эффективная фармакотерапия. 2020; 16(20) :32-42. doi: 10.33978/2307-3586-202016-20-32-42
  27. Kohn T.P., Mata D.A, Ramasamy R., Lipshultz L.I. Effects of Testosterone Replacement Therapy on Lower Urinary Tract Symptoms: A Systematic Review and Meta-analysis. Eur Urol. 2016;69(6):1083-1090. doi: 10.1016/j.eururo.2016.01.043.
  28. Karazindiyanoglu S., Cayan S. The effect of testosterone therapy on lower urinary tract symptoms/bladder and sexual functions in men with symptomatic late-onset hypogonadism. Aging Male. 2008;11(3):146-149. doi: 10.1080/13685530802290438.
  29. Haider A., Gooren L.J., Padungtod P., Saad F. Concurrent improvement of the metabolic syndrome and lower urinary tract symptoms upon normalisation of plasma testosterone levels in hypogonadal elderly men. Androl. 2009;41(1):7-13. doi: 10.1111/j.1439-0272.2008.00880.x.
  30. Kalinchenko S.YU., Vishnevskiy E.L., Koval A.N. et al. Beneficial effects of testosterone administration on symptoms of the lower urinary tract in men with late-onset hypogonadism: a pilot study. Aging Male. 2008;11(2):57-doi: 10.1080/13685530801953994.
  31. Amano T., Imao T., Takemae K. et al. Testosterone replacement therapy by testosterone ointment relieves lower urinary tract symptoms in late onset hypogonadism patients. Aging Male. 2010;13(4):242-246. doi: 10.3109/13685538.2010.487552.
  32. La Vignera S., Aversa A., Cannarella R. et al. Pharmacological treatment of lower urinary tract symptoms in benign prostatic hyperplasia: consequences on sexual function and possible endocrine effects. Expert Opin Pharmacother. 2021;22(2):179-189. doi: 10.1080/14656566.2020.1817382.
  33. Salonia A., Bettocchi C., Carvalho J. et al. Anheim (NL): European Association of Urology; c2020. EAU Guidelines on Sexual and Reproductive Health. EAU guidelines 2020 [Internet] [cited 2020 Jan 1].
  34. Corona G., Goulis D.G., Huhtaniemi I. et al. European Academy of Andrology (EAA) guidelines on investigation, treatment and monitoring of functional hypogonadism in males: Endorsing organization: European Society of Endocrinology. Androl. 2020;8(5):970-987. Doi: 10.1111/ andr.12770.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies