ALTERATION OF VHL GENE IN PATIENTS WITH METASTATIC RENAL CELL CARCINOMA


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Blocks of preparations from 22 patients with metastatic renal cell carcinoma on target therapy were studied. The patients were examined for mutations/methylation of VHL gene. The mutations were detected in 10(45.5%) of 22 patients, VHL methylation was found in 1 (4.5%) patient. Overall survival was 36.4 and 66.7% in the groups of patients with and without gene VHL alteration, respectively. Progression-free survival was 47.6 and 57.1%, respectively (p=0.619), relapse-free survival — 63.6 and 45.5%, respectively (p=0.682), progression was registered in 36.4 and 54.5%, respectively (p=0.682). Gene VHL inactivation had no effect on prognosis of the disease and results of anti-angiogenic therapy.

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