HORMONAL AND METABOLIC DISORDERS AS SYSTEMIC FACTOR FOR THE FORMATION OF UROLITHS
- Authors: Alyaev Y.G1, Egshatyan L.V2, Rapoport L.M1, Lartsova E.V.1
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Affiliations:
- SBEI HPE First MSMU n.a. I.M. Sechenov
- FSBI «State Scientific Research Center for Preventive Medicine»
- Issue: No 5 (2014)
- Pages: 35-39
- Section: Articles
- URL: https://journals.eco-vector.com/1728-2985/article/view/280284
- ID: 280284
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Abstract
In patients suffering from urolithiasis, metabolic diagnostics often reveals abnormalities contributing to the formation of stones: hypocitraturia, hyper- and hypocalcemia, hypercalciuria, hypomagnesemia/hypomagnesuria, hyperoxalaturia, etc. Before surgery, complex biochemical examination of blood and 24-hourcollection urine in 82 patients with urolithiasis was performed. The analysis of the main laboratory parameters of carbohydrate, lipid, calcium and phosphorus and purine metabolism found the prevalence of violations of calcium and phosphorus metabolism in these patients. Dyslipidemia was diagnosed in 31 (37.8%) patients. There was a significant positive correlation between serum total cholesterol and serum total calcium (rs = 0.3315, P = 0.0103). Low serum calcium levels were associated with hyperoxalaturia (rs = -0.4270, P = 0.0295). There was a significant effect of natriuria on urinary excretion of oxalate (rs = 0.6107, P = 0.0001), Mg (rs = 0.4156, P = 0.0096) and K (rs = 0.5234, P = 0.00005). The study shows the role of magnesium in the prevention of recurrence and manifestation of urolithiasis. The combination of two or more types of hormonal and metabolic disorders increases the incidence of recurrent stones. Timely correction of hormonal-metabolic status allows to reduce the risk of stone formation, and hospitalization attributable to the complications associated.
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About the authors
Yu. G Alyaev
SBEI HPE First MSMU n.a. I.M. SechenovSRI of Uronephrology and Human Reproductive Health
L. V Egshatyan
FSBI «State Scientific Research Center for Preventive Medicine»
L. M Rapoport
SBEI HPE First MSMU n.a. I.M. SechenovSRI of Uronephrology and Human Reproductive Health
Ekaterina Viktorovna Lartsova
SBEI HPE First MSMU n.a. I.M. Sechenov
Email: ekaterina_larcova@inbox.ru
Researcher at the SRI of Uronephrology and Human Reproductive Health
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