Experimental Models of Stress Urinary Incontinence
- Authors: Makarov AV1, Fathudinov TH1, Tuhovskaja EA2, Apolihina IA1, Arutjunjan IV1, Ismailova AM2, Elchaninov AV1, Kananyhina EJ.1, Teterina TA1, Bolshakova GB3, Vasilev AV3, Glinkina VV4, Murashev AN2, Suhih GT1
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Affiliations:
- V.I. Kulakov Research Center for Obstetrics, Gynecology andPerinatology
- M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry
- Research Institute of Human Morphology
- Russian National Research Medical University n.a. N.I. Pirogov
- Issue: No 4 (2015)
- Pages: 24-28
- Section: Articles
- URL: https://journals.eco-vector.com/1728-2985/article/view/281604
- ID: 281604
Cite item
Abstract
To evaluate the safety and effectiveness of new methods at the preclinical stage, adequate and reproducible experimental models of SUI in laboratory animals should be used.
This article presents analysis of all SUI models described in the scientific literature and the results of an experimental study comparing two primary ways of modeling, based on bilateral pudendal nerve damage in female rats.
The experiment results showed that only bilateral electrocoagulation of proximal part of pudendal nerves by the posterior approach ensured a stable and long-term SUI symptoms in animals in the form of leak point pressure reduction in the urodynamic study and increase of the of the urethral lumen according to histomorphometric analysis.
The results suggest that an adequate experimental SUI model is urethral rabdomiosphincter denervation by pudendal nerve electrocoagulation by the posterior surgical approach, when the nerve is damaged in the area of its separation from sciatic nerve. In this case stable and reproducible results are obtainable.
About the authors
A V Makarov
V.I. Kulakov Research Center for Obstetrics, Gynecology andPerinatologyV.I. Kulakov Research Center for Obstetrics, Gynecology andPerinatology
T H Fathudinov
V.I. Kulakov Research Center for Obstetrics, Gynecology andPerinatologyV.I. Kulakov Research Center for Obstetrics, Gynecology andPerinatology
E A Tuhovskaja
M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic ChemistryM.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry
I A Apolihina
V.I. Kulakov Research Center for Obstetrics, Gynecology andPerinatologyV.I. Kulakov Research Center for Obstetrics, Gynecology andPerinatology
I V Arutjunjan
V.I. Kulakov Research Center for Obstetrics, Gynecology andPerinatologyV.I. Kulakov Research Center for Obstetrics, Gynecology andPerinatology
A M Ismailova
M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic ChemistryM.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry
A V Elchaninov
V.I. Kulakov Research Center for Obstetrics, Gynecology andPerinatologyV.I. Kulakov Research Center for Obstetrics, Gynecology andPerinatology
E Ju Kananyhina
V.I. Kulakov Research Center for Obstetrics, Gynecology andPerinatologyV.I. Kulakov Research Center for Obstetrics, Gynecology andPerinatology
T A Teterina
V.I. Kulakov Research Center for Obstetrics, Gynecology andPerinatologyV.I. Kulakov Research Center for Obstetrics, Gynecology andPerinatology
G B Bolshakova
Research Institute of Human MorphologyResearch Institute of Human Morphology
A V Vasilev
Research Institute of Human MorphologyResearch Institute of Human Morphology
V V Glinkina
Russian National Research Medical University n.a. N.I. PirogovRussian National Research Medical University n.a. N.I. Pirogov
A N Murashev
M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic ChemistryM.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry
G T Suhih
V.I. Kulakov Research Center for Obstetrics, Gynecology andPerinatologyV.I. Kulakov Research Center for Obstetrics, Gynecology andPerinatology
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