Injection of botulinum toxin type a in the bladder detrusor and submucosa in patients with overactive bladder without detrusor overactivity
- Authors: Krivoborodov G.G1, Tur E.I1, Efremov N.S1
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Affiliations:
- RNRMU n. a. N.I. Pirogov
- Issue: No 2 (2015)
- Pages: 31-34
- Section: Articles
- URL: https://journals.eco-vector.com/1728-2985/article/view/280569
- ID: 280569
Cite item
Abstract
The objective of the study was to compare the efficacy and safety of injections of botulinum toxin type A in the submucosal layer of the bladder and in detrusor in patients who were refractory to anticholinergic therapy of overactive bladder without detrusor overactivity. 100 U botulinum toxin type A was diluted in 10 ml of 0.9% saline and injected with 0.5 ml (5 units) of this solution in 20 points of the bladder (the back and side walls except Letto triangle). In twenty-two patients (the first group) botulinum toxin was injected into the submucosal layer of the bladder, while in 34 patients (second group) - into the detrusor. In the first group after 1 and 3 months 3 (14%) patients and after 6 months 2 (9%) patients had positive treatment outcomes (improvement of symptoms in more than 50%). In 22 (65%) of the 34 patients of the second group positive results were observed at 1 and 3 months and in 17 (50%) - at 6 months. After 9 months, all patients had a relapse of urgent and frequent urination. Difficulties in emptying the bladder were observed in three (9%) of the second group patients who had to resort to periodic self-catheterization for 2-20 weeks. The obtained results allow us to state that the injections of 100 U of botulinum toxin type A in the submucosal layer of the bladder are ineffective in patients with overactive bladder without detrusor overactivity, whereas injections in the detrusor lead to a statistically significant improvement in symptoms of urgent and frequent urination for 6 months.
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About the authors
G. G Krivoborodov
RNRMU n. a. N.I. Pirogov
Email: dr.krivoborodov@hotbox.ru
Department of Urology (Acting Head of Department
E. I Tur
RNRMU n. a. N.I. PirogovDepartment of Urology (Acting Head of Department
N. S Efremov
RNRMU n. a. N.I. PirogovDepartment of Urology (Acting Head of Department
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