DIAGNOSIS AND TREATMENT OF LOCAL RECURRENCE OF PROSTATE CANCER USING HYSTOSCANNING AND HIGH-INTENSITY FOCUSED ULTRASOUND IN PATIENTS AFTER RADICAL PROSTATECTOMY


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The study was aimed to the improvement of the diagnosis and treatment of patients with prostate cancer (PC). The study included 46 patients with recurrent prostate cancer after radical prostatectomy (RPE). The examination included contrast enhanced magnetic resonance imaging (endorectal coil 1.5T) and hystoscanning. All patients had local recurrence confirmed by the morphologically results of transrectal biopsy of the area of vesicourethral anastomosis. All patients underwent high-intensity focused ultrasound (HIFU). Before RPE, protate volume ranged from 21 to 102 cm3. The median age was 62 (46-68) years. PSA levels before a HIFU session ranged from 0.4 to 18 ng/ml. Nadir PSA level after 3 months of follow up was 0.1 ng/ ml. Five-year disease-free survival in patients with locally recurrent prostate cancer after HIFU in the group of low cancer risk was 10 (81%), moderate risk - 18 (57%), high risk - 12 (42%). Contrast enhanced magnetic resonance imaging and hystoscanning are highly informative methods for diagnosis of local recurrence after radical prostatectomy, and HIFU can be categorized as highly effective treatment.

Full Text

Restricted Access

About the authors

P. V Glybochko

SBEI HPE First MSMU n.a. I.M. Sechenov

Department of Urology

Yu. G Alyaev

SBEI HPE First MSMU n.a. I.M. Sechenov

Department of Urology

G. E Krupinov

SBEI HPE First MSMU n.a. I.M. Sechenov

Email: Gekrupinov@mail.ru
MD, Prof., Head of Teaching Department

L. M Rapoport

SBEI HPE First MSMU n.a. I.M. Sechenov

Department of Urology

N. A Amosov

SBEI HPE First MSMU n.a. I.M. Sechenov

Department of Urology

E. A Bezrukov

SBEI HPE First MSMU n.a. I.M. Sechenov

Department of Urology

N. D Novichkov

SBEI HPE First MSMU n.a. I.M. Sechenov

Department of Urology

E. L Lachinov

SBEI HPE First MSMU n.a. I.M. Sechenov

Department of Urology

T. M Ganzha

SBEI HPE First MSMU n.a. I.M. Sechenov

Department of Urology

A. A Obukhov

SBEI HPE First MSMU n.a. I.M. Sechenov

Department of Urology

Yu. V Lerner

SBEI HPE First MSMU n.a. I.M. Sechenov

Department of Urology

References

  1. Сивков А.В., Кудрявцев Ю.В., Кешишев Н.Г. и др. HIFU-терапия местного рецидива рака предстательной железы после простатэктомии. Экспериментальная и клиническая урология. 2010;2.
  2. Крупинов Г.Е. Лечение больных раком предстательной железы высокоинтенсивным фокусированным ультразвуком. Дисс. докт. мед. наук, М., 2010.
  3. Лопаткин Н.А., Сивков А.В., Аполихин О.И., Мартов А.Г., Чернов Н.А. Рак предстательной железы (компакт-диск). - НИИ урологии Минздрава РФ, 2002.
  4. Братчиков О.И. Ильченко В.А., Шумакова Е.А., Бабенко В.В., Ишков И.Н. Некоторые аспекты диагностики и лечения рака предстательной железы. Материалы I конгресса РООУ, 4-5 октября 2006. М.
  5. Blana A., Walter B., Rogenhofer S., Wieland W.F. High-intensity focused ultrasound for the treatment of localized prostate cancer: 5-year experience. Urology. 2004; 63(2): 297-300.
  6. Azzouz Н. HIFU: Local Treatment of Prostate Cancer. - EAU-EBU Update Series 4. 2006;62-70.
  7. Урология: учебник / Под ред. П.В. Глыбочко, Ю.Г. Аляева. М., 2013.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies