Nonbacterial Prostatitis Nonbacterial?


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The study involved 287 patients with chronic recurrent urethroprostatitis. In 83 (28.9%) of them the bacterial microflora in prostatic secretions was detected. The remaining 204 patients with nonbacterial prostatitis underwent in-depth laboratory testing. Cytological and immunological methods, electron microscopy, PCR, McCoy cell culture and developed by the authors the pre-culture pathogen accumulation technique were used to investigate urethral and prostatic smears. As a result C. trachomatis was detected in 84.8% of patients, T.vaginalis - 75.5%, and viruses of the Herpesviridae family - in 68.6%. Co-infection was diagnosed in 82.4% of patients, no infection was found in 6.9% of patients. The highest diagnostic sensitivity and specificity were observed in the pre-culture pathogen accumulation technique. According to electron microscopy, T. vaginalis was presented in several morphological shapes: flagellated, spherical and amoeboid. Thus, in 93.1% of patients who had previously been diagnosed with nonbacterial prostatitis by standard bacterial culture, the in-depth microbiological examination identified atypical infections (chlamydia, herpes virus, trichomonas), revealing that the rate of real nonbacterial (non-infectious) prostatitis did not exceed 6.9%.

About the authors

A V Strockij

Belarusian State Medical University

Belarusian State Medical University

A A Gavrusev

Belarusian State Medical University

Belarusian State Medical University

L V Rubanik

Republican Research and Practical Center for Epidemiology and Microbiology

Republican Research and Practical Center for Epidemiology and Microbiology

N N Poleshchuk

Republican Research and Practical Center for Epidemiology and Microbiology

Republican Research and Practical Center for Epidemiology and Microbiology

References

  1. Набер К.Г., Сухорукова М.В. Микробиологические аспекты диагностики хронического простатита. Клиническая микробиология и антимикробная химиотерапия. 2006;8(1):4-17.
  2. Collins M.M., Stafford R.S., O'Leary M.P., Barry M.J. How common is prostatitis? A national survey of physician visits. J. Urol. 1998;159:1224-1228. 3.
  3. The Urepik Study II, Comparative Prostatitis Data. <http://www>. prostatitis.org/population.html.
  4. Nickel J.C., Shoskes D.A., Wagenlehner F.M. Management of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS): the studies, the evidence, and the impact. World J. Urol. 2013;31:747-753.
  5. Строцкий А.В., Гаврусев А.А. Хронический уретропростатит: новые решения проблемы. ARS medica. 2012;5(60):9-11.
  6. Kiyota H., Onodera S., Ohishi Y., Tsukamoto T., Matsumoto T. Questionnaire survey of Japanese urologists concerning the diagnosis and treatment of chronic prostatitis and chronic pelvic pain syndrome. Int. J. Urol. 2003;10:636-642.
  7. Skerk V., Krhen I., Schonwald S., Cajic V., Markovinovic L., Roglic S., Zekan S, AndracevicA.T., Kruzic V. The role of unusual pathogens in prostatitis syndrome. Int. J. Antimicrob Agents. 2004;24:53-56.
  8. Kim T.H., Kim T.H., Kim H.R., Lee M.K., MyungS.-C., Sun-youngK. Detection of cryptic microorganisms in patients with chronic prostatitis by multiplex polymerase chain reaction. Korean J. Urol. 2007;48:304-309.
  9. Xiao J., Ren L., Lv H., Ding Q., Lou S., Zhang W., Dong Z. Atypical microorganisms in expressed prostatic secretion from patients with chronic prostatitis/chronic pelvic pain syndrome: microbiological results from a case-control study. Urol. Int. 2013;91:410-416.
  10. Badalyan R.R., Fanarjyan S.V., Aghajanyan I.G. Chlamydial and ureaplasmal infections in patients with nonbacterial chronic prostatitis. Andrologia. 2003;35:263-265.
  11. Stark J.R., Judson G., Alderete J.F., Mundodi V., Kucknoor A.S., Giovannucci E.L., Platz E.A., Sutcliffe S., Fall K., Kurth T., Ma J., Stampfer M.J., Mucci L.A. Prospective study of Trichomonas vaginalis infection and prostate cancer incidence and mortality: Physicians' Health Study. J. Natl. Cancer Inst. 2009;101:1-6.
  12. Toth M., Patton D.L., Campbell L.A., Carretta E.I., Mouradian J., Toth A., ShevchukM., Baergen R., Ledger W. Detection of chlamydial antigenic material in ovarian, prostatic, ectopic pregnancy and semen samples of culture-negative subjects. Am. J. Reprod. Immunol. 2000;43:218-222.
  13. Mazzoli S., Cai T., Addonisio P., Bechi A., Mondaini N., Bartoletti R. Chlamydia trachomatis infection is related to poor semen quality in young prostatitis patients. Eur. Urol. 2010;57:708-714. 14.
  14. European Association of Urology. Guidelines. 2014 edition. Guidelines on urological infections.
  15. Shurbaji M.S., Gupta P.K., Myers J. Immunohistochemical demonstration of Chlamydial antigens in association with prostatitis. Mod. Pathol. 1988;1:348-351.
  16. Heo C., Hong S.J., Gil M.C. Diagnostic Value of Polymerase Chain Reaction in Patients with Chronic Pelvic Pain Syndrome: using Semen as a Specimen. Korean J. Urol. 2007;48:189-194.
  17. Seo K.I., Hwang J.C., Kim T.W., Lee S.H., Park S.Y., Roh S.H. Results of Microorganism Detection by Multiplex Polymerase Chain Reaction in Patients with Chronic Pelvic Pain Syndrome. Korean J. Urol. 2009;50:1120-1124. 18.
  18. ChoI.C., Kim Y.S., Kim S.B., Kim S.K., Lee G.I., Min S.K. Prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, Ureaplasma urealyticum in Chronic Prostatitis Category IIIa and IIIb Patients Using Polymerase Chain Reaction. Korean J. Urogenit. Tract Infect. Inflamm. 2013;8:102-108.
  19. Skerk V., Schonwald S., Krhen I., Banaszak A., Begovac J., Strugar J., Strapac Z., Vrsalovic R., Vukovic J., Tomas M. Comparative analysis of azithromycin and ciprofloxacin in the treatment of chronic prostatitis caused by Chlamydia trachomatis. Int. J. Antim. Agents. 2003;21:457-462.
  20. Gardner W.A. Jr., Culberson D.E., BennettB.D. Trichomonas vaginalis in the prostate gland. Arch. Pathol. Lab. Med. 1986;110:430-432.
  21. Kaydos S.C., Hobbs M.M., Price M.A., Kazembe P., Hoffman I., Miller W.C., Cohen M.S. Sites of Trichomonas vaginalis infection in the genitourinary tract of Malawian men. Int. J. STD AIDS. 2001;12:38.
  22. Костюк С.А., Маркевич А.Л. Расширенная ПЦР-диагностика урогенитальных инфекций у пациентов андрологического профиля. Материалы V съезда дерматологов и венерологов Республики Беларусь. Минск: ДокторДиз, 2006. С. 204-206. 23.
  23. Advances in laboratory detection of Trichomonas vaginalis. Laboratory Detection of Trichomonas, 2013. Association of Public Health Laboratories. <http://www.aphl.org/AboutAPHL/> publications/Documents/ID_2013August_Advances-in- Laboratory-Detection-of-Trichomonas-vaginaUs.pdf.
  24. Овчинников H.M., Делекторский В. В. Ультраструктура возбудителей венерических заболеваний и ее клиническое значешге. М.: Медицина, 1986. 25.
  25. АЬонуі А. Examination of nonflagellate and flagellate round forms of Trichomonas vaginalis by transmission electron microscopy. Appl. Parasitol. 1995;3:303-310.
  26. Полещук H.H., Рубаник Л.В., Гаврусев A.A., Капитулец H.H., Костюк С.А. Ультраструктурные параметры метро- нидазолустойчивоспг Trichomonas vaginalis и трансформация простейших в различные морфоформы при длительном культивировании. Здравоохранение. 2010;5:29-33.
  27. Rasmussen S.E., Nielsen М.Н., Lind I. Morphological studies of the cytotoxiciti of Trichomonas vaginalis to normal human vaginal cells in vitro. Genitourinary Med. 1986;62:240-246.
  28. Гаврусев А.А. Диагностика и лечение хрошгческого уретропростангта. Дисс. канд. мед. наук. Минск, 2012. 24 с.
  29. Гаврусев А.А., Строцкий А.В. Современные тенденции в лечении хрошгческого абактериального простатита. Сборник тезисов X конгресса с международным участием «Мужское здоровье». Минск, 2014. С. 21-23.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies