Efficiency of safocid in the prevention of infectious and inflammatory complications after prostate biopsy


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The article is dedicated to the evaluation of the efficacy and safety of use of combined drug «Safocid» during transrectal prostate biopsy. The study included 80 patients with suspected prostate cancer who had indications for prostate biopsy. The study group (n = 40) of patients has received safocid, the control group (n = 40) of patients - pefloxacin at a dose 400 mg twice a day. Patients treated with safotsid significantly less often have reported the development of febrile hyperthermia on the 1st day after the biopsy; there was no need for changing the drug in study group compared with 6 (15%) patients in the control group. The frequency of adverse effects was not significantly different in the groups. Another positive feature of safocid is its satisfactory compliance and psychological comfort of patients used this drug. The data obtained allow to recommend the use of safocid for antibacterial prophylaxis when performing a prostate biopsy.

Full Text

Restricted Access

About the authors

D. V Ergakov

A. G Martov

Email: martovalex@mail.ru

References

  1. Nam R.K., Saskin R., Lee Y. et al. Increasing hospital admission rates for urological complications after transrectal ultrasound guided prostate biopsy. J Urol. 2013; 189(Suppl. 1): S. 12—17.
  2. Zani E.L., Clark O.A., Rodrigues Netto Jr N. Antibiotic prophylaxis for transrectal prostate biopsy. Cochrane Database Syst Rev. 2011, CD006576.
  3. Yang M., Zhao X., Wu Z. et al. Meta-analysis of antibiotic prophylaxis use in transrectal prostatic biopsy. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009; 34: 115-123.
  4. American Urological Association. Best practice policy statement on urologic surgery antimicrobial prophylaxis. American Urological Association Web site. https://www.auanet.org/common/pdf/education/clinical-guidance/Antimicrobial-Prophylaxis.pdf. Accessed February 22, 2013.
  5. Wagenlehner F.M., van Oostrum E., Tenke P. et al. Infective complications after prostate biopsy: outcome of the Global Prevalence Study of Infections in Urology (GPIU) 2010 and 2011, a prospective multinational multicentre prostate biopsy study. Eur. Urol. 2013; 63: 521-527.
  6. Carmignani L., Picozzi S., Spinelli M. et al. Bacterial sepsis following prostatic biopsy. Int. Urol. Nephrol. 2012; 44: 1055-1063.
  7. Feliciano J., Teper E., Ferrandino M. et al. The incidence of fluoroquinolone resistant infections after prostate biopsy - are fluoroquinolones still effective prophylaxis? J Urol. 2008; 179: 952-955.
  8. Zaytoun O.M., Vargo E.H., Rajan R. et al. Emergence of fluoroquinolone-resistant Escherichia coli as cause of postprostate biopsy infection: implications for prophylaxis and treatment. Urology. 2011; 77: 1035-1041.
  9. Mosharafa A.A., Torky M.H., El Said W.M. et al. Rising incidence of acute prostatitis following prostate biopsy: fluoroquinolone resistance and exposure is a significant risk factor. Urology. 2011; 78: 511-514.
  10. Dalhoff A. Global fluoroquinolone resistance epidemiology and implications for clinical use. Interdiscip Perspect Infect Dis. 2012; 2012: 976273.
  11. Loeb S. Antimicrobial prophylaxis for transrectal ultrasound biopsy. AUA Update Series. 2013; 32: 1-8.
  12. Gil-Vernet Sedo J.M., Alvarez-Vijande Garcia R. Effect of intrarectal povidone-iodine in the incidence of infectious complications after transrectal prostatic biopsy. Arch. Esp. Urol. 2012; 65: 463-446.
  13. Abughosh Z., Margolick J., Goldenberg S.L. et al. A prospective randomized trial of povidone-iodine prophylactic cleansing of the rectum before transrectal ultrasound guided prostate biopsy. J Urol. 2013; 189: 1326-1331.
  14. Park D.S., Oh J.J., Lee J.H. et al. Simple use of the suppository type povidone-iodine can prevent infectious complications in transrectal ultrasound-guided prostate biopsy. Adv Urol. 2009: 750598.
  15. Lange D., Zappavigna C., Hamidizadeh R. et al. Bacterial sepsis after prostate biopsy - a new perspective. Urology 2009; 74: 1200-1205.

Supplementary files

Supplementary Files
Action
1. JATS XML

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies