Incidence of acute urinary retention in patients with prostatic adenoma and 8-year long tamsulosin therapy


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Abstract

This report introduces results of an 8-year study estimating the risk of acute urinary retention in patients with stage I prostatic adenoma. Patients were randomly assigned into two groups. The first group consisted of 331 men was regularly taking Omnic (tamsulosin) 0.4 mg 1 time daily for 8 years as a means of medical therapy. The second group consisted of 334 patients treated with herbal preparations (Gentos, Tadenan or Speman). In the case of acute urinary retention patients were taken to the urological department to release urine from the urinary bladder by catheterization or by the surgical procedure. The incidence of acute urinary retention in group 1 ranged from 0.3 to 1.2% per year and, for a total of 8 years of follow-up was 6.45%. In the second group, it ranged from 1.8 to 7.3% per year, making a total of 36.2%. Therefore, the risk of acute urinary retention in patients receiving Omnic (tamsulosin) was reduced by 5.6 times in comparison with the group of patients treated with herbal medications. Thus, the need for surgery decreased from 27.8 to 6.3%. According to the results of an 8-year long tamsulosin was found as a safe and highly effective means to reduce the risk of acute urinary retention.

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About the authors

M. I Davidov

SBEI HPE «Perm State Medical Academy n.a. ac. E.I. Vagner»

Email: midavidov@maiI.ru

K. L Lokshin

Research Institute of Uronephrology and Human Reproductive Health of Sechenov First Moscow State Medical University

I. S Gorbunova

SBEI HPE «Perm State Medical Academy n.a. ac. E.I. Vagner»

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