Nerve growth factor in the urine of patients with idiopathic detrusor overactivity and overactive bladder without detrusor overactivity
- Authors: Krivoborodov G.G1, Kolesanova E.F1, Tur E.I1, Efremov N.S1
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Affiliations:
- Russian National Research Medical University n.a. N.I. Pirogov
- Issue: No 3 (2015)
- Pages: 19-23
- Section: Articles
- URL: https://journals.eco-vector.com/1728-2985/article/view/281063
- ID: 281063
Cite item
Abstract
The purpose was to determine the concentration of the neurotrophin nerve growth factor in urine to assess its possible role as a marker in the diagnosis of various forms of overactive bladder. The study included patients with urinary frequency and urgency: 21 patients with idiopathic detrusor overactivity, 18 - with overactive bladder without detrusor overactivity and 11 healthy volunteers (control group). The level of nerve growth factor in the urine was determined in all participants of the study by the enzyme immunoassay (ELISA). In the control group the average ratio of nerve growth factor level to the level of urine creatinine was 0,2 ± 0,06, in patients with overactive bladder without detrusor overactivity - 0,33 ± 0,06 (p> 0.05). In patients with idiopathic detrusor overactivity the rate was significantly higher and amounted to 6,04 ± 0,9 (p <0.05). Therefore, measurement of the concentration of nerve growth factor in the urine may be used for differential diagnosis of the presence or absence of detrusor overactivity in patients with overactive bladder.
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About the authors
G. G Krivoborodov
Russian National Research Medical University n.a. N.I. Pirogov
Email: dr.krivoborodov@hotbox.ru
Department of Urology
E. F Kolesanova
Russian National Research Medical University n.a. N.I. PirogovDepartment of Urology
E. I Tur
Russian National Research Medical University n.a. N.I. PirogovDepartment of Urology
N. S Efremov
Russian National Research Medical University n.a. N.I. PirogovDepartment of Urology
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