Selzink plus study in patients with chronic non-infectious prostatitis and abnormal fertility


Cite item

Full Text

Abstract

Correction of subnormal spermatogenesis caused by chronic prostatitis is made with application of different therapeutic schemes. Our aim was to investigate efficacy of selzink medicine which corrects deficiency of trace elements Se and Zn in ejaculate and thus improves spermatogenesis. One-month course of therapy produced no side effects, had a positive effect on low fertility of ejaculate. Therefore, selzink can be recommended in combined treatment of male infertility.

References

  1. Фофанова И. Ю. Современные поливитаминные препараты (обзор литературы). Патол. беременности 2004; 6(2).
  2. Скальный А. В. Химические элементы в физиологии и экологии человека. М.: Изд. дом "ОНИКС 21 век": Мир; 2004.
  3. Николаев В. В., Строев В. А., Астраханцев А. Ф. Биохимические исследования спермоплазмы при мужском бесплодии. Урол. и нефрол. 1993; 3: 33-36.
  4. Скальный А. В. Цинк и здоровье человека. Оренбург: РИО ГОУ ОГУ; 2003.
  5. Gomez Y., Arocha F., Espinoza F. et al. Zinc levels in prostatic fluid of patients with prostate pathologies. Invest. Clin. 2007; 48(3): 287-294.
  6. Kumar N., Verma R. P. et al. Effects of different levels and sources of zinc supplementation on quantitative and qualitative semen attributes and serum testosterone level in crossbred cattle (Bos indicus x Bos taurus) bulls. Reprod. Nutr. Dev. 2006; 46(6): 663-675.
  7. Полунин А. И., Мирошников В. М. и др. Использование препарата цинка в лечении мужской субфертильности. Микроэлементы в мед. 2001; 2(4): 44-46.
  8. Ebisch I. M., Thomas C. M., Peters W. H. et al. The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility. Hum. Reprod. Update 2007; 13(2): 163- 174.
  9. Prasad A. S. Clinical, immunological, anti-inflammatory and antioxidant roles of zinc. Exp. Gerontol. 2008; 43(5): 370-377.
  10. Анисимов В. Н. Современные представления о природе старения. Успехи соврем. биол. 2000; 2: 156-164.
  11. Горбачев А. Л., Скальный А. В., Ефимова А. В. Физиологическая роль селена и вариации его содержания в организме жителей Северо-Востока России. Микроэлементы в мед. 2001; 2(4): 31-36.
  12. Авцын А. П. Недостаточность эссенциальных микроэлементов и ее проявление в патологии. Арх. пат. 1990; 3: 3-8.
  13. Combs G. F. Jr., Clark L. C., Turnbull B. W. An analysis of cancer prevention by selenium. Biofactors 2001; 14(1-4): 153- 159.
  14. Clark L. C., Combs G. F., Turnbull B. W. The nutritional prevention of cancer with selenium 1983-1993: A randomized clinical trial. J. A. M. A. 1996; 276. P. 1957-1963.
  15. Galan P., Brancon S., Favier A. et al. Antioxidant status and risk of cancer in the SU. VI. MAX study: is the effect of supplementation depend on baseline levels? Br. J. Nutr. 2005; 94(1): 125-132.
  16. Clark L. C., Graham G. F., Turnbull B. W. et al. Nonmelanoma skin cancer and plasma selenium: a prospective cohort study. In: Combs G. F., Spallholz J. E., Levander O. A., Oldfield J. E., eds. The 3rd International symposium on selenium in biology and medicine. Westport;
  17. Clark L. C., Cantor K. P., Allaway W. H. Selenium in forage crops and cancer mortality in US counties. Arch. Environ. Hlth 1991; 46: 37-42.
  18. Голубкина Н. А., Соколов Я. А. Роль селена в возникновении и развитии рака простаты. Микроэлементы в мед. 2001; 2(4): 17-22.
  19. Dodig S., Cepelak I. The facts and controversies about selenium. Acta Pharm. 2004; 54(4): 261-276.
  20. Seema P., Swathy S. S., Indira M. Protective effect of selenium on nicotineinduced testicular toxicity in rats. Biol. Trace Elem. Res. 2007; 120(1-3): 212-218.
  21. Swathy S. S., Panicker S., Indira M. Effect of exogenous selenium on the testicular toxicity induced by ethanol in rats. Indian J. Physiol. Pharmacol. ; 50(3): 215-224.
  22. Shalini S., Bansal M. P. Co-operative effect of glutathione depletion and selenium induced oxidative stress on API and NFkB expression in testicular cells in vitro: insights to regulation of spermatogenesis. Biol. Res. 2007; 40(3): 307-317.
  23. Dimitrov S. G., Atanasov V. K., Surai P. F., Denev S. A. Effects of organic selenium on turkey semen quality during liquid storage. Anim. Reprod. Sci. ; 100(3-4): 311-317.
  24. Safarinejad M. R., Safarinejad S. Efficacy of selenium and/or N-acetylcysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study. J. Urol. (Baltimore) 2009; 181(2): 741-751.
  25. Ebisch I. M., Thomas C. M., Peters W. H. et al. The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility. Hum. Reprod. Update 2007; 13(2): 163- 174.
  26. Colagar A. H., Marzony E. T., Chaichi M. J. Zinc levels in seminal plasma are associated with sperm quality in fertile and infertile men. Nutr. Res. 2009; 29(2): 82-88.
  27. Ghasemi N., Babaei H., Azizallahi S., Kheradmand A. Effect of long-term administration of zinc after scrotal heating on mice spermatozoa and subsequent offspring quality. Andrologia 2009: 41(4): 222-228.
  28. Yuyan I., Junqing W., Wei Y. et al. Are serum zinc and copper levels related to semen quality? Fertil. and Steril. 2008; 89(4): 1008-1011.

Supplementary files

Supplementary Files
Action
1. JATS XML

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies