Spermatogenesis recovery following allogeneic transplantation of undifferentiated Sertoli cells in experimental model of bilateral abdominal cryptorchidism
- Authors: Kulibin A.Y.1, Malolina E.A1,2, Jacyk S.P3, Zhamynchiev J.K3, Kuzin G.V4
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Affiliations:
- Koltzov Institute of Developmental Biology of RAS
- Gamaleya Scientific Research Institute of Epidemiology and Microbiology of Minzdrav of Russia
- Scientific Center of Children's Health
- Peoples’ Friendship University of Russia
- Issue: No 6 (2015)
- Pages: 74-81
- Section: Articles
- URL: https://journals.eco-vector.com/1728-2985/article/view/282312
- ID: 282312
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Abstract
This study explores the effect of transplantation of undifferentiated Sertoli cells in the testicular tissue of an experimental animal model of bilateral abdominal cryptorchidism. Effectiveness of undifferentiated Sertoli cell transplantation was assessed after 1 and 3 months after injection. Partial restoration of seminiferous tubules was found to occur after transplantation. In a third of them germ cells of all stages of the differentiation were discovered while they were not found in the control group.
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About the authors
A. Yu Kulibin
Koltzov Institute of Developmental Biology of RAS
E. A Malolina
Koltzov Institute of Developmental Biology of RAS; Gamaleya Scientific Research Institute of Epidemiology and Microbiology of Minzdrav of Russia
S. P Jacyk
Scientific Center of Children's Health
Je. K Zhamynchiev
Scientific Center of Children's Health
Email: Zhamynchiev@gmail.com
G. V Kuzin
Peoples’ Friendship University of RussiaFaculty of Medicine
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